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Re2O (Bunaju) is a treatment that involves injecting a formulation containing human-derived collagen and other ingredients into the skin, with the goal of strengthening the skin’s foundation.

 

Some of you may be wondering, “Are Lituo and Bunaju different?” or “What effects do they have?”

 

In this article, a doctor from BIANCA CLINIC provides an easy-to-understand explanation of how the treatment works, its effects, the areas treated, its benefits, and precautions to take.

What kind of treatment is Rituo Re2O (Bunaju)?

Rituo Re2O (Bunaju) is an injectable treatment that uses human-derived hADM as its main ingredient to replenish the skin with ECM components.

Rituo and Bunaju are the same formulation

Re2O (Rituo) and BNAJU (Bunaju) are the same drug.

 

"Re2O" is the name used in South Korea, while "BNAJU" is the name commonly used in Japan.

 

The reason you’ll find multiple spellings—such as “Rituo,” “Re2O,” “Bunaju,” and “BNAJU”—when searching is because of these differences in the name.

A Skin Booster That Replenishes the Skin's ECM Components

Rituo Re2O (Bunaju) is a collagen preparation whose main ingredient is “human acellular dermal matrix (hADM),” which is purified by removing cellular components from human tissue.

 

Containing Type I and Type III collagen, this product aims to strengthen the skin’s foundation by replenishing the skin with ECM components such as collagen and elastin.

 

In our skin, the ECM (extracellular matrix)—composed of collagen, elastin, and other components—supports the skin’s structure by surrounding the cells.

 

In a sense, it serves as the “foundation” for maintaining the skin’s firmness and elasticity. However, when the condition of the ECM changes—due to aging, for example—it can lead to skin concerns such as loss of firmness and wrinkles.

 

Rituo is a treatment based on the concept of directly replenishing ECM components—such as collagen—rather than simply stimulating the skin to promote collagen production.

 

By replenishing the ingredients that support the skin's foundation, we aim to achieve firm, moisturized, and smooth skin.

A procedure in which the doctor adjusts the injection site and depth

Rituo is a procedure in which the doctor assesses the condition of the skin, the depth of wrinkles, and skin thickness to adjust the volume, depth, and treatment area of the injections.

 

At Bianca Clinic, we use microcannulas with rounded tips to administer injections while taking care to minimize stress on blood vessels and surrounding tissues.

 

Even for similar skin concerns, the most suitable injection method varies from person to person. To achieve a natural-looking result, it is important to determine the treatment plan not only based on the characteristics of the product but also after carefully assessing the condition of your skin during a consultation.

What kind of results can I expect from Rituo Re2O (Bunaju)?

With Rituo, you can expect it to restore firmness, elasticity, and moisture, and help improve skin concerns such as fine lines and enlarged pores.

 

 

The main changes you can expect from Rituo are as follows:

• Restores skin firmness and elasticity
• Moisturizes and refines skin texture
• Makes fine lines less noticeable
• Aim for smooth skin with less visible pores

Restores skin firmness, elasticity, and moisture

Rituo is a skin booster that directly replenishes the skin with ECM components such as collagen and elastin.

 

It works to address the skin's underlying structure, which has changed due to aging and other factors, to help achieve firm, supple, and hydrated skin.

 

Unlike hyaluronic acid injections, the primary goal is not to add significant volume to specific areas.

 

This treatment is ideal for those who want to achieve natural-looking results while improving the texture of their skin.

Targets skin concerns such as fine lines and pores

You may consider using Rituo for injections to treat fine lines around the eyes, the forehead, the area between the eyebrows, and nasolabial folds.

 

Concerns about dark circles and hollows under the eyes, wrinkles on the neck, enlarged pores, and skin texture are also common reasons for considering a treatment.

 

However, the causes of wrinkles and hollows vary from person to person. During the consultation, we will assess your skin condition and the treatment area to determine whether Lituo is appropriate for you.

 

Depending on the desired results, other treatments—such as hyaluronic acid injections—may be more appropriate.

The effects take time to become apparent.

Rituo is not the type of treatment that produces dramatic changes in facial contours immediately after the injection. Because it works from within the skin, you may notice changes in firmness and texture over time after the treatment.

 

Although the duration of the effects varies from person to person, it generally lasts about six months to a year. The standard approach is to start with about three treatments, spaced one month apart, and then undergo maintenance treatments about once every six months, depending on the condition of your skin.

 

The number of sessions required and the interval between treatments will vary depending on your current skin condition and desired results. During your consultation, we’ll recommend a treatment schedule tailored to your individual needs, so please feel free to ask us for advice.

What are the pros and cons of Rituo Re2O (Bunaju)?

While Lituo can help achieve natural-looking skin changes, there are some precautions—such as swelling, bruising, and restrictions on blood donation—that you should be aware of before undergoing the procedure.

Benefits of Rituo

• Delivers ECM components directly to the skin
• Addresses multiple skin concerns at once
• You can achieve a natural transition without significantly changing the volume.
• Treatments on areas with thin skin, such as around the eyes, can also be considered

What sets Rituo apart is its approach, which not only stimulates the skin to promote collagen production but also replenishes the ECM components that form the skin’s foundation.

 

One of its benefits is that it can address multiple skin concerns—such as firmness, hydration, skin texture, and fine lines—all at once.

 

Furthermore, since the primary goal is not to significantly enlarge specific areas, this option is also considered by those who want to “improve their skin’s appearance naturally without drastically changing their facial features.”

 

The formulation is soft, so even when injected into delicate areas such as around the eyes, there is virtually no risk of unevenness.

Disadvantages and Precautions Regarding Lituo

• Redness, swelling, puffiness, and bruising may occur.
• You may experience pain or a feeling of pressure during the injection.
• The way the effects manifest and how long they last vary from person to person.
• You cannot donate blood for a certain period of time after the procedure.

Since Rituo is an injection treatment, redness, swelling, puffiness, and bruising may occur after the procedure.

 

Rituo is a pharmaceutical product whose main ingredient is hADM, which is derived from human tissue with cellular components removed.

 

Since this product does not contain any animal-derived ingredients, it is designed to minimize the risk of immune or allergic reactions; however, this does not mean that everyone will be free of side effects.

 

In addition, because the treatment uses a preparation derived from human skin tissue, you will not be able to donate blood for a certain period of time after the procedure.

Frequently Asked Questions

Here, we answer some of the questions we’re often asked during counseling sessions.

 

Skin care treatments that go beyond just “adding” something. Aim for natural results with Rituo.

Rituo Re2O (Bunaju) is a skin booster that replenishes the skin with ECM components—including human-derived collagen—to improve firmness, elasticity, and hydration, and help reduce fine lines.

 

While the goal is to achieve a natural-looking result, there are some precautions you should be aware of beforehand, such as swelling, bruising, and restrictions on blood donation. The appropriate treatment areas and injection methods vary depending on the condition of your skin.

 

At BIANCA CLINIC, we listen to your concerns and wishes, examine your skin condition, and then determine the appropriate treatment plan. If you're wondering whether Rituo is right for you, please consult with a doctor during your consultation.

 

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