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2024.06.08
Is Rejuran really that painful? A doctor explains the concerns and countermeasures you should know before treatment
With deep medical insight cultivated as an internal medicine specialist, I bridge aesthetic surgery, dermatology, and internal medicine. Having spent my childhood in China, I communicate fluently in Japanese, Chinese, English, and Korean. Possessing an international perspective—evidenced by invitations to present at overseas conferences—I actively promote techniques as a Key Opinion Leader (KOL) for GOURI and REJURAN®. My specialty procedures include double eyelid surgery, skin-nurturing boosters, and body hyaluronic acid treatments. My approach leverages the holistic understanding of the body cultivated through internal medicine to guide patients toward natural, healthy beauty.
Have you heard the rumor that Rejuran is quite painful?
Some reviews even say, "It's too painful to keep going."
Many people want to try it for its skin-beautifying effects, but they're also worried about the pain, aren't they?
This time, Dr. Senki Akashi of BIANCA CLINIC explains the expected effects of Rejuran, the causes of pain, and methods to reduce discomfort.
BIANCA Akashi Senki, MD Profile
Spent childhood in China and is trilingual in Chinese, Korean, and Japanese. After graduating from Nagoya University School of Medicine, she specialized in internal medicine with a focus on diabetes and endocrinology, becoming a board-certified internist. Subsequently, she gained experience performing over 5,000 surgical procedures and injectable treatments at a major cosmetic surgery clinic, later serving as director of a clinic in central Tokyo. She specializes in eye area surgeries, particularly double eyelid suture procedures and dark circle treatments. Currently at BIANCA Clinic, he supports patients in achieving a naturally beautiful glow from the inside out, encompassing all aspects of cosmetic surgery, medical aesthetics, and cosmetic dermatology.
<Professional Affiliations and Qualifications>
・Japanese Society of Internal Medicine Board-Certified Internist
・Japanese Diabetes Society
・Japanese Society of Aesthetic Plastic Surgery
・Japanese Society of Anti-Aging Medicine
<Check out more information about Dr. Akashi Senki's Aesthetic Medicine here>
Dr. Akashi Senki's Instagram account isHere
The official Instagram account for BIANCA isHere
The official YouTube account for BIANCA isHere
Why is Rejuran said to be "very painful"?

Hello.
I am Senki Akashi of Bianca Clinic.
When it comes to Rejuran, many people probably have the impression that it's "quite painful."
While pain perception varies from person to person, this article explains the characteristics of Rejuran and the reasons why you might feel pain during Rejuran injections.
What kind of skin booster is Rejuran?

Rejuran contains the active ingredient Polynucleotide (PN) One of the skin booster formulations primarily composed of [main ingredient].
PN is also known as the "salmon injection" because it is made from salmon-derived components. Generic versions like "Lizne" and the German-made "Pullreal Densify," which uses high-purity PN, are also part of this category.
Actually, the history of PN preparations is quite long,It has been used for diabetic foot gangrene since the 1950s.It's a time-honored formulation that has been used in clinical settings long before it found its way into the aesthetic medicine field.
Next, regarding the mechanism of action.
Rejuran improves blood flow to create an environment where nutrients can easily reach the skin.
It also suppresses inflammation and activates cells that produce growth factors and collagen, boosting overall skin regeneration! It energizes collagen-producing cells (fibroblasts) to help restore skin firmness and elasticity.
As a result, the following effects can be expected.
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Restore firmness and elasticity to thinning skin
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Improvement of fine lines
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Enhance skin texture from the foundation up
Treatment guidelines Three times per month. After that, we recommend maintenance every six months.
Two Types of Pain You May Feel During Rejuran Injections
There are two types of pain you may feel during the Rejuran treatment.
First,The sharp prick when pricked by a needle。
The second one is,Pain caused by internal pressure when the medication is injected into the skinis.
The pain from the needles can be reduced by using ultra-fine ones, but Rejuran's unique"High viscosity"However, it may be a factor that intensifies the pain felt during drug injection.
Even with intense pain, the results are compelling

Rejuran hurts! Yet it's still highly regarded—and the reason is undoubtedly itsSkin Regeneration Power and Firmnessis.
It has been a long-standing standard in cosmetic medicine in South Korea.
On the other hand, there are also many who say, "It hurts too much to continue with Rejuran."
At Bianca Clinic,By reducing discomfort, we aim to help everyone comfortably continue their Rejuran injections.
What is the “Pain-Free Rejuran” developed exclusively by Bianca Clinic?

Rejuran is not a treatment that dramatically changes skin texture in a single session. For skin texture improvement and anti-aging care, continued use over a period of time is recommended.
Especially completing the first course (approximately 3 sessions) thoroughly is key to maximizing Rejuran's potential.
The situation where "it hurts too much to continue"What a waste!
Therefore, at Bianca Clinic,We carefully select needle thickness and injection methods to minimize discomfort.。
Also, as neededAnesthetic cream and cooling treatments can also be used in combination.
For those sensitive to pain or experiencing significant anxiety, we provide thorough explanations during the pre-treatment consultation and implement appropriate measures before proceeding with the procedure. Please feel free to discuss any concerns you may have.
▼Check out Bianca Clinic's innovative “Pain-Free Rejuran” here
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Summary|If you're concerned about Rejuran's discomfort, please consult Bianca Clinic.
While some individuals find Rejuran's pain to be intense, it may be possible to reduce discomfort through adjustments to the needles or injection technique, or by using anesthetics.
Since Rejuran is a treatment that requires ongoing sessions for skin quality improvement and fine wrinkle reduction, it's crucial to choose an environment where you can attend without stress, without overly worrying about pain.
"Cosmetic medicine doesn't have to be about enduring discomfort"—it's about "treatments that are easy to access and maintain."
First, please schedule a consultation at Bianca Clinic.
※This article is intended for general informational purposes only and is not intended to diagnose, treat, or prevent any specific disease. If you have health concerns, please consult your physician.
