column (e.g. in newspaper)
2025.07.30
Targeted Cool Pain-Free Skin Treatment
As an Assistant Professor, Associate Ward Director, and Chief of Dermatopathology at the university hospital dermatology department, I deepened my expertise through academic presentations and paper publications both domestically and internationally. I have handled a wide range of treatments, from birthmark therapy in children to adult pigmentation concerns, utilizing various lasers and injection therapies, while also contributing to community healthcare. Through encountering numerous cases, I strongly felt the potential and necessity of aesthetic medicine, resolving to pursue further expertise. Building upon my solid dermatological knowledge and meticulous diagnostic skills, I value treatments that gently support each individual's skin while bringing out its inherent beauty.
Target Cool is great news for those who are hesitant about pain and downtime with skin boosters!
We can also introduce a similar formulation to the dermal-epidermal junction here, so I would like to introduce it to you.
I am Dr. Aya Hayama, a board-certified dermatologist.

Target Cool is a medical beauty device gaining traction as a trend in the beauty industry, utilized in 30 countries worldwide, primarily in Korea and Europe. Its key feature is the high-speed injection of low-temperature CO₂ gas, enabling instantaneous and precise control of cooling temperature and duration. It is used for various purposes, including instantly forming medications into microscopic ice needles for introduction into the skin, reducing inflammation through cooling, and improving skin texture via CO₂ infusion.
By replacing the tip nozzle, the device sprays and delivers the medication along with CO₂ gas into the skin.Boosting ModeInject CO₂ refrigerant to alleviate pain and inflammation.Cooling ModeInjecting cryogenic CO₂ refrigerant to destroy diseased tissueFreezing ModeFeatures three functions.
BIANCA CLINIC offers treatments using Boosting Mode and Cooling Mode.
Boosting Mode
Among the features of Target Cool, the Boosting Mode is particularly noteworthy.
*The recommended treatment interval varies depending on the medication.



Cooling Mode
*For acne treatment, the recommended treatment interval is once a week.
*Bohr effect... A phenomenon where hemoglobin's ability to bind or release oxygen changes depending on the concentration of oxygen and carbon dioxide in the blood. As CO2 increases, hemoglobin becomes more readily able to release oxygen, resulting in more O2 being absorbed by tissues that require oxygen.
・I dislike the pain associated with skin-nourishing injections or skin treatments
・Want to undergo skin treatments without worrying about downtime
・Interested in treatment using advanced medical equipment
・Aiming for immediate skin improvement
・Want to efficiently deliver skin boosters* into the skin
・I want to improve my acne-prone skin
*Penetration... Microparticles of the cooled solution accumulate at high concentrations at the DEJ (dermal-epidermal junction), then penetrate into the dermal layer.
Noticeable skin changes right after treatment! Also take note of the Bohr effect.
Target Cool delivers medication directly to the dermis at a depth of approximately 0.3 to 0.4 mm below the skin surface. Since this is shallower than manual application, you can feel changes in your skin immediately after treatment. Another key point is that Target Cool non-invasively introduces CO₂ from the epidermis and dermis into the capillaries. When CO₂ reaches the capillaries via TargetCool, the pH within red blood cells changes, making it easier for oxygen to dissociate from hemoglobin. ThisBohr effectis.Increased oxygen release to tissues promotes metabolism and regeneration while offering anti-inflammatory effects.Yes, I can.
No downtime worries! Especially recommended for those who dislike pain.
Target Cool delivers the treatment agent with no downtime. Ice Needling delivery in Boosting Mode is recommended for those who have previously avoided skin booster treatments due to concerns about pain, post-treatment swelling, or bruising associated with downtime.
*However, individuals with allergies to medications or temperature-related allergies may experience redness or itching.
https://biancaclinic.jp/treatment/skin-care/skin_conditions/targetcool/