column (e.g. in newspaper)
2025.09.04
NEAUVIA STIMULATE vs HArmonyCa: What is a Calcium Hydroxyapatite Preparation?
A dual-specialty doctor with a background in plastic surgery, bridging cosmetic surgery and ophthalmology. At the university hospital, he performed numerous high-difficulty cases, primarily focusing on eye and facial bone surgeries, cultivating precise techniques grounded in anatomy. He prioritizes achieving both aesthetic beauty and functional safety, offering customized treatments around the eyes that incorporate ophthalmological expertise. He actively utilizes not only incisional surgery but also non-invasive procedures like hyaluronic acid injections. By carefully assessing each individual's condition and unique appeal, he provides bespoke treatments that guide patients toward naturally harmonious, well-defined eyes.
Hello, I'm Ryutaro Natsume, an image designer and cosmetic surgeon.

Many people become concerned about sagging caused by bone and soft tissue atrophy with age, as well as a loss of firmness due to decreased collagen in the dermis.
This time, we introduce a hydroxyapatite formulation that can improve both!
Hydroxyapatite (CaHA) is a type of calcium phosphate found in human teeth and bones.
When injected subcutaneously, it provides long-lasting collagen-boosting effects, increasing dermal volume and enhancing firmness.
A dual-effect hybrid injection formulation combined with hyaluronic acid is now available!
・Hyaluronic acid provides instant volume enhancement and lifting effects
・Gradual and long-term collagen production promotion effect by calcium hydroxyapatite
can be expected.
It delivers effects that conventional hyaluronic acid formulations could not achieve.
◯NEAUVIA STIMULATE
CaHA concentration is low (1%)
NEAUVIA series has reported zero cases of allergies (because it does not use BDDE, the substance responsible for hyaluronic acid allergies).
Use this when you want to achieve substantial volume while also expecting some collagen production.
◯Harmonica (HArmonyCa) Allergan


High CaHA concentration (55%)
Recommended for those in their late 30s experiencing collagen loss and with relatively thin skin.
It effectively improves volume while promoting collagen production to enhance skin firmness.
It is recommended for anti-aging purposes.
Summary of Usage Differences
◯NEAUVIA STIMULATE→
20s to 30s
I want to add substantial volume and shape the contours, while also achieving a bit more firmness.
◯Harmonica (HArmonyCa) Allergan
In my late 30s, with relatively thin skin
Primarily focuses on skin-nourishing effects, with a slightly subdued volume for a natural finish.
Clinics offering hydroxyapatite (CaHA) treatments are still relatively rare in Japan.
Please feel free to consult with our clinic, which has extensive treatment experience!
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Reservations can be made here.
Complete your reservation in 60 seconds ▶︎
https://reservation.medical-force.com/b/d7bb811e-ebd5-4b93-93f8-588864b24f15
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※There are various approaches to aesthetic medicine, and opinions and practices may differ among physicians. Please consider the information provided here as one reference only, and we hope you will choose medical care that suits you and meets your expectations.
We apologize if any unintended inaccuracies or misleading expressions were included. In such cases, we will make appropriate corrections or additions.
【Profile】
Plastic Surgeon Dr. Ryutaro Natsume
https://biancaclinic.jp/doctor/natsume/
Performed numerous facial surgeries, particularly focusing on the eye area and facial bones, in the field of plastic surgery.
Regarding treatments for the eye area, I believe that not only aesthetic appearance but also ophthalmic functionality is extremely important. To provide safer and more reliable treatments, I am currently deepening my expertise as an ophthalmologist.
We actively incorporate non-surgical procedures such as hyaluronic acid injections, in addition to treatments requiring surgical instruments.
From a multifaceted professional perspective encompassing cosmetic surgery, cosmetic dermatology, reconstructive surgery, and ophthalmology
BIANCA CLINIC, a leading Japanese clinic specializing in beauty and regenerative medicine, provides the latest aesthetic treatments.
【Career】
2020: Graduated from Tokyo Medical University Tokyo Metropolitan Saiseikai Central Hospital
2022 Jikei University Hospital Department of Plastic Surgery
2023 Department of Plastic Surgery Jikei University School of Medicine Kashiwa Hospital
2024 BIANCA CLINIC
【Professional Affiliations/Qualifications】
Japanese Society of Aesthetic Surgery (JSAS)
Full Member of the Japan Society of Plastic and Reconstructive Surgery
Full Member of the Japanese Society of Craniofacial Surgery
Full Member of the Japanese Ophthalmological Society
Full Member of the Japanese Society of Aesthetic Medicine
【SNS】
Instagram account
https://www.instagram.com/dr.natsume?igsh=OHBvd3VtajV1bmY1&utm_source=qr