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2024.09.16
What is GLP-1 Dieting? Explaining the Differences Between Saxenda, Ugoobi, and Manjaro
With deep medical insight cultivated as an internal medicine specialist, I bridge aesthetic surgery, dermatology, and internal medicine. Having spent my childhood in China, I communicate fluently in Japanese, Chinese, English, and Korean. Possessing an international perspective—evidenced by invitations to present at overseas conferences—I actively promote techniques as a Key Opinion Leader (KOL) for GOURI and REJURAN®. My specialty procedures include double eyelid surgery, skin-nurturing boosters, and body hyaluronic acid treatments. My approach leverages the holistic understanding of the body cultivated through internal medicine to guide patients toward natural, healthy beauty.

Dr. Senki Akashi of BIANCA CLINIC explains the much-talked-about "GLP-1 Diet."
We have summarized the differences between the three formulations and their usage precautions.
If you're interested in GLP-1 diets, please read on.
What is GLP-1 Dieting?

GLP-1 Diet is,Medical weight loss that suppresses appetite through medication while aiming for sustainable weight managementis.
Have you heard that you can lose weight without strict dieting or intense exercise? If so, you might be interested in GLP-1 diet therapy.
At first glance, it seems like something you could easily start, butImproper use may carry risks, so it must be performed under professional supervision.。
GLP-1 receptor agonists are approved as diabetes medications; however, their use for cosmetic or weight loss purposes constitutes off-label use (as of June 2025, in Japan).
Therefore, it is important to fully understand the risks and side effects when using it and proceed in consultation with your doctor.
Seeking quick results by using personal imports or other products without professional guidance is extremely dangerous. Avoid this practice at all costs.
GLP-1 Diet|Comparing Three Medications

While referred to as GLP-1 diets, the medications themselves actually vary.
Let me explain the differences between each medication.
Saxenda: Once-daily self-injection for appetite suppression
A self-injectable medication marketed by Novartis Pharma. The active ingredient is "liraglutide."
Administered once daily, it controls blood sugar levels and suppresses appetite.
Bianca Clinic also carries it.▼
https://biancaclinic.jp/treatment_category/body/diet_01/glp-1-saxenda/
Ugobi: Easy to maintain with just one injection per week
Semaglutide is a formulation containing the active ingredient semaglutide, administered as a weekly injection.
While approved in some countries overseas as an obesity treatment drug, it remains unapproved in Japan (for weight loss purposes).
Mangaro (Zepbound): A formulation with a novel mechanism of action
The active ingredient “tirzepatide” is a dual agonist that acts on both GLP-1 and GIP receptors.
While it is said to be prone to weight fluctuations, both its effects and side effects vary significantly from person to person, making medical supervision essential.
Bianca Clinic also carries it.▼
https://biancaclinic.jp/treatment/body/diet_01/mounjaro/
Side Effects and Risks of GLP-1 Receptor Agonists
GLP-1 agents have been reported to cause side effects such as nausea, constipation, diarrhea, hypoglycemia, and pancreatitis.
Not everyone will experience this, but if you notice any unusual symptoms, please consult a doctor immediately.
Furthermore, these drugsNot covered by the Adverse Drug Reaction Relief Systemis.
Please undergo treatment only after fully understanding that it is private medical care and that it is not approved.
[Summary] GLP-1 Diet Requires Proper Medical Supervision
GLP-1 drugs used for "GLP-1 diet" are all pharmaceuticals not approved in Japan for weight loss purposes.
The effects on the body vary from person to person, and the risk of side effects is not zero.
To proceed safely with treatment, it is essential to avoid self-diagnosis and instead work continuously with a trusted physician to monitor your progress.
Bianca Clinic employs internal medicine specialists, including Dr. Yoko Maeda, a director of the Japanese Society of Aesthetic Internal Medicine.
We provide comprehensive care from counseling through post-treatment follow-up. If you are interested in GLP-1 weight loss, please consult Bianca Clinic.
HerePlease also see ▼
※This article is intended for general informational purposes only and is not intended to diagnose, treat, or prevent any specific disease. If you have health concerns, please consult your physician.