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2025.08.19
Characteristics of NEAUVIA Hyaluronic Acid
As an Assistant Professor, Associate Ward Director, and Chief of Dermatopathology at the university hospital dermatology department, I deepened my expertise through academic presentations and paper publications both domestically and internationally. I have handled a wide range of treatments, from birthmark therapy in children to adult pigmentation concerns, utilizing various lasers and injection therapies, while also contributing to community healthcare. Through encountering numerous cases, I strongly felt the potential and necessity of aesthetic medicine, resolving to pursue further expertise. Building upon my solid dermatological knowledge and meticulous diagnostic skills, I value treatments that gently support each individual's skin while bringing out its inherent beauty.
NEAUVIA is a hyaluronic acid formulation that is less likely to cause allergic reactions.
I am Dr. Aya Hayama, a board-certified dermatologist.

Actually, after injecting hyaluronic acid preparations, over time the body may recognize them as foreign substances and cause fibrosis,Some individuals develop delayed-type allergies days to years or even decades later.There are a few of them.
This is less about hyaluronic acid itself thanCross-linking agents (chemicals used to stabilize hyaluronic acid) and impuritiesThis is the response to it.
Hyaluronic acid is naturally derived and has high biocompatibility, but this can vary depending on the manufacturing process.
Therefore, Bianca Clinic has introduced the new hyaluronic acid formulation, Newbia. Since the start of clinical trials in 2012, there has been not a single report of delayed-type allergies with Newbia.
Of course, there are other formulations that have never caused delayed reactions, so we would appreciate it if you could consider this as one option.
Cross-linking used in hyaluronic acid formulations
Crosslinking agents used in hyaluronic acid formulations are additives employed to delay the breakdown and absorption of hyaluronic acid within the body. Crosslinking also affects the texture of hyaluronic acid; less crosslinking yields a softer texture, while more crosslinking results in a firmer texture. While crosslinking is crucial for sustaining the effects of hyaluronic acid, the conventional crosslinking agent BDDE has been suggested as a potential cause of complications following hyaluronic acid injections.
NEAUVIA
Contained in general hyaluronic acid preparationsA key feature is the use of PEG (polyethylene glycol) crosslinking instead of the crosslinking agent BDDE (1,4-butanediol diglycidyl ether).PEG is a component used in industries such as healthcare, cosmetics, and food, with a history spanning over 160 years.
And by using PEG,High elasticity, viscosity, and cohesivenessThis enables a more natural finish.
NEAUVIA's lineup consists of four main products, but our clinic carries three of them.
・Volume Up: INTENSE LINE
・Volume Boost and Collagen Activation: STIMULATE LINE
・Anti-aging care and enhanced moisture retention: HYDRO DELUXE LINE
Like other hyaluronic acid products, the injection site varies depending on the viscosity.
⭐What's distinctive here is that,Even with low-viscosity hyaluronic acid, the concentration of hyaluronic acid is high.That is the point.
This should result in a longer duration of effect.
⭐Also,Containing amino acids (glycine, L-proline) promotes skin health, specifically the production of collagen and elastin.Yes, I can.
⭐During colds or similar conditions, immune responses may increase vascular permeability, causing temporary swelling at the injection site due to hyaluronic acid's moisture-attracting properties. However, this occurs less frequently with Newbia.
https://biancaclinic.jp/treatment_category/skin-care/neauvia/
Here's a dermatologist's musings...
There were patients at the university hospital who had paraffin and other substances injected, repeatedly triggering foreign body reactions.
For substances that can be surgically removed or dissolved with hyaluronidase, that would be ideal. However, for those that cannot be handled that way, I feel strongly that physicians must carefully select them before administration.
Since this treatment is specifically designed to enhance your beauty, we strongly recommend selecting high-quality formulations and providing thorough aftercare. Should you experience any issues following your procedure, please do not hesitate to consult with us.