明石先生が患者に注入施術を行っている様子

Skin Plus (Celdiem)

SKINPLUS™.

Focus on the skin's foundation! Skin booster with diverse human-derived ingredients

  • Rebuild the skin and approach skin texture improvement.
  • Designed based on human-derived ingredients to minimize allergies
  • Manufacturing technology reduces pain and downtime
明石 仙姫
Supervising Physician
Board Certification in Internal Medicine, Japanese Society of Internal Medicine Senhime Akashi

With deep medical insight cultivated as an internal medicine specialist, I bridge aesthetic surgery, dermatology, and internal medicine. Having spent my childhood in China, I communicate fluently in Japanese, Chinese, English, and Korean. Possessing an international perspective—evidenced by invitations to present at overseas conferences—I actively promote techniques as a Key Opinion Leader (KOL) for GOURI and REJURAN®. My specialty procedures include double eyelid surgery, skin-nurturing boosters, and body hyaluronic acid treatments. My approach leverages the holistic understanding of the body cultivated through internal medicine to guide patients toward natural, healthy beauty.

Unique Initiatives at BIANCA CLINIC

As a pioneer in cosmetic medicine, we approach our patients with reliable techniques.

Skin Plus (CellDiem) is a skin booster developed in South Korea. At Bianca Clinic, we are constantly incorporating new technologies from both Japan and abroad, but we only decide to adopt them after carefully assessing whether they are “truly effective” and “align with the needs of our patients.” Among the many skin boosters available, we determined that Skin Plus (CellDiem) is likely to be highly effective for Japanese skin, which is why we decided to offer it.

At Bianca Clinic, Skin Plus (Celdiem) treatments are performed by doctors with extensive knowledge of skin boosters and advanced injection techniques. While the results of skin boosters can vary significantly depending on the volume injected and the treatment area, we provide customized treatments tailored to each individual’s needs in terms of depth and volume. We offer high-quality treatments designed to help you achieve what you consider to be the “ideal result.”

WEB Reservation
RESERVATION
24-hour reception
Click here for web reservation

Downtime

DOWNTIME
Redness, swelling, pain, and internal bleeding may occur. Although internal bleeding often settles down within a few days to two weeks, it varies from person to person.

Recommended for people like this

RECOMMENDED.
Concerned about dryness and tightness
I want to regain my elasticity and luster.
I want to improve the texture disorder.
Concerned about poor makeup application and makeup breakdown
I want to treat complex skin problems.
I want to improve the quality of my skin from the ground up.

Features

CHARACTERISTICS

What is Skin Plus (Celdiem)?

Skin Plus (Celdiem) is a Korean-developed skin booster designed to improve the overall condition of the skin. Its key feature is its ability to address a wide range of skin concerns, including fine lines, loss of firmness and radiance, and uneven skin texture.

Typically, different skin concerns—such as fine lines and dullness—require treatments tailored to each specific issue. However, with Skin Plus (CellDiem), a single treatment can make fine lines less noticeable while also delivering numerous benefits, including improved firmness and radiance, a brighter complexion, and overall skin texture improvement. Another noteworthy feature is that the treatment is designed with safety in mind, taking into account the risks of immune reactions, inflammation, and allergies.
In Korea, it is called SERDIM, but in Japan it is also called SKINPLUS.

スキンプラス(セルディエム)とは

Focusing on human-derived ECM components to regulate the skin from its structure

Skin Plus (Celdiem) contains a variety of ingredients—including collagen, elastin, and GAGs (glycosaminoglycans)—to provide a multi-layered approach. These ingredients are referred to as human-derived ECM (extracellular matrix) and are based on components extracted from human tissue.
By bringing the skin closer to its original structure, it greatly supports skin restructuring. As time goes by after the treatment, not only does it bring moisture to the skin, but it is also expected to improve skin density and elasticity. Because it is human-derived, it is highly bio-compatible, and the risk of allergic reactions is taken into consideration.

ヒト由来ECM成分に着目して肌の構造から整える

Ingredients are microparticulated to deliver them deep into the skin

Skin Plus (Celdiem) is a formulation consisting of extremely small particles measuring 75 μm. Due to the small size of these particles, it helps reduce discomfort during treatment. Additionally, it spreads naturally within the skin tissue, allowing beneficial ingredients such as collagen to be delivered uniformly and consistently deep into the skin. It is also less likely to cause lumps or swelling after treatment, and recovery from downtime is said to be rapid.

成分を微細粒子化することで肌の奥深くまで届ける

Benefits

MERIT

Unique formulation design enables approach to multiple skin problems

Collagen and other essential ingredients for natural skin are uniquely designed and combined. Multiple skin problems such as spots, freckles, decreased firmness and luster, and lack of elasticity are addressed with a single treatment.

Consideration for risk of immune and allergic reactions

It is of human origin and is designed to take into account immune and allergic reactions by removing cellular components that may cause immune reactions.

Easier to raise the skin texture and maintain the effect.

Skin quality is improved because the ingredients that make up the skin are incorporated and the skin is rebuilt. The “good state” lasts longer as the foundation of the skin is improved.

Recommended Features

KEY FEATURES

How Skin Plus (Cerdiem) Works

It can approach multiple concerns, so there is no need to choose several treatments to undergo. However, since it is a skin booster, it does not promise immediate results, but rather a gradual skin growth.
The effects of the treatment vary depending on the problem. Some people experience changes in all skin problems after one session, while others see the first problem, then the second, and so on, as they repeat the treatment more and more often.
Although we predict how the effects will manifest themselves at the planning stage of the treatment, we will actually flexibly change the approach according to the changes in the skin after the treatment, creating a “customized” treatment that is unique to you.

Skin Plus (Celdiem) or another skin booster?

Skin Plus (Celdiem) is a cutting-edge skin booster often referred to as a “fifth-generation booster.” It goes beyond simply replenishing moisture on the skin’s surface to improve the skin’s overall texture, making it a popular choice for those concerned about fine lines, uneven skin texture, and a lack of radiance.
At Bianca Clinic, we offer a variety of skin boosters, and among them, we recommend Skin Plus (CellDiem) to those seeking not only firmness and elasticity but also a smooth, even complexion. Depending on your specific concerns and skin condition, we can also compare it with other skin boosters and make recommendations.

Strict quality control makes the design more secure to receive

Skin Plus (Celdiem) is a skin booster formulated with human-derived ingredients, characterized by a design that takes the properties of these materials into account. Generally, human-derived ingredients are considered to have high biocompatibility, and the product is designed with allergy risks in mind. Furthermore, Skin Plus (CellDiem) removes cellular components and nucleic acids (DNA and RNA)—which could potentially trigger an immune response—during the manufacturing process. The compatibility of the processed tissue with human cells has also been confirmed through in vitro evaluations. Developed with safety as a top priority through these processes, it is one of the skin boosters that makes it easy to consider treatment with peace of mind.

WEB Reservation
RESERVATION
24-hour reception
Click here for web reservation

Treatment area

TREATMENT AREA

Full face

Treatment Process

TREATMENT FLOW

Counseling and Examination

We listen to your skin concerns and wishes to determine the indications. We will develop a custom-made treatment plan.

カウンセリング・診察

treatment

If you're wearing makeup, please remove it before we begin. We'll inject Skin Plus (Celdiem) while ensuring we have a clear shared understanding of the desired results.

施術

Aftercare

Makeup can be applied immediately after the procedure. If you wish, you can go home after applying makeup.
You can go about your daily activities from the day of treatment. Please refrain from pressure and vigorous massage for about one week.

アフターケア

Schedule of Charges

PRICE LIST
Skin Plus (Celdiem) Price List
Product Name 1 time 3 times
Skin Plus (Celdiem) 115,500 yen 311,900 yen

Surface anesthesia fee: 3,630 yen

WEB Reservation
RESERVATION
24-hour reception
Click here for web reservation
BIANCA CLINICの医師による美容医療のコンセプト
CONCEPT
Beyond the boundaries of aesthetic medicine,
Lifestyle Beautyis
proposed.

Our goal is to move you beyond satisfaction.
Responding to the desire for greater beauty and health,
What can we do for the well-being of our patients?
Providing total beauty to make your life shine,
That is our policy.

Go to BIANCA and you'll find a smile.
That's the kind of place we're aiming for.

Frequently Asked Questions About Skin Plus (Celdiem)

Q&A

What is the Skin Plus (Celdiem) treatment?

It is an injectable procedure based on human-derived ECM (extracellular matrix) components and incorporates collagen, elastin, and other components related to the structure of the skin. It is expected to have various effects such as moisturizing the skin, improving elasticity and luster, improving skin texture such as texture, and reducing fine lines and wrinkles.

How is it different from hyaluronic acid injections?

Hyaluronic acid injections are used to contour the face and fill in depressions. Skin Plus (Celdiem), on the other hand, is a treatment expected to improve skin texture and strengthen the skin’s foundation.

What skin concerns is the Skin Plus (Celdium) treatment suitable for?

It covers a wide range of skin problems and is guided by fine lines and wrinkles due to dryness, decreased firmness and luster, texture disorder, and the appearance of pores.

What is the pace and number of treatments?

Some people notice a difference after just one session, while others may not notice a difference until after several sessions. We recommend a schedule of three sessions per month. Since results vary depending on your condition, please consult with us.

Does Skin Plus (Celdiem) cause pain?

Because it is an injection procedure, it is not painless, but the extremely small particles are designed to be painless. Bianca Clinic also uses a micro cannula to minimize pain.

Can I apply makeup or wash my face right after a Skin Plus (Celdiem) treatment?

Basically, it is possible, but it depends on the treatment area and condition. Regardless of whether or not makeup or face washing is allowed immediately after the procedure, please do not rub the injection site strongly.

When can I start bathing, exercising, etc.?

We will also check your condition after the treatment. Avoid strenuous exercise, drinking alcohol, prolonged bathing, and sauna on the day of treatment.

Can Skin Plus (Celdium) be used in combination with other treatments?

Depending on the treatment, it may be possible to expect more effective results by combining the treatment with other treatments. However, there are cases in which it is difficult to combine the procedures, or the order or timing of the procedures may need to be adjusted. Please feel free to consult with us at the time of counseling.

[Treatment Details] Skin Plus (Celdiem)
Approximate duration and number of treatments: 3 times per month *Depends on the condition.
Redness, swelling, pain, internal bleeding, microscopic nodules, etc.
【Important Notes Regarding Unapproved Medicines】
・This treatment may involve the use of unapproved pharmaceuticals that have not received regulatory approval in Japan.
・Medicines used in treatments are imported through personal import procedures under the supervision of a physician. For details, please refer to the Ministry of Health, Labour and Welfare's "Information on Medicines Requiring Caution for Personal Import."
 https://www.yakubutsu.mhlw.go.jp/individualimport/purchase/index.html
・Except for products that have obtained pharmaceutical approval, there may be no other domestically approved pharmaceuticals containing the same ingredients.
・Serious risks or side effects may not yet be known.
・In the unlikely event of serious side effects, you may not be eligible for the national pharmaceutical adverse reaction victim relief system.
Patients who have undergone this procedure will not be able to donate blood for a certain period of time.

WEB Reservation
RESERVATION
24-hour reception
Click here for web reservation