Hello!

I am Ayuri Yokoyama, a cosmetic dermatologist and plastic surgeon.
I am also a member of the Society of Aesthetic Medicine.

 

 

 

Peptide therapy, which has recently gained attention in Hollywood and among athletes.
Beauty clinics are beginning to spread in Japan as well.

Peptide therapy involves supplementing peptides that decrease due to lifestyle imbalances and aging, thereby
Anti-aging treatments that support the body's repair and regenerative capabilitiesis.

 

declines with age

・Growth hormone

・Metabolism

・Immune

・Resilience

in order to approach,
“Anti-Aging from the Inside Out”
It is popular as.

 

＜10 Expected Effects of Peptide Therapy＞
・Boost your energy
・Increase muscle mass
・Enhance sexual desire
・Enhance concentration and memory
・Boosts immune function
・Maintaining and supporting hormonal balance
・Relieve joint and muscle pain
・Supports blood pressure function
・Reduce signs of aging
・Support for thinning hair improvement

 

GLP-1 receptor agonists like Mangaro and Liberus, which have now become famous overnight, are also a type of peptide.

 

 

 

■ List of Representative Peptides
*The names are commonly known peptide names, and their approval status as pharmaceuticals varies by country.

 

 

1️⃣ If you're having trouble sleeping
【Melatonin】

 

Who are you?
The "sleep hormone" secreted by the pineal gland.
As darkness falls, its secretion increases, inducing drowsiness and lowering body temperature to promote sleep.

 

What we know (strong evidence)

・Adjustment of circadian rhythms (internal clock)

・Reduced sleep latency (Improved sleep onset）

・Effectiveness for jet lag and shift work sleep disorders

・Antioxidant effect(Free Radical Scavenging)

 

Beauty and anti-aging effects

・Quality sleep Promotion of Growth Hormone Secretion and Skin Regeneration

・Antioxidant effect → Combat photoaging and cellular aging

 

Important Notes

・Supplements are treated differently depending on the country (in Japan, they are classified as pharmaceuticals).

・Overdose or incorrect timing → Daytime drowsiness, headaches, mood swings

・Caution is advised when used in combination with psychotropic drugs or antidepressants.

 

 

 

2️⃣ For whole-body anti-aging, try 【NMN / NAD⁺】

Who are you?
A coenzyme found in cells throughout the body.
Essential for energy production (mitochondria) and DNA repair.

 

What is known

・NAD⁺ concentration decreases with age

・Sirtuininvolved in the activity of longevity-related enzymes

・Animal studies in mice and other species show that increasing NAD⁺ improves metabolism and extends lifespan.

 

Human data

・NAD precursor (NMN) supplements and IV drips

• • Improved Metabolic Balance

  • Reduction of fatigue

  • Improved insulin sensitivity

Reports are emerging that,Long-term safety and true anti-aging effects are still under investigation.。

 

Important Notes

・It is not yet at the stage where one can say "rejuvenation is guaranteed."

・Cancer cells also have active metabolism, so it cannot be definitively stated that "unconditionally increasing NAD is the solution."

 

 

3️⃣ To regain your youth, try 【DHEA】

 

Who are you?
"Maternal hormones" secreted by the adrenal glands.
in the body Testosterone and Estrogen will be converted to, etc.

 

What is known

・Decreases with age (sometimes called the “youth hormone”)

・Studies suggest effects on depressive symptoms, libido, bone density, and metabolism

 

Beauty and Anti-Aging Effects

・Maintaining energy, libido, mood, and muscle mass

・It is theoretically possible that it could affect sebum secretion and skin firmness.

 

Risks and Precautions (Important!)

・As it is a hormone precursor, self-administering supplements is dangerous.
The following risks exist:

　Acne and excessive hair growth

　Menstrual irregularities

　Risk of worsening prostate disease

・Particular caution is required if there is a personal or family history of hormone-related cancers (such as breast cancer or prostate cancer)

 

 

4️⃣ Recommended for guys who lift weights
【Testosterone】

Who are you?
The primary male hormone (present in small amounts in women as well).
Muscle mass, bone density, sexual function, motivation, and erythropoiesis.

 

What is known

・Decreases with age in men → LOH syndrome (male menopause)

・As a supplement therapy,

　Sexual desire, vitality, bone density, and muscle strength improvedThere are examples of doing so.

・Overdose or improper administration may pose the following risks:

　Polycythemia (thrombosis risk)

　Dyslipidemia

　Increased risk of benign prostatic hyperplasia and prostate cancer

 

Beauty and Body Sculpting Effects

・Muscle gain・Body fat reduction → Visible rejuvenation

・However Doping, self-injection, black market products That's completely out of line.

 

 

5️⃣ For enhanced focus, try 【Semax】

Who are you?
Research and use in countries such as Russia Synthetic Peptide。
Originally derived from a portion of ACTH (adrenocorticotropic hormone), this is a heptapeptide.

 

Expected effect

・Memory, concentration, learning ability, language fluencySupport for

・Anxiety or depressive statesApproach to

・Ischemic stroke, ADHD (attention deficit hyperactivity disorder), opioid withdrawal assistance

・Adjuvant therapy for neurological disorders such as ALS (amyotrophic lateral sclerosis), Parkinson's disease, and Alzheimer's disease

 

Current State of Evidence

・Most are Russian-language literature and local trials, with few large-scale international RCTs

・Not commonly used as a pharmaceutical in Japan or Western countries

・It is famous as a "brain-boosting peptide," butSafety and long-term data for general use are insufficient.

 

6️⃣ To boost libido, try 【PT-141】

Who are you?
Melanocortin receptor agonist peptide.
In the United States,Approved as a treatment for female hypoactive sexual desire disorder is being done.

 

effect

・Enhances blood flow and sexual arousal signals

・Supporting improved sexual satisfaction

・Increased erectile strengthSubsidy for

・Treatment for decreased libidoPurpose

・Support for satisfaction with sexual intimacy with your partner

 

 

Side effects

・Nausea

・Headache

・Increased blood pressure

・Facial flushing, etc.

 

 

Important Notes

・Obtaining or self-administering through non-official channels is far too risky and completely out of the question.

・However, self-procurement and use for "cosmetic or recreational purposes" is dangerous.

 

 

7️⃣ For anti-aging care and healing promotion, try 【BPC-157】

Who are you?
A synthetic peptide based on a peptide fragment originally believed to exist in the stomach.
A wide variety of effects have been reported at the animal testing level.

 

Effects reported in animals

・Protection of the digestive tract, repair of the gastric and intestinal mucosa

・Promotes healing of tendons, bones, skin, ligaments, and muscles

・Anti-inflammatory effect

・Pain reduction

・Promoting recovery and healing from surgical procedures

 

Risk

・Not approved as a pharmaceutical product

・Purity and ingredient labeling of online products cannot be guaranteed

・The effects of long-term administration are unknown.

 

 

8️⃣ For fat burning and energy boost, try 【5-Amino-1MQ】

Who are you?
A low-molecular-weight compound being researched as an NNMT inhibitor.

 

effect

・Aids in fat metabolism,Restoration of fat burning and promotion of lipolysis

・Affects fat metabolism and may influence blood sugar levels

・Maintaining vitality and involvement in energy production

 

 

Risk

・Primarily preclinical research using mice and other animals

・Safety and efficacy data in humans are still limited

・Often marketed online as "dream weight-loss drugs" or "ultimate fat-loss solutions," but caution is needed regarding usage.

 

 

9️⃣ If you want to increase muscle mass, try 【LGD-4033】

Who are you?
A type of SARM (selective androgen receptor modulator).

 

 

Effect

・Increased muscle mass and staminapromote

・Improved fat metabolismFat reduction by

・Maintain bone healthfor supplementary purposes

・Supports maintaining mental vitality and concentration

・Post-workout recoverysupport

 

 

Current situation

・Several clinical trials have reported increases in muscle mass and other benefits.
There are concerns regarding safety and long-term risks,It has not yet been approved as a pharmaceutical product.。

・Included in the list of prohibited substances (WADA List).

・Products circulating online as “supplements” are,

• • Ingredient mislabeling

  • excessive amount

  • Other steroid contamination
    such as... are frequently reported,Extremely dangerous。

 

Risk

・Suppression of the testosterone axis (decreased endogenous hormone levels)

・Liver dysfunction

・Concerns regarding effects on spermatogenesis, etc.

 

 

🔚 Key points and important considerations throughout

 

①Melatonin, NAD, DHEA, Testosterone

Hormones and metabolites naturally present in the body

When used correctly, it can be very useful, butTampering with it on your own can risk disrupting your hormone balance.is large

 

 

②Semax・PT-141・BPC-157・5-Amino-1MQ・LGD-4033

Most are compounds in the "research stage/limited use" category.

It's trending in the beauty and anti-aging world,
→ Long-term safety and its status as a pharmaceutical drug have not been established, so prescribing it casually is dangerous.

Especially SARMs and unapproved peptides,
Online shopping / Self-injection is completely out of the question.

 

 

③ Opinion as a Cosmetic Internal Medicine Specialist

Weighing the benefits against the risks,Use only the absolute minimum necessary to achieve the goal.

When implementing,

• • Pre-procedure blood test

  • Hormone, Metabolism, and Liver/Kidney Function Check

  • Regular Follow-Up

　　　　is essential!!!

 

■ Benefits of Peptide Therapy

→Optimize your own hormonal function

・ Relatively low risk of side effects
・ Aim for natural improvement in physical condition

→ Addressing a wide range of concerns from young adults to middle-aged and older adults

・Beauty, weight loss, fatigue, sleep, and more.

 

■ Disadvantages and Precautions of Peptide Therapy

Scientific evidence is still developing.

There is a great deal of promising research,
Approval status and evidence as pharmaceuticals vary depending on the effect.

→Quality issues with supplements and overseas products

Many products lack guaranteed ingredient concentrations or purity.
→→ Use in medical institutions is mandatory!!!

 

■ Who is this for?

• I have chronic fatigue.

• I want to improve the quality of my sleep.

• I want to make my diet more efficient.

• I want to improve my skin's firmness and elasticity.

• We want to enhance the effectiveness of aesthetic medicine.

• Business professionals who want to maintain their stamina and concentration

• People in their 30s to 60s who want to pursue anti-aging

 

Peptide therapy is not about “external beauty,”
“As a foundation-building exercise
A highly effective approachis.
If you're struggling with persistent fatigue, shallow sleep, or wanting to boost your metabolism—this is especially recommended for those facing multiple concerns.
If you're interested, please feel free to contact us for a consultation.

 

 

We are currently running an Embrace Campaign.

Details here↓

https://biancaclinic.jp/recommend/45299/

If you're interested, please feel free to come in for a consultation.
We warmly welcome you to visit our clinic for counseling alone.

 

 

Reservations can be made here.

Complete your reservation in 60 seconds ▶︎

 https://reservation.medical-force.com/b/d7bb811e-ebd5-4b93-93f8-588864b24f15

 

【Profile】

Plastic Surgeon/Cosmetic Dermatologist Dr. Ayuri Yokoyama

Japan's Leading Clinic for Beauty and Health Regenerative Medicine｜BIANCA CLINIC GINZA/OMOTESANDO　

In my previous role, I was involved in establishing a clinic as a cosmetic dermatologist, from its inception to opening, and served as its director for three years.
Having worked with approximately 20,000 patients' skin and faces, contributing to the clinic's development.

To further expand the scope of treatment, I have now transitioned to BIANCA CLINIC, a leading aesthetic and regenerative medicine clinic in Japan.

We provide the latest aesthetic medical treatments for well-aging, encompassing not only cosmetic dermatology but also cosmetic surgery and internal medicine.

 

【Career】

2020 Graduate of the School of Medicine, Hiroshima University

2020: Worked at JCHO Tokyo Shinjuku Medical Center and affiliated hospitals (National Center for Global Health and Medicine Hospital, Tokyo Yamate Medical Center)

2022: Joined ELM Medical Corporation Served as Director of Azabu Clinic

2025: BIANCA joins the company

【Professional Affiliations/Qualifications】

The Japanese Society of Aesthetic Dermatology

Japanese Society of Anti-Aging Medicine

Occupational Physician Certification

【SNS】

Instagram account　

https://www.instagram.com/dr.airi