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2026.08.25
What Is Letrortide? An Explanation of a Drug Currently Under Investigation as a Treatment for Obesity
Many people feel that, even when they stick to a healthy diet and exercise routine, they are unable to manage their weight as they’d like. Because factors such as body type, appetite, and lifestyle are intricately intertwined, relying solely on a self-directed diet may not always lead to significant results.
Against this backdrop, “retortide” is being studied as a new option for weight management. Retortide is currently being developed as a drug that acts on multiple receptors involved in appetite, glucose, and lipid metabolism.
At BIANCA CLINIC, we offer consultations on a variety of weight management issues. In this article, we’ll explain the mechanism of action and research findings regarding retatrolide, which is currently under development.
What kind of medication is Letrozole?
Letarotide is a medication that acts on three receptors: GLP-1, GIP, and glucagon. Because it acts on these three types of receptors, it is called a “triple receptor agonist.”
Effects on GLP-1, GIP, and Glucagon
GLP-1 is a hormone that not only stimulates postprandial insulin secretion but also regulates the rate at which food moves from the stomach to the intestines and helps control appetite. GIP is also involved in postprandial insulin secretion and the metabolism of nutrients.
Glucagon is a hormone involved in the release of glucose from the liver, fat breakdown, fatty acid oxidation, and energy expenditure.
A major difference from conventional GLP-1 receptor agonists is that it acts not only on GLP-1 receptors but also on GIP and glucagon receptors. While there are already drugs that act on both GLP-1 and GIP, retatolide is unique in that it also acts on glucagon receptors.
Research suggests that retortide may act on multiple pathways—such as appetite and energy metabolism—by stimulating three receptors simultaneously.
However, a higher number of receptors targeted does not necessarily result in greater efficacy. Since efficacy and the burden on the body vary depending on the dosage and the individual’s constitution, the appropriate medication must be determined based on the individual’s constitution and health status.
What are the expected effects of letrozole?
Clinical trials of retortide have reported reductions in body weight, BMI, waist circumference, and other measures.
In this section, we will explain changes in body weight and other parameters reported to date, based on the results of a meta-analysis of clinical trials.
Weight Loss and Decrease in BMI
A meta-analysis* combining three studies involving a total of 878 participants reported the following mean differences compared to the placebo group*: a change in body weight of −14.33 points, a decrease in BMI of −5.38, and a reduction in waist circumference of −10.51 cm.
*The placebo group refers to a group that uses a placebo (a drug that looks and is used the same way as the active drug but has no therapeutic effect) in order to accurately assess the drug's efficacy. By comparing the placebo group with the active drug group, we evaluate the changes caused by the drug.
Please note that these figures are merely averages derived from the study as a whole. Actual results may vary from person to person depending on factors such as the dosage used, the duration of treatment, initial body weight, and dietary habits. Not everyone will experience the same results.
Changes in blood sugar levels, blood pressure, and other factors
The same study reported reductions in fasting blood glucose levels, HbA1c, systolic blood pressure, and diastolic blood pressure.
Research on retortide is currently underway, as it is characterized not only by its appetite-suppressing effects but also by its ability to influence multiple metabolic pathways.
If you're concerned about weight management, please consult Bianca Clinic.
Laratutide is currently being studied as a new option for weight management that acts on three receptors: GLP-1, GIP, and glucagon. While previous studies have reported changes in weight, BMI, and waist circumference, individual differences in efficacy and safety mean that not everyone will experience the same results.
When it comes to weight management, it’s important to take a comprehensive approach that considers not only your weight but also your muscle mass, body fat distribution, diet, and daily routine. If you have concerns about weight management, please consult Bianca Clinic to explore aesthetic medical options tailored to your health condition and goals.
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[Treatment Details] Retortido
[Estimated Treatment Duration and Frequency] One subcutaneous injection per week *May vary depending on the patient's condition.
[Cost] 73,500–189,000 yen *Varies depending on the dosage. Separate fees for blood tests and consultations apply.
[Risks, Side Effects, etc.] Nausea, diarrhea, vomiting, constipation, loss of appetite, increased heart rate, etc.
【Important Notes Regarding Unapproved Medicines】
・This treatment may involve the use of unapproved pharmaceuticals that have not received regulatory approval in Japan.
・Medicines used in treatments are imported through personal import procedures under the supervision of a physician. For details, please refer to the Ministry of Health, Labour and Welfare's "Information on Medicines Requiring Caution for Personal Import."
https://www.yakubutsu.mhlw.go.jp/individualimport/purchase/index.html
・There are no domestically approved drugs containing the same active ingredient.
・As of September 2026, retortide has not been approved in major Western countries, including the United States, and clinical trials regarding its safety and efficacy are ongoing. Therefore, serious risks may not yet have been identified. ・In the unlikely event of a serious adverse reaction, the patient may not be eligible for compensation under the national drug adverse reaction relief program.
