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2025.08.30
Pull Real Densify is also expected to be effective for redness.
As an Assistant Professor, Associate Ward Director, and Chief of Dermatopathology at the university hospital dermatology department, I deepened my expertise through academic presentations and paper publications both domestically and internationally. I have handled a wide range of treatments, from birthmark therapy in children to adult pigmentation concerns, utilizing various lasers and injection therapies, while also contributing to community healthcare. Through encountering numerous cases, I strongly felt the potential and necessity of aesthetic medicine, resolving to pursue further expertise. Building upon my solid dermatological knowledge and meticulous diagnostic skills, I value treatments that gently support each individual's skin while bringing out its inherent beauty.
Pullreal Densify is one of the popular PN formulations, and it has also been shown to be effective in treating flushing (rosacea) accompanied by vasodilation.

I am Dr. Aya Hayama, a board-certified dermatologist.
Pluryal is
Pullreal is a bio-stimulator formulation focused on skin regeneration, developed by MD Skin Solutions in Luxembourg and CE-approved. It is a proven filler used in over 20 countries. Unlike traditional fillers, it does not merely supply moisture or collagen to the skin; it enhances dermal hydration, promotes collagen production, and addresses the skin's own self-repair capabilities.A key feature is its potential to improve skin tone, such as reducing redness.is.
The PULREAL series includes PULREAL Silk, PULREAL Densify, PULREAL Hair Density, and PULREAL BioSculpture, all of which are PN formulations.
Especially in the case of pull-real densification,Polynucleotide (PN) and non-crosslinked hyaluronic acid, mannitol to delay hyaluronic acid degradationcombined "Pluryal DensifyWe recommend the [product name], and our clinic has adopted this system.
The polynucleotide used as the main ingredient complies with EU regulations for manufacturing in Europe and has obtained CE certification. Similar to Rejuran, it contains salmon DNA fragments (polynucleotides). When injected into the dermis, cells perceive this as damage, activating the tissue repair mechanism. During this process, anti-inflammatory effects are exerted, cytokines are released, and collagen proliferation is simultaneously promoted, resulting in tissue regeneration and skin repair.
This treatment utilizes the body's natural wound-healing capabilities, focusing on preventing and repairing skin aging to promote skin regeneration through skin-nurturing injections.
Additionally, by directly injecting hyaluronic acid to increase moisture levels within the dermis, we aim to restore the skin's barrier function and support its self-repair capabilities, thereby improving overall skin health.
The actual effects of Pulliar treatment include improvement in overall skin dullness, reduction of fine lines, enhancement of skin firmness, and improvement in pigmentation and redness (redness associated with chronic inflammation due to antioxidant effects and reduced inflammation).
Expectations for Rosacea
Furthermore, while not the first-line treatment for rosacea, recent reports indicate that for cases where existing treatments or IPL show limited efficacy, the use of similar device-based therapies post-treatment can enhance the results.
However, since temporary worsening may occur, we recommend injections under the guidance of an experienced physician.