Activate the skin's regenerative power!
Polynucleotide-containing injection for a youthful appearance
Rejuran (salmon injection)
Point1Injection containing polynucleotides (PN) extracted from salmon DNA
Point2Activates the skin's regenerative power, improving skin firmness and elasticity for a youthful appearance
Point3Also effective on acne scars, scars, fine lines around the eyes and dark circles where the skin is thin
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BIANCA CLINIC's unique initiatives
attempt
"Painless Rejuran" with an original formula that takes pain into consideration
At BIANCA CLINIC, we have independently researched the combination of drugs to reduce the stress caused by the pain of injections while maintaining the effectiveness of Rejuran. We offer "Painless Rejuran" which is a well-balanced combination of anesthetics. In addition, we use thin 34-gauge needles to reduce pain and internal bleeding, and we use 4mm and 2mm needles depending on the treatment to inject the drug more accurately into the targeted layer.
We understand the fear and anxiety that patients may feel when undergoing treatment that involves inserting needles directly into the skin, and we strive to provide painless treatment, making it as easy as possible for patients to undergo.
*Pain perception varies from person to person. Not all clients can receive treatment completely pain-free.
Case introduction
Cases
Cases.1
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Treatment name
rejuran i
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Our Treatments
Top: Before injection, Bottom: 1 weeks after one injection
Do you need forest bathing?
Recommended for:
I am concerned about fine lines around the eyes
thin skin around the eyes
I want firmness in my skin
I'm worried about dark circles under my eyes
I'm worried about acne scars
I want to treat open pores and dark spots.


Features
Characteristics
What is Rejuran (Salmon Injection)?
Rejuran (salmon injection) is a skin booster containing polynucleotides (PN) extracted from salmon DNA, which have the effect of repairing and regenerating cells and tissues and promoting new blood vessels.
By stimulating fibroblasts and causing cell proliferation to regenerate the skin, it thickens the epidermis and dermis, improving skin firmness, tightening, and increasing elasticity and volume. It also increases vascular endothelial growth factor (VEGF) and promotes blood vessel formation, improving local blood flow and helping to improve dark circles around the eyes caused by congestion. It has an anti-inflammatory effect, helping to repair acne scars and scars and reduce UV damage. It balances sebum and improves the skin's moisturizing power, improving the skin's texture, and other functions to give the skin a youthful appearance.
Use Rejuran and Rejuran i according to your concerns
At BIANCA CLINIC, we use both regular Rejuran and Rejuran i (Rejuran Eye), which is suitable for eye treatments, depending on the patient's concerns, treatment area, and skin condition.
Regular Rejuran is primarily used on the entire face, forehead, neck and décolleté, and is unique in that it is versatile and can be used to treat a wide range of concerns, including improving sagging, firmness, enlarged pores, nasolabial folds, wrinkles on the forehead and acne scars.
Rejuran i is a specialized formulation for the eye area that has low viscosity and is easily absorbed, making it suitable for treating fine lines and dark circles under the eyes, where the skin is thin. It can also be used around the mouth, where the skin is delicate.

Natural rejuvenation without the feeling of having done anything
Rejuran (Salmon Injection) helps produce a variety of growth factors in skin tissue, creating a favorable environment for cell proliferation. By enhancing the skin's natural healing ability and fundamentally repairing skin damaged by aging and dryness, this treatment is expected to achieve natural rejuvenation that goes beyond simply increasing volume.
Unlike hyaluronic acid injections, which do not produce dramatic results such as lifting wrinkles or adjusting the volume of certain parts of the body in a single injection, it does not restore elasticity and firmness to the skin, making it possible to address wrinkles and fine lines that are difficult to improve with hyaluronic acid or Botox injections, resulting in a natural finish without any feeling of having been done.






Benefit
Merit
Merit.1
It is easily absorbed into the skin and has an effect deep within the skin.
Salmon-derived polynucleotides are compatible with humans, and because they are small molecules they are easily absorbed into the skin. The skin stabilizes immediately after administration, and the effects can be felt deep within the skin.
Merit.2
Enhances natural healing ability, so the effects are less likely to reverse
This treatment enhances the skin's natural healing ability and promotes repair and regeneration from the root, so the results are unlikely to be reversed.
Merit.3
Treatment can be done with a formulation specialized for the eye area
The skin around the eyes is thin and can be a cause for concern. Rejuran i is a soft, easy-to-absorb formulation specially designed for use around the eyes.
Treatment site
Treatment Area
Forehead, temples, tear bags, above eyes, tip of nose, bridge of nose, golgo line, nasolabial fold, lips, chin, face line, back of hands, etc.
Price list
Price list
Advice from Doctor BIANCA
Advice
■Combined injection of Rejuran i and Botox for clear, radiant skin
At BIANCA CLINIC, we not only treat with Rejuran i alone, but also inject it in combination with Botox. Rejuran i's effect of restoring the skin's moisturizing power and elasticity and making wrinkles less noticeable, and Botox's effect of reducing pores and suppressing sebum, work together to create a synergistic effect that aims to give you clear, lustrous skin. If you are interested in a treatment that combines the best of both Rejuran i and Botox, such as wanting Korean skin or wanting to pursue firmer skin, please feel free to contact us.
■A total of four injections are recommended, spaced 2-3 weeks apart.
This is a treatment that allows you to feel a change in your skin texture after just one treatment. Although results may vary from person to person, we recommend a total of four treatments, scheduled every two to three weeks in accordance with the skin's regeneration cycle, to ensure you see a more definite change. After that, you can expect the effects to last if you receive maintenance treatments roughly once every six months.
■Progression after Rejuran treatment
Immediately after Rejuran treatment, the injection site will be slightly raised like a mosquito bite, and the skin will be bumpy, but this will subside within a few hours to a day. The treatment site may also swell, and internal bleeding may occur at the site where the needle was inserted. Although this varies from person to person, it will take a few days for the swelling to subside, and about a week if internal bleeding occurs. Avoid treatment just before an important event, and make your reservation with about 1 days to spare.
Makeup is possible from the day after the procedure, so if you are concerned about swelling or internal bleeding immediately after the procedure, we recommend that you bring sunglasses and a mask. Please refrain from washing your face for 6 hours after the procedure, and only showers are allowed on the day of the procedure. Bathing is permitted from one week after the procedure.
Flow of treatment
Content of treatment
01 Doctor's examination/counseling
The details of the Rejuran (Salmon Injection) treatment will be explained in detail during counseling, and the doctor will check the condition of your skin during an examination and determine the injection site. Please let us know your wishes, as well as any worries, questions, or concerns you may have. We will take the time to carefully examine you.

02 Injection site make-off
Before the Rejuran treatment, please remove your makeup and wash your face. Cleansing products and facial cleansers are provided at our clinic.
03 麻 酔
A topical anesthetic is administered to reduce the pain caused by the needle insertion. At our clinic, the Rejuran medication also contains an anesthetic, aiming for treatment that is painless.
04 Treatment
After some time has passed and the epidermal anesthesia has taken effect, the treatment begins. The medicine is injected in small amounts by hand. The treatment takes approximately 15 to 30 minutes, and the treatment is finished once pressure has been applied to stop the bleeding.

we also focus on minimizing downtime for treatments.
Downtime
Frequently Asked Questions Q&A・Notes
Q&A
Treatment time: 15 to 30 minutes
Estimated number of treatments: Approximately 2 times every 3 to 4 weeks. After that, maintenance is recommended approximately once every 1 months.
Bathing and washing your face: Showers and washing your face are possible from the day of treatment, but please avoid bathing on the day of treatment.
Make-up: Possible from the next day
Contraindications: The following people cannot receive treatment:
・Pregnant, breastfeeding, or those who may be pregnant
-People using NSAIDs, immunosuppressants, coagulation inhibitors, or anticoagulants
・Those with chronic illnesses such as autoimmune diseases or sarcoidosis
・People with allergies to fish, fish eggs, etc.
-People who are hypersensitive to the product's components (sodium polynucleotide)
-Those who are planning to undergo or have recently undergone treatment with non-resorbable fillers
-Those with inflammation, infection, or other conditions that a doctor has determined are unsuitable for treatment
*Please ask your doctor for details.
Precautions:
- Pain, itching, and inflammation (redness, edema, erythema) at the injection site may persist for about a week.
・If internal bleeding or swelling occurs at the injection site, it will disappear within 1 to 2 weeks.
- Avoid prolonged exposure to UV rays for 1 to 2 weeks after injection.
Side effects/risks: pain, redness, swelling, internal bleeding, allergic reaction
Regarding the formulation:
・Rejuran and Rejuran i include treatments using medicines or medical devices that are not approved in Japan.
- The medicines and medical equipment used in treatment have been imported by individuals at the discretion of our doctors.
・There are no other drugs approved in Japan that have the same ingredients and properties.
・Serious side effects may not have been identified.
・Please refer to the following for information regarding medicines etc. that you should be careful about when importing for personal use.
https://www.yakubutsu.mhlw.go.jp/individualimport/purchase/index.html
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