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2025.09.14
Achieve a natural rejuvenated look with Renisna injections. Differences from Juvelook and lasting effects.
As an Assistant Professor, Associate Ward Director, and Chief of Dermatopathology at the university hospital dermatology department, I deepened my expertise through academic presentations and paper publications both domestically and internationally. I have handled a wide range of treatments, from birthmark therapy in children to adult pigmentation concerns, utilizing various lasers and injection therapies, while also contributing to community healthcare. Through encountering numerous cases, I strongly felt the potential and necessity of aesthetic medicine, resolving to pursue further expertise. Building upon my solid dermatological knowledge and meticulous diagnostic skills, I value treatments that gently support each individual's skin while bringing out its inherent beauty.
Today, I'd like to introduce you to Renisuna.
I am Dr. Aya Hayama, a board-certified dermatologist.
What is Renisna Injection?
LENISNA is a next-generation collagen booster injection developed in South Korea.The main component is PDLLA (poly-DL-lactic acid).It is a highly biocompatible material made from lactic acid obtained by fermenting starch from corn and potatoes. It has received approval from the U.S. FDA and Korea's K-FDA, confirming its safety and reliability.
In medical settings, it is also used for absorbable sutures and dissolvable thread lifts. Since it does not remain in the body and is slowly absorbed over 1 to 2 years, sustained effects can be expected. After injection, it stimulates fibroblasts to promote collagen production, restoring overall skin elasticity and firmness while tightening pores, improving fine lines, and achieving natural volume enhancement.
FurthermoreRenisuna also contains non-crosslinked hyaluronic acid.This allows you to feel plump firmness and moisture immediately after injection,As time passes, PDLLA stimulates collagen production, leading to long-term rejuvenation effects. Its hybrid skin booster formulation combines immediate results with lasting effects, marking a significant difference from conventional preparations.is.
The Difference Between Renisna and Jubelluck
Jubellook and Renisna are both formulations primarily composed of PDLLA, developed by the same manufacturer, but they differ in their ingredient composition and areas of expertise.
Jubellook is a PDLLA monomer formulationand,A treatment that targets relatively shallow layers to improve enlarged pores and fine linesis.
In South Korea, it has gained explosive popularity as a pore treatment, excelling particularly in improving skin texture.
On the other hand, Renisna is a formulation combining PDLLA with non-crosslinked hyaluronic acid.Non-crosslinked hyaluronic acid provides immediate firmness and hydration, while PDLLA stimulates collagen production for long-term elasticity and volume improvement.will lead to.
Therefore, compared to Jubellook, which specializes in improving superficial texture such as pores and fine lines,Renisuna is a formulation that combines immediate and lasting effects, addressing both volume loss and sagging.It is as follows.
By selecting or combining both options according to your specific concerns, you can achieve a more ideal result.
Renisna combines the immediate volume and hydration provided by hyaluronic acid with the sustained collagen increase delivered by PDLLA. Its greatest feature is the ability to simultaneously achieve both skin texture improvement and rejuvenating effects.
Treatment Method and Process for Lenisna Injections
The physician will administer local injections by hand to the areas of concern or the entire face. PDLLA features a spherical molecular structure designed to gently activate cells while avoiding excessive stimulation, thereby minimizing the risk of inflammation or lumps.
The treatment is typically administered three times at one-month intervals, followed by maintenance sessions every six months to a year. This approach enables sustained skin quality improvement and rejuvenating effects.
Safety and Clinical Evidence of Renisna Injection
Renisna itself is a new formulation, but multiple clinical studies have been conducted on PDLLA and PCL formulations (also components used in absorbable threads), which are similarly used as collagen boosters. Studies using PCL formulations reported a significant increase in dermal collagen density even more than six months after injection*1. Furthermore, research by Beer et al. demonstrated that polycaprolactone formulation injections are effective for wrinkle improvement and also highly safe*2. Furthermore, a review by Gold et al. systematically summarized the scientific evidence for fillers overall, emphasizing that collagen booster formulations are treatments that improve skin quality itself, not merely providing volume replacement*3.
This evidence supports the efficacy and safety of Renisna, which has the same mechanism of action.
Lenisna injections are recommended for people like this
For those dissatisfied with the duration or effectiveness of hyaluronic acid injections, those concerned not only with pores and fine lines but also with volume loss and changes in facial contours, and those seeking long-lasting, natural rejuvenation, Renisna is recommended.
https://bianca-omotesando.jp/medical-spa/fillers-injectables/lenisna/
References
Liu Y, et al. Polycaprolactone-based dermal filler stimulates neocollagenesis and long-lasting volume restoration in human skin. Dermatol Surg. 2016;42(11):1351-1359.
*2 Beer K, et al. A randomized, evaluator-blinded, controlled study of the safety and efficacy of polycaprolactone-based filler for soft tissue augmentation. J Drugs Dermatol. 2019;18(5):426-432.
*3 Gold M, et al. The science and art of dermal fillers: an evidence-based review and update. J Cosmet Laser Ther. 2020;22(1):5-13.
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