column (e.g. in newspaper)
2025.08.23
Harmonica Hyaluronic Acid Selection
As an Assistant Professor, Associate Ward Director, and Chief of Dermatopathology at the university hospital dermatology department, I deepened my expertise through academic presentations and paper publications both domestically and internationally. I have handled a wide range of treatments, from birthmark therapy in children to adult pigmentation concerns, utilizing various lasers and injection therapies, while also contributing to community healthcare. Through encountering numerous cases, I strongly felt the potential and necessity of aesthetic medicine, resolving to pursue further expertise. Building upon my solid dermatological knowledge and meticulous diagnostic skills, I value treatments that gently support each individual's skin while bringing out its inherent beauty.
While hyaluronic acid can alter the facial structure itself, with age, bone and fat atrophy, and the supporting ligaments of fatty tissue sag, leading to volume loss and a sunken appearance. Sagging also occurs simultaneously, but even just the sunken look can create a tired, aged appearance. Injections can rejuvenate the face.
Among the many types of formulations available, we will explain the harmonica this time.
I am Dr. Aya Hayama, a board-certified dermatologist.
Harmonica (HArmonyCa) is
Combining calcium hydroxyapatite (CaHA) with hyaluronic acid (HA)A new dual-effect hybrid injection. From France, a pioneer in anti-aging products.AllerganNow available.
Harmonica increases the thickness of the dermis, offering simultaneous improvements in skin volume and rejuvenation. Its effectiveness has already been recognized internationally, with case studies presented at the International Society of Aesthetic Medicine.
Patient satisfaction is also exceptionally high, with reports indicating that 91.61% of patients who received Harmonica injections experienced visible rejuvenation and improved skin texture.
https://www.magonlinelibrary.com/doi/full/10.12968/joan.2023.12.Sup8.S6?utm_source=chatgpt.com
Two Characteristics of the Harmonica
⭐ Instant volume enhancement and lifting effect with hyaluronic acid
⭐Calcium hydroxyapatite's gradual and long-term collagen production promotion effect
Harmonica offers synergistic effects not found in single-agent hyaluronic acid formulations. This includes immediate lifting from the hyaluronic acid and...Calcium hydroxyapatiteThis is the combined effect of stimulating new collagen production and providing sustained collagen stimulation.
Volume-Up Data via Vectra
https://biancaclinic.jp/treatment/faceline/forehead/harmonyca/
Synergistic effect of adding hydroxyapatite (CaHA) to hyaluronic acid
Not only does it add volume, but it also targets "skin texture improvement" and "long-term effects."
| The Role of Hyaluronic Acid | The Role of Hydroxyapatite |
|---|---|
| High moisture retention → Provides elasticity | Stimulates fibroblasts → Promotes collagen and elastin regeneration for skin-nurturing effects |
| Instant volume effect | Medium-to-long-term structural improvement and increased skin density |
| Rapid biodegradation (several months to half a year) | Long-lasting effects (6 months to over 1 year) |
Promotes collagen production
Hydroxyapatite stimulates dermal fibroblasts with its fine particles, promoting the production of collagen and elastin.Therefore, it offers medium- to long-term skin quality improvement effects that cannot be achieved with hyaluronic acid alone.
https://www.magonlinelibrary.com/doi/full/10.12968/joan.2023.12.Sup8.S6?utm_source=chatgpt.com
Enhanced Effect Duration
Hyaluronic acid is absorbed relatively quickly by the body, but adding hydroxyapatite slows its breakdown, making the effects last longer.
Structural support
Hydroxyapatite is the same as the "main component of bones and teeth,"Highly biocompatible, it provides firm support to the dermis and subcutaneous tissue.。
Natural and effortless finish
Hydroxyapatite gradually breaks down after injection, replacing the body's own collagen over time, allowing it to naturally blend into the skin.
Therefore...By combining the two, it is possible to "instantly restore firmness while simultaneously improving skin texture over time."will become.
⭐Achieve immediate volume growth and medium-to-long-term structural improvements simultaneously
⭐To compensate for early volume loss
⭐Significant improvement in skin thickness and lifting effect
In a clinical trial in Brazil, injections combining HA and CaHASkin thickness increased by approximately 9.41 TP3T in 90 days and approximately 18.81 TP3T in 180 days.The procedure was confirmed using high-frequency ultrasound.
https://www.mdpi.com/2079-9284/11/2/61?utm_source=chatgpt.com
Not only the instant effect of volume,Gradually improving the structure to "make the skin stronger and thicker"This is the result that had been occurring.
⭐High beauty effects, satisfaction, and safety
Systematic reviews also conclude that "combining HA and CaHA or using hybrid treatments provides both immediate volume effects and long-term collagen-based improvements, resulting in high satisfaction and excellent safety."
https://link.springer.com/article/10.1007/s00266-025-04904-x?utm_source=chatgpt.com
Additionally, it demonstrates high effectiveness in improving facial contours within 3 to 12 months,Side effects are also very minor.There are also reports that it can be resolved with just that.
https://pubmed.ncbi.nlm.nih.gov/34341855/?utm_source=chatgpt.com
Purpose and Effects of Combination and Concurrent Use
| Effect Category | HA monotherapy effect | CaHA monotherapy effect | When mixed (synergistic effect) |
|---|---|---|---|
| Immediate effect | Strong (Moisture + Volume) | Weak (with initial visual deterioration due to gel absorption) | HA for early appearance stabilization |
| Medium-to-long-term sustainability | It may break down quickly and lose its effectiveness. | Sustained improvement through collagen regeneration | Volume Maintenance + Structural Skin Improvement |
| Improvement of skin quality | Temporary improvement in moisture retention and elasticity | Improvement through collagen and elastin production | Immediate Effects + Sustained Reconstruction |
| Safety and Satisfaction | expensive | expensive | Very high (side effects are minor) |
By the way, I recently had six injections, and people around me have been saying I look rejuvenated and more energetic.
Please feel free to consult us regarding formulations as well.
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