An approach using autologous cells! An advanced treatment that is attracting attention from around the world
Next-generation anti-aging care that regenerates skin from the roots
Nanostem
Point1Born from the fusion of two technologies! BIANCA's unique advanced skin quality improvement treatment
Point2Approaching multiple skin problems! Expect natural, smooth improvement to skin quality
Point3Using autologous cells reduces risk! Downtime is short and there is little disruption to daily life.
Nanostem
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BIANCA CLINIC's unique initiatives
attempt
The first in Japan to introduce NanoStem!
Bianca's new approach to skin regeneration
Bianca Clinic is one of the first to adopt NanoStem, which has yet to be introduced in many cases in Japan! This treatment, which applies knowledge from regenerative medicine, is suitable for those who are looking for anti-aging care that targets the skin quality itself.
NanoStem, which combines Silky Fat and Dermapen 4, does not use conventional fat injections to fill in the volume, but instead focuses on skin regeneration. This gives a natural finish and long-lasting effects. You can experience the sensation of "nurturing" the changes in your skin.
This treatment is Bianca's "new skin regeneration option" and is suitable for those looking for essential anti-aging care that addresses age-related skin problems from the root.
Case introduction
Cases
Cases.1
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Treatment name
Nanostem
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Our Treatments
Left photo: Before treatment / Right photo: 10 days after treatment
◆ Treatment period and number of sessions: 1 session
◆Cost: ¥242,000, NanoStem 1 session ¥110,000
◆Risks and side effects: swelling, internal bleeding, pain, redness, dryness, stinging, hardening, unevenness, allergic reactions, etc.
Do you need forest bathing?
Recommended for:
I want to restore firmness and radiance to my skin
I want to take care of my aging skin.
I want to improve my acne scars and pore problems.
I want to treat wrinkles, fine lines, and dents in my skin.
I want to improve the appearance of pores
I am concerned about dry and dull skin
Want to promote skin turnover
Looking for a natural rejuvenating effect?


Features
Characteristics
What is NanoStem?
NanoStem is an anti-aging treatment that uses silky fat extracted from the patient's own fat and specially processed to introduce it into the skin using Dermapen 4. First, the fat collected from the patient is centrifuged to remove unnecessary components and refine it into condensed rich fat (CRF). Bianca's unique strength is that it uses silky fat obtained by further micronizing and refining CRF.
Silky Fat is characterized by its finer fat size than conventional nanofat, which is made by processing CRF fat into smaller size. It is rich in stem cells, exosomes, and growth factors, and aims to improve skin quality by supporting the skin's natural healing and regenerative abilities.
By delivering this silky fat to the very shallow layers of the skin using the Dermapen 4 microneedle device, which is equipped with extremely fine needles, it brings out the skin's regenerative power at the cellular level.
Dermapen 4 uses 16 needles to make tiny holes in the skin, inducing wound healing while uniformly delivering drugs and ingredients. In combination with Silky Fat, it promotes restructuring from deep within the skin, helping to restore firmness and elasticity that tend to be lost with age.
Bianca Clinic was one of the first to introduce cutting-edge beauty treatments that utilize the skin's regenerative powers. These treatments are chosen by those who value a natural finish and those who want to address their skin problems from the root.

Approach the skin with ultra-fine needles! Efficiently introduce CRF into the superficial dermis layer
NanoStem uses the microneedles of the Dermapen 4 to create tiny holes (channels) in the skin. Silky Fat penetrates deep into the skin (superficial dermis) through these channels. Silky Fat is rich in CRF-derived stem cells, exosomes, and growth factors, which work to stimulate the skin's ability to repair and regenerate.
The needles used in the procedure are very thin, so they put less strain on the skin, and the results are more natural than with traditional fat injections. It can be used on the entire face, including the forehead, cheeks, and chin, as well as delicate areas such as the eyes and mouth.
In addition, the Dermapen itself has the effect of promoting wound healing, which supports collagen production and is expected to improve overall skin quality.

Awakens skin firmness and radiance from within! Natural and lasting skin-beautifying effects
The fat-derived stem cells contained in Silky Fat are also known as stem cell fat injections, and are attracting attention as an ingredient that supports the skin's natural regenerative power. The growth factors and cytokines secreted from the cells are suggested to be involved in the activation of fibroblasts, promoting the production of collagen and elastin. This is said to gradually restore the firmness and luster of the skin.
The effect of NanoStem is that many people feel a change in the texture of their skin over a period of several weeks to several months. Therefore, the advantage is that it is difficult for others to notice and it is easy to feel a natural rejuvenation.
For those who want to tackle age-related skin problems from the root, NanoStem will be a new anti-aging care that gives you the feeling that your skin is "growing" from the inside out.







Benefit
Merit
Merit.1
Regenerative power that improves skin firmness and elasticity from the roots
The stem cells contained in Silky Fat stimulate the production of collagen and elastin, plumping the skin from within and gently improving elasticity and radiance.
Merit.2
Addresses multiple skin concerns such as pores, fine lines, acne scars, and dullness
By promoting skin reconstruction, it can simultaneously address a variety of skin problems such as enlarged pores, fine lines, acne scars, and dullness.
Merit.3
Because it is derived from autologous tissue, minimally invasive treatment with minimal damage to the skin is possible.
Because the patient's own fat is used, there is little risk of rejection and minimal irritation to the skin. This treatment is designed with safety and a natural finish in mind.
Treatment site
Treatment Area
Face, neck, décolleté, buttocks, back of hands
Price list
Price list
Advice from Doctor BIANCA
Advice
■Can be applied to areas of concern such as the face, neck, and décolleté
NanoStem can be used not only on the face, but also on areas that are prone to showing signs of aging, such as the neck, décolleté, buttocks, and back of the hands. The treatment area and amount of fat taken can be adjusted according to your concerns, allowing for customized treatment aimed at improving skin quality all over the body.
At Bianca, we propose the best treatment plan for each patient, so please feel free to consult us if you have any concerns.
■Feel the effects slowly! Natural back-aging with long-term skin development
The effects of NanoStem do not appear within a few days of treatment, but rather appear gradually for many people. Collagen and elastin production progresses over the course of several months, and the texture of the skin gradually becomes smoother.
Although it varies from person to person, the effect peaks after 3 to 6 months. Therefore, the appeal is that people around you will naturally notice the change and ask, "Has your skin gotten prettier recently?" This is the ideal anti-aging care for those who want to cultivate beauty in the long term, rather than just short-term changes.
■Combining it with other treatments is also effective! For even more beautiful skin
NanoStem can be used in combination with other cosmetic treatments to achieve a synergistic effect on skin beauty. It is especially recommended to combine it with PRP therapy, lasers, and high-concentration vitamin C drips to support recovery.
Combining NanoStem, which promotes skin regeneration, with treatments that promote blood circulation and have antioxidant properties allows for more comprehensive care, such as tightening the skin, evening out skin tone, and improving skin clarity. This combination treatment offers greater possibilities for customized treatments for those who wish to treat multiple concerns at the same time. If you're looking to resolve all your concerns at once, please feel free to consult Bianca.
Flow of treatment
Content of treatment
01 Doctor's examination/counseling
We will carefully check your skin condition and concerns to determine whether NanoStem is suitable for you. From a dermatological perspective, we will carefully plan the treatment area, insertion depth, fat extraction area, etc.

02 Liposuction
The required amount of fat is harvested from the stomach or thighs. Anesthesia can be selected from intravenous anesthesia or relaxing anesthesia, and liposuction is performed while the patient is asleep, so there is little pain or tension during the procedure. Although surgical techniques are used, we minimize the burden on the patient and proceed with consideration for safety.

03 Treatment
The collected fat is processed into silky fat that is rich in stem cells and growth factors. It is then evenly introduced into the superficial dermis layer of the skin using Dermapen 4. This approach utilizes the regenerative power of stem cells to promote the reconstruction of the skin itself.
NanoStem is a comprehensive treatment process unique to Bianca that combines the three fields of dermatology, surgery, and regenerative medicine. NanoStem, which utilizes the expertise of each field, is a step ahead in anti-aging care that we provide with confidence.

we also focus on minimizing downtime for treatments.
Downtime
After surgery, your skin may become dry, so be sure to moisturize it thoroughly and avoid exposure to the sun.
Frequently Asked Questions Q&A・Notes
Q&A
[Treatment details] Silky fat collected from the abdomen or thighs is introduced into the skin using a dermapen.
[Estimated treatment period and frequency] 1 session *Depends on the condition.
[Cost] Fat extraction processing fee: ¥242,000, NanoStem 1 session: ¥110,000-¥220,000 *Depends on the area.
[Risks/Side Effects, etc.] Swelling, internal bleeding, pain, redness, dryness, stinging, hardening, unevenness, allergic reactions, etc.
[Caution regarding unapproved devices and medicines]
・This treatment includes medicines that are not approved in Japan or treatments that have a different purpose than that approved by the Ministry of Health, Labor and Welfare.
・Medicines and medical equipment used in treatment are introduced at the discretion of our clinic's doctors.
-Serious risks or side effects may not be known.
・In the unlikely event that serious side effects occur, you will not be covered by the national pharmaceutical adverse reaction relief system.
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