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2025.09.22
Botox stops working... What are neutralizing antibodies? ”Coatox” is recommended.
A dual-specialty doctor with a background in plastic surgery, bridging cosmetic surgery and ophthalmology. At the university hospital, he performed numerous high-difficulty cases, primarily focusing on eye and facial bone surgeries, cultivating precise techniques grounded in anatomy. He prioritizes achieving both aesthetic beauty and functional safety, offering customized treatments around the eyes that incorporate ophthalmological expertise. He actively utilizes not only incisional surgery but also non-invasive procedures like hyaluronic acid injections. By carefully assessing each individual's condition and unique appeal, he provides bespoke treatments that guide patients toward naturally harmonious, well-defined eyes.
Hello, I'm Ryutaro Natsume, an image designer and cosmetic surgeon.
Reducing excessive facial muscle movement with Botox creates a refined appearance and effectively prevents wrinkles and sagging.
However, with long-term use of Botox, the duration of effect may gradually decrease, and the dosage may need to be increased.
This is because neutralizing antibodies reduce the effectiveness of Botox. However, it does not appear to render it completely ineffective.
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”To avoid producing neutralizing antibodies
◯ Leave a 3-month gap between administration periods
Do not administer additional small doses or inject into other areas within the same period. When getting Botox, do all the injections at once.
◯ Use ”Core Tox”
The cause of neutralizing antibody production is thought to be the complex protein contained in Botox.
A representative formulation that does not contain complex proteins is ”Coatox.”
The duration and efficacy are unchanged from existing formulations.
High total dosage users, those requiring repeated treatments every 3-6 months, and individuals experiencing reduced Botox effectiveness will also find this highly recommended!
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The effect is diminished when done immediately after Botox
◯ Avoid long baths and saunas(At least 3 days, preferably 1 week)
Since botulinum bacteria are inactivated by heat, refrain from using it until the effects appear.
◯Refrain from massage(At least 3 days, preferably around 1 week)
Refrain from using it, as it may penetrate other areas and cause unexpected effects.
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Summary
This time, we explained ”neutralizing antibodies,” which reduce the effectiveness of Botox.
Using ”Coatox,” which does not contain the causative complex protein, can reduce the risk of neutralizing antibodies developing.
This is especially recommended for those requiring higher total doses, those undergoing repeated treatments every 3-6 months, and those for whom Botox has already become less effective.
Regarding Botox, the blog is also
Botox Without Fail: Common Mistakes Explained
Do you really need that jawline filler? Beware of sunken cheeks and sagging skin⚠️
Please be sure to read this as well.
Feel free to ask about Botox injections.
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Reservations can be made here.
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https://reservation.medical-force.com/b/d7bb811e-ebd5-4b93-93f8-588864b24f15
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※There are various approaches to aesthetic medicine, and opinions and practices may differ among physicians. Please consider the information provided here as one reference only, and we hope you will choose medical care that suits you and meets your expectations.
We apologize if any unintended inaccuracies or misleading expressions were included. In such cases, we will make appropriate corrections or additions.
【Profile】
Plastic Surgeon Dr. Ryutaro Natsume
https://biancaclinic.jp/doctor/natsume/
Performed numerous facial surgeries, particularly focusing on the eye area and facial bones, in the field of plastic surgery.
Regarding treatments for the eye area, I believe that not only aesthetic appearance but also ophthalmic functionality is extremely important. To provide safer and more reliable treatments, I am currently deepening my expertise as an ophthalmologist.
We actively incorporate non-surgical procedures such as hyaluronic acid injections, in addition to treatments requiring surgical instruments.
From a multifaceted professional perspective encompassing cosmetic surgery, cosmetic dermatology, reconstructive surgery, and ophthalmology
BIANCA CLINIC, a leading Japanese clinic specializing in beauty and regenerative medicine, provides the latest aesthetic treatments.
【Career】
2020: Graduated from Tokyo Medical University Tokyo Metropolitan Saiseikai Central Hospital
2022 Jikei University Hospital Department of Plastic Surgery
2023 Department of Plastic Surgery Jikei University School of Medicine Kashiwa Hospital
2024 BIANCA CLINIC
【Professional Affiliations/Qualifications】
Japanese Society of Aesthetic Surgery (JSAS)
Full Member of the Japan Society of Plastic and Reconstructive Surgery
Full Member of the Japanese Society of Craniofacial Surgery
Full Member of the Japanese Ophthalmological Society
Full Member of the Japanese Society of Aesthetic Medicine
【SNS】
Instagram account
https://www.instagram.com/dr.natsume?igsh=OHBvd3VtajV1bmY1&utm_source=qr
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