Letatortide
RETATRUTIDE
“From ”Eating Less“ to an Era of ”Supporting Energy Expenditure”
Obesity Treatment Focusing on Three Receptors
- A New Approach Targeting GIP, GLP-1, and Glucagon and Their Three Receptors
- In addition to appetite suppression and blood sugar control, the focus is also on energy metabolism
- Treatment Plan Involving Weekly Subcutaneous Injections
To maximize your beauty, care for both the inside and outside is essential. We aim to bring advanced anti-aging treatments, such as peptide therapy common overseas, to our Japanese patients. While aesthetic medical approaches may offer more gradual results, they are crucial for building the foundation that supports beauty and youth. We combine nutritional therapy and lifestyle improvements with hormone replacement, peptide therapy, and regenerative medicine to propose personalized treatment plans. We provide long-term support for health and beauty from within.
Based on world-class expertise, we provide medical care tailored to each individual from a cosmetic internal medicine perspective.
The essence of beauty lies not merely in superficial changes, but in fostering health from within the body. Guided by this philosophy, Bianca Clinic actively incorporates advanced approaches—including peptide therapy and nutritional therapy—and is dedicated to providing medical care in the field of aesthetic medicine.
Letatrolide is a medication that is gaining attention as a new treatment option for obesity because it provides multifaceted support for weight management. Although this medication is not yet approved in Japan, based on clinical data reported overseas and the latest medical findings, our board-certified cosmetic medicine specialists—who specialize in the field of cosmetic internal medicine—will assess each patient’s individual condition and carefully determine suitability. We will ask detailed questions about your lifestyle, medical history, and dietary habits, and make recommendations that take into account not only your current physical condition but also your future health.
We place great importance on thoroughly explaining the risks and potential drawbacks of treatment and ensuring that you fully understand and agree to them before undergoing any procedure. Please let us guide you on your journey toward inner health and beauty.
Downtime
DOWNTIMERecommended for people like this
RECOMMENDED.Features
CHARACTERISTICSWhat Is Letrozole?
In contrast, retroltid is a "triple agonist" that acts on three receptors—GLP-1, GIP, and glucagon—and is attracting attention in the field of medical weight loss as a drug that takes a different approach from conventional treatments.
Acts on three types of hormone receptors to support weight loss in multiple ways
By acting on these receptors, retortide exerts a multifaceted effect through multiple pathways—including energy metabolism—in addition to regulating appetite and controlling blood sugar. By influencing various bodily mechanisms, it aims to support weight management.
Designed for once-a-week dosing, making it easy to stick with even for busy people
Treatment begins with a small dose, and the dosage is gradually adjusted under the doctor’s supervision while monitoring your physical condition and treatment progress. At our clinic, we don’t just track changes in your weight; we also pay close attention to your daily lifestyle and physical changes, supporting your treatment at a pace that’s right for you.
Benefits
MERITAddressing both appetite and energy metabolism
Because it not only suppresses appetite but also supports energy metabolism, you can aim for weight management that doesn't rely solely on excessive dietary restrictions or exercise.
Dose adjustments tailored to each individual's condition
Since the doctor will adjust your medication dosage based on your physical condition and progress, you can proceed at your own pace without straining yourself.
Can be done in conjunction with making lifestyle changes
Along with reviewing your diet and exercise habits, we aim to help you develop habits that will make it easier to maintain a healthy body shape even after treatment.
Recommended Features
KEY FEATURESCareful assessment of suitability and follow-up care by a physician
Treatment with retortide is not available to everyone. At our clinic, a physician will conduct an examination before starting treatment and carefully assess your current health status, medical history, medications you are currently taking, BMI, and other factors to carefully determine your eligibility.
In addition, during your initial consultation, we will perform blood tests to assess your condition prior to treatment. After treatment begins, we will continue to monitor your health and any changes in your weight on a regular basis as we proceed with treatment. If you have any concerns or questions, please feel free to discuss them with us during your appointment.
Achieving Long-Term Weight Management Through Lifestyle Changes That Look Toward the Future
To maintain a healthy body weight in the long term, it’s important to adjust your daily lifestyle—such as reviewing your diet and exercise habits—rather than relying solely on medication. If you return to your previous lifestyle after treatment, there’s a possibility that you’ll gain weight again.
At Bianca Clinic, we provide nutritional therapy and lifestyle advice in conjunction with letrozole treatment. We also offer a comprehensive approach to health tailored to each individual’s lifestyle and genetic background, including the Epigenetic Clock—which visualizes your body’s age—and orthomolecular nutrition therapy. Rather than simply tracking temporary changes in numbers, we carefully review your daily lifestyle to prevent weight regain and support efforts focused on long-term health.
Treatment area
TREATMENT AREASubcutaneous tissue in the abdomen, thighs, etc.
Treatment Process
TREATMENT FLOWCounseling and medical examination by a physician
First, we will ask about your concerns and goals, and review your medical history and current medications. After that, a doctor will assess your health, explain the characteristics of the medication, and determine whether Retatolchid is appropriate for you.
Examination and Blood Draw (First Visit Only)
We conduct blood tests before the first administration to assess your physical condition and monitor your treatment progress.
Administration
If the test results show no issues, we will begin administration under the supervision of a doctor or nurse. During the first session, our medical staff will carefully explain and instruct you on how to use the syringe, the administration method, and any precautions to take. We will also provide advice on nutrition and lifestyle habits, offering the support you need to continue your treatment.
Schedule of Charges
PRICE LIST| Prescribed Amount / Notes | Standard rate |
|---|---|
| 4 mg (1st month) Equivalent to 2.5 mg of Manjaro | 73,500 yen |
| 8 mg (2nd month) Equivalent to 5 mg of Manjaro | 115,500 yen |
| 16 mg (3rd month) Equivalent to 7–10 mg of Manjaro | 189,000 yen |
| Blood draw fee First time only | 3,300 yen |
| Consultation fee Only for the initial prescription | ¥12,100 |
※Includes disinfection and needle fees
※Blood tests are available Monday through Saturday only (not available on Sundays or holidays).
Lifestyle Beautyis
proposed.
Our goal is to move you beyond satisfaction.
Responding to the desire for greater beauty and health,
What can we do for the well-being of our patients?
Providing total beauty to make your life shine,
That is our policy.
Go to BIANCA and you'll find a smile.
That's the kind of place we're aiming for.
Frequently Asked Questions About Letrozole
Q&AIs Letrozole covered by insurance?
No, treatment with Letrozole is considered out-of-pocket care and is not covered by insurance. We will explain the treatment details, cost estimate, and administration schedule in detail during your consultation and examination, so please feel free to discuss any concerns you may have regarding the cost.
What is the difference between Letatolchid and Manjaro?
While Manjaro acts on two receptors—GIP and GLP-1—retortide acts on three receptors: GIP, GLP-1, and glucagon. Because their mechanisms of action differ, it is not possible to definitively determine which one is more suitable.
Because retortide acts on a different combination of receptors, it is sometimes considered as a new treatment option.
At our clinic, we carefully assess each patient’s medical history, current symptoms, and physical condition before thoughtfully recommending a treatment plan tailored to their individual needs.
How long does it take to feel the effects of letrozole?
In clinical trials conducted overseas, changes have been reported following continuous administration ranging from several weeks to several months after the start of treatment. At our clinic, we generally recommend continuing treatment for at least three months to half a year, even in the shortest cases; however, since the onset of effects varies from person to person depending on individual constitution and lifestyle habits, our physicians will make the final determination based on your health status and the course of treatment.
Does Letrozole have any side effects?
Side effects reported primarily involve gastrointestinal symptoms such as nausea, vomiting, loss of appetite, and fatigue. These symptoms often appear early in treatment and tend to gradually subside; however, if they are severe or persistent, do not hesitate to consult your doctor immediately.
Please tell me about the downtime associated with Letrozole.
Since Retortido is an injectable medication, there is generally no downtime like that associated with surgery; however, redness or swelling may occur at the injection site. These symptoms usually subside over time. If any concerning symptoms persist, please discuss them with your doctor during your next visit.
Can anyone get a prescription for Letrozole?
We cannot provide treatment to patients who are pregnant or breastfeeding. Additionally, treatment may not be available depending on factors such as BMI, medical history, or medications currently being taken. At our clinic, we conduct a medical examination and blood tests, and our doctors carefully assess each patient’s condition before determining whether treatment is appropriate.
Will I experience a rebound effect if I stop taking letrozole?
If you return to your previous lifestyle after stopping treatment, you may gain weight again. To maintain the results, it is important to review and adjust your lifestyle habits—such as diet and exercise—while you are still undergoing treatment. At our clinic, we provide advice on lifestyle habits in conjunction with your treatment.
Are there any precautions I should take while being treated with letrozole?
It is important not only to manage your weight with medication but also to make lifestyle changes, such as eating a balanced diet and getting moderate exercise. During treatment, you will proceed under your doctor’s guidance while monitoring any changes in your physical condition.
Related Articles
BLOG
[Treatment Details] Retortido
[Estimated Treatment Duration and Frequency] One subcutaneous injection per week *May vary depending on the patient's condition.
[Risks, Side Effects, etc.] Nausea, diarrhea, vomiting, constipation, loss of appetite, increased heart rate, etc.
【Important Notes Regarding Unapproved Medicines】
・This treatment may involve the use of unapproved pharmaceuticals that have not received regulatory approval in Japan.
・Medicines used in treatments are imported through personal import procedures under the supervision of a physician. For details, please refer to the Ministry of Health, Labour and Welfare's "Information on Medicines Requiring Caution for Personal Import."
https://www.yakubutsu.mhlw.go.jp/individualimport/purchase/index.html
・There are no domestically approved drugs containing the same active ingredient.
・As of September 2026, retortide has not been approved in major Western countries, including the United States, and clinical trials regarding its safety and efficacy are ongoing. Therefore, serious risks may not yet have been identified. ・In the unlikely event of a serious adverse reaction, the patient may not be eligible for compensation under the national drug adverse reaction relief program.
