column (e.g. in newspaper)
2025.07.27
The Elixir of Immortality!? What are NMN and NAD+?
A dual-specialty doctor with a background in plastic surgery, bridging cosmetic surgery and ophthalmology. At the university hospital, he performed numerous high-difficulty cases, primarily focusing on eye and facial bone surgeries, cultivating precise techniques grounded in anatomy. He prioritizes achieving both aesthetic beauty and functional safety, offering customized treatments around the eyes that incorporate ophthalmological expertise. He actively utilizes not only incisional surgery but also non-invasive procedures like hyaluronic acid injections. By carefully assessing each individual's condition and unique appeal, he provides bespoke treatments that guide patients toward naturally harmonious, well-defined eyes.
Hello,Plastic Surgeon Shaping Impressions: Ryutaro Natsumeis
What exactly are these ”NMN” and ”NAD+” I keep hearing about lately?
We've got the answers to your questions!
The First Emperor who sought the elixir of immortality. Cleopatra, the ancient Egyptian queen who yearned for eternal youth.
Immortality and longevity have long been a dream of humankind. In recent years, significant progress has been made in research and treatment.
⸻
What are the "youth-restoring genes," the sirtuin genes?
The sirtuin gene, discovered around 2000, is known as the "rejuvenation gene."
It is known that humans possess seven types of sirtuin genes, designated SIRT1 through SIRT7.
SIRT1 in particular is believed to have cancer-suppressing effects, control over stress/inflammation/immune responses, and promote antioxidant activity.
In studies of mice with enhanced SIRT1 function, 16.4% of females and 9.1% of malesHealthy life expectancy has increasedIt has also been reported.
⸻
What is NAD+, which activates the sirtuin gene?
Living organisms require ATP for energy to function, and it is produced in structures called mitochondria.
a substance found within living organismsNAD+It is an essential coenzyme for producing ATP and also activates the sirtuin genes.
It is said that NAD+ levels decrease to about half of those in one's 20s by one's 50s, and this reduction in intracellular concentration is thought to accelerate aging.
In other wordsMaintaining NAD+ levels is the secret to youthfulness. is.
There are mainly two methods.
・NMN Oral/IV Drip
NMN, considered a precursor to NAD+, is one of the components found within vitamin B3. Its formal name is "nicotinamide mononucleotide."
NMN is converted into NAD+ within the body.
NMN is also found in foods, particularly in edamame, broccoli, and cucumbers. However, to consume 100mg of NMN per day from broccoli alone, you would need approximately 40kg (about 2000 florets).
Therefore, oral administration or intravenous therapy of NMN itself is recommended.
Intravenous administration is absorbed faster, so we recommend IV for those who want to feel the effects quickly, and oral medication for those who want to maintain the effects over time.
・NAD+ IV Drip
Until now, it was thought that directly introducing NAD+ into living organisms was difficult and that it needed to be introduced via its precursor, NMN.
Recently, a pathway for directly introducing NAD+ into the body has been discovered, and NAD+ IV drips have also begun.
⸻
NMN oral/IV vs. NAD+ IV—which is better? What are the noticeable effects?
Fatigue recovery, skin rejuvenation, mental clarity, improved sleep qualityThe following effects can be expected.
Both oral NMN and NAD+ IV therapy are safe and effective methods for compensating for NAD+ depletion. Future research is expected to further clarify which approach is more efficient and effective.
⸻
What is the recommended starting age?
Individuals in their teens and twenties maintain sufficiently high intracellular NAD+ concentrations, making it difficult to perceive noticeable effects from its use.
We recommend starting treatment for anti-aging in your 30s, when NAD+ levels begin to decline!
⸻
Summary
To activate the rejuvenation gene SIRT1, oral NMN/intravenous NMN and NAD+ intravenous therapy are effective.
We recommend starting treatment after age 30, when NAD+ levels begin to decline.
We only get one life—let's extend our healthy lifespan and live vibrantly and joyfully.
⸻
Reservations can be made here.
Complete your reservation in 60 seconds ▶︎
https://reservation.medical-force.com/b/d7bb811e-ebd5-4b93-93f8-588864b24f15
⸻
※There are various approaches to aesthetic medicine, and opinions and practices may differ among physicians. Please consider the information provided here as one reference only, and we hope you will choose medical care that suits you and meets your expectations.
We apologize if any unintended inaccuracies or misleading expressions were included. In such cases, we will make appropriate corrections or additions.
【Profile】
Plastic Surgeon Dr. Ryutaro Natsume
https://biancaclinic.jp/doctor/natsume/
Performed numerous facial surgeries, particularly focusing on the eye area and facial bones, in the field of plastic surgery.
Regarding treatments for the eye area, I believe that not only aesthetic appearance but also ophthalmic functionality is extremely important. To provide safer and more reliable treatments, I am currently deepening my expertise as an ophthalmologist.
We actively incorporate non-surgical procedures such as hyaluronic acid injections, in addition to treatments requiring surgical instruments.
From a multifaceted professional perspective encompassing cosmetic surgery, cosmetic dermatology, reconstructive surgery, and ophthalmology
BIANCA CLINIC, a leading Japanese clinic specializing in beauty and regenerative medicine, provides the latest aesthetic treatments.
【Career】
2020: Graduated from Tokyo Medical University Tokyo Metropolitan Saiseikai Central Hospital
2022 Jikei University Hospital Department of Plastic Surgery
2023 Department of Plastic Surgery Jikei University School of Medicine Kashiwa Hospital
2024 BIANCA CLINIC
【Professional Affiliations/Qualifications】
Japanese Society of Aesthetic Surgery (JSAS)
Full Member of the Japan Society of Plastic and Reconstructive Surgery
Full Member of the Japanese Society of Craniofacial Surgery
Full Member of the Japanese Ophthalmological Society
【SNS】
Instagram account
https://www.instagram.com/dr.natsume?igsh=OHBvd3VtajV1bmY1&utm_source=qr
RESERVATION