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2026.07.23
What Is Seldiem Skin Plus? An Easy-to-Understand Explanation of Its Expected Effects, Benefits, and Drawbacks
With deep medical insight cultivated as an internal medicine specialist, I bridge aesthetic surgery, dermatology, and internal medicine. Having spent my childhood in China, I communicate fluently in Japanese, Chinese, English, and Korean. Possessing an international perspective—evidenced by invitations to present at overseas conferences—I actively promote techniques as a Key Opinion Leader (KOL) for GOURI and REJURAN®. My specialty procedures include double eyelid surgery, skin-nurturing boosters, and body hyaluronic acid treatments. My approach leverages the holistic understanding of the body cultivated through internal medicine to guide patients toward natural, healthy beauty.
CellDiem addresses a variety of skin concerns by infusing human-derived ECM components that are integral to the skin's structure. In Japan, it is also available under the name "Skin Plus."
We’ll explain the mechanism, benefits, and precautions of Skin Plus (CellDiem) in an easy-to-understand way, while incorporating the perspectives that BIANCA CLINIC prioritizes in its medical practice.
What kind of treatment is Seldiem?
Skin Plus (Celdiem) is a treatment that involves injecting human-derived ECM components—which play a role in skin structure—with the goal of improving the overall texture and condition of the skin.
"Skin Plus" and "Cell D'Em" are names that refer to the same formulation.
Some of you may be wondering, “Are Skin Plus and CellDiem different treatments?”
It is known as “Celdiem” in South Korea and “Skin Plus” in Japan. In other words, “Skin Plus” and “Celdiem” refer to the same medication; the only difference is the name used in each country.
Skin Plus (Celdiem) is a skin booster designed not only to temporarily replenish moisture on the skin’s surface but also to deliver ingredients that support the skin’s structure and help improve its overall condition.
This differs from hyaluronic acid injections, which are primarily intended to contour the face and adjust its volume.
Injecting human-derived ECM components into the skin
ECM stands for "extracellular matrix," which is a general term for the components that surround cells and support the structure of tissues.
Skin Plus (Celdiem) contains several ingredients involved in skin structure, such as collagen, elastin, and GAGs (glycosaminoglycans).
The basic concept is that injecting these ingredients into the skin creates an environment that promotes moisture and elasticity, thereby supporting the skin's regeneration.
Based on human-derived components, the product is designed with immune and allergic reactions in mind—for example, by removing unnecessary cellular components and nucleic acids during the manufacturing process.
However, we cannot completely rule out the risk of allergic reactions or other issues.
Injecting fine particles tailored to the condition of the skin
Skin Plus (Celdium) is a formulation consisting of fine particles measuring approximately 75 μm.
By reducing the particle size, the product is designed to spread more easily within the skin tissue, thereby minimizing pain during injection and post-treatment swelling.
However, since this is an injection procedure, it does not mean there will be absolutely no pain.
At Bianca Clinic, we assess your skin condition, concerns, and desired results before determining the injection sites, depth, and volume.
Even when using the same product, the final results can vary depending on the injection technique, so we discuss the desired outcome with the patient before proceeding with the procedure.
▶Detailed Information on the Skin Plus (Celdium) Treatment
What kind of results can I expect from Skin Plus (Seldiem)?
With Skin Plus (Celdiem), you can expect improvements in a variety of skin concerns, such as dryness, fine lines, loss of firmness and radiance, and uneven texture.
During consultations, it’s not uncommon for patients to tell us, “I want to address dryness, loss of firmness, and uneven skin texture—all at once.”
Skin Plus (Celdiem) is a treatment that addresses precisely these complex skin concerns with a single formulation.
The main changes you can expect from Skin Plus (Celdium) are as follows:
- Restores moisture to the skin and relieves dryness and tightness
- Aiming for skin that looks firm and supple
- Refines the skin's texture and leaves it feeling smooth
- Makes fine lines caused by dryness less noticeable
- Aiming for a radiant, even complexion
Skin Plus (Celdiem) contains several ingredients involved in skin structure, such as collagen, elastin, and GAGs.
By infusing these ingredients, we address tightness caused by dryness and uneven texture, aiming for moisturized, smooth skin.
It’s also an option for those concerned about a loss of firmness and elasticity. Since it replenishes multiple components related to the skin’s structure, this treatment is recommended for those who want to improve the overall condition of their skin rather than target a specific concern.
However, not all skin concerns will necessarily improve immediately after the injection. The effects may appear gradually, and the timing and extent of the changes, as well as the number of treatments required, vary from person to person.
Keep in mind that even if you have multiple concerns, the changes associated with each one may not necessarily occur at the same time.
At Bianca Clinic, we not only assess your skin condition before treatment but also monitor changes after treatment to determine the best method and timing for your next injection.
Whether Skin Plus (Celdiem) is right for you or if another skin booster would be better depends on your specific concerns and skin condition, so it’s important to consult with a doctor before making a decision.
What are the pros and cons of Skin Plus (Celdiem)?
While Skin Plus (Celdiem) can address multiple skin concerns, it is important to be aware of potential side effects such as pain during injection, bruising, and individual variations in effectiveness.
Benefits of Skin Plus (Celdiem)
- A single formulation that addresses multiple skin concerns
- Helps replenish multiple components involved in skin structure
- Formulation Design That Takes Immune and Allergic Reactions into Account
- The fine particles help minimize pain and post-treatment swelling.
One of the key features of Skin Plus (CellDiem) is that it makes it easy to consult about multiple skin concerns at once, such as dryness, fine lines, loss of firmness and radiance, and uneven skin texture.
Rather than adding volume to the skin or altering its contours, the goal is to improve the skin's condition and texture.
Another key feature is that the process is based on human-derived components and includes a step to remove cellular components and nucleic acids that may be involved in immune responses.
However, as I also explain to patients during their appointments, just because a substance is derived from humans doesn’t mean it’s absolutely safe or that it won’t cause an allergic reaction.
If you have ever had an allergic reaction or have any pre-existing medical conditions, please be sure to let us know before your treatment—even if it seems like a minor issue.
Disadvantages and Precautions of Skin Plus (Celdiem)
- You may feel some pain during the injection.
- Redness, swelling, pain, bruising, and tiny nodules may occur.
- Results and the number of sessions required may vary from person to person.
After the injection, you may experience redness, swelling, pain, or bruising. While bruising typically subsides within a few days to about two weeks, the recovery process varies from person to person.
If your symptoms persist or if you experience severe pain, consult the medical facility where you received treatment as soon as possible.
While some people notice a difference after just one session, others may be advised to undergo multiple treatments. The general guideline is about three sessions per month, but this varies depending on the condition of your skin. Do not decide on the number of sessions or the interval between them on your own; consult with your doctor to determine the best course of action.
If you have any concerns about the post-treatment recovery process or whether this treatment is right for you, please feel free to discuss them with a doctor during your consultation.
Frequently Asked Questions
We answer your questions about Skin Plus (Celdiem)—including its name, ingredients, when you’ll start to see results, and downtime—so you can be well-informed before your treatment.
Q. What kind of treatment is Skin Plus (Celdiem)?
A. This is a skin booster designed to improve skin texture and condition by infusing human-derived ECM components into the skin. It is known as “Celld'em” in South Korea and “Skin Plus” in Japan.
Q. What are the effects and features of Skin Plus (Celdiem)?
A. You can expect improvements in dryness, fine lines, loss of firmness and radiance, and uneven skin texture. While this treatment addresses multiple skin concerns, the extent of the results and the number of sessions required may vary from person to person.
Q. What ingredients are in Skin Plus (Celdiem)?
A. This formulation is based on human-derived ECM components such as collagen, elastin, and GAGs. During the manufacturing process, unnecessary cellular components and nucleic acids are removed to minimize the risk of immune or allergic reactions.
Q. When will I start to feel the effects of Skin Plus (Celdium)?
A. Collagen production is stimulated over the course of 1 to 2 weeks following the treatment, and many people notice a change in their skin texture within 2 to 4 weeks. However, the timing of when these changes are noticeable varies from person to person. Some people notice a difference after just one treatment, while others may need multiple treatments to see a change.
Q. Please tell me about the downtime and side effects of Skin Plus (Celdium).
A. Redness, swelling, pain, and bruising may occur. While bruising usually subsides within a few days to about two weeks, the healing process varies from person to person.
Why not take a fresh look at your skin’s foundation with Skin Plus (Cerdiem)?
When considering Skin Plus (Celdium), it is important to understand the expected changes and risks, and to consult a doctor to determine if it is suitable for your skin condition.
Skin Plus (Celdiem) is a skin booster that delivers human-derived ECM components to comprehensively address issues such as dryness, fine lines, loss of firmness and radiance, and uneven skin texture.
When considering Skin Plus (Celdium), it is important to understand the expected changes and risks, and to consult a doctor to determine if it is suitable for your skin condition.
When I examine patients, I make a point of carefully assessing, one by one, whether Skin Plus (CellDiem) is truly the right fit for their specific skin concerns.
At BIANCA CLINIC, we assess your skin condition and discuss your goals, and then recommend a treatment plan that takes into account how it differs from other procedures.
If you would like to know whether Skin Plus (Seldiem) is right for your concerns, please consult a doctor during a counseling session.
▶Detailed Information on Skin Plus (Celdiem)
▶Bianca Clinic Counseling Reservation Form
