A new hyaluronic acid formulation with high elasticity and viscosity for a natural finish
NEAUVIA
Point1A new hyaluronic acid formulation that uses PEG as a crosslinking agent that is less likely to cause delayed-type allergies
Point2Use 6 different types to achieve volume boost and anti-aging care
Point3High heat resistance allows combination treatment with RF and HIFU on the same day
NEAUVIA
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BIANCA CLINIC's unique initiatives
attempt
Since the start of clinical trials in 2012, Nuvia has
No reported delayed-type allergies
Have you ever had an allergic reaction to a hyaluronic acid injection? In fact, some people develop a delayed-type allergy that occurs some time after the injection of hyaluronic acid.
Therefore, Bianca Clinic has introduced a new hyaluronic acid formulation, Newbia. Since the start of clinical trials for Newbia in 2012, there have not been any reports of delayed-type allergies to date*. You can receive hyaluronic acid injections with peace of mind.
We have also established our own injection technique, the BIANCA METHOD, which is performed by highly skilled doctors. With a precise design that takes into account the balance of the entire face, we have achieved a beautiful and natural finish. Our strength is that each doctor can provide high-level treatment based on the BIANCA Method. Please take a look at the cases of each doctor on the Bianca Clinic website or Instagram.
*As of October 2025
Do you need forest bathing?
Recommended for:
I'm concerned about the additives contained in hyaluronic acid.
I want to raise my nose without surgery
I want to give my E-line a sophisticated look.
I want to improve my jaw and face line.
I want to make natural eye bags
I want to improve moss on my temples and cheeks
Hyaluronic acid experts and beauty experts
Features
Characteristics
What is NEAUVIA?
NEAUVIA is a type of hyaluronic acid preparation.
It is characterized by the use of PEG (polyethylene glycol) cross-linking instead of BDDE (1,4-butanediol diglycidyl ether), a cross-linking agent (additive) contained in general hyaluronic acid preparations.
The use of PEG provides high elasticity, viscosity and cohesion, allowing for a more natural finish.
NEAUVIA's lineup is broadly divided into three types.
・Volume up: INTENSE LINE
・Volume increase and collagen activation: STIMULATE LINE
・Aging care and improved moisture retention: HYDRO DELUXE LINE
At BIANCA CLINIC, we use six types of hyaluronic acid: four types of "INTENSE LINE," "STIMULATE," and the non-crosslinked hyaluronic acid formulation "HYDRO DELUXE." We offer a different type of PEG-crosslinked hyaluronic acid injection using our unique "BIANCA METHOD."
What are the differences between the four INTENSE lines?
We have four types of INTENSE line of Newveer that we use depending on the area you want to improve. All types contain amino acids (glycine, L-proline).
[NEAUVIA INTENSE]
Hyaluronic acid concentration: 28mg/ml
It is the hardest in the series and is also known as a "shape memory filler" because of its very high cohesiveness and viscosity.
Areas to use: Nose, base of the nose, chin, face line
[NEAUVIA INTENSE LV]
Hyaluronic acid concentration: 26mg/ml
This is the hyaluronic acid in the series that is most suitable for adding volume.
Areas of use: forehead, temples, mid-face, nasolabial folds
[NEAUVIA INTENSE RHEOLOGY]
Hyaluronic acid concentration: 22mg/ml
This hyaluronic acid provides just the right amount of volume and is easily absorbed.
Areas to use: Tear trough (the hollow inside the eye)
[NEAUVIA INTENSE FLUX]
Hyaluronic acid concentration: 26mg/ml
This is the softest, smoothest and most viscous hyaluronic acid in the series.
Areas of use: fine lines, under-eye bags
Features of STIMULATE
In addition to the four INTENSE lines, our clinic also offers STIMULATE. STIMULATE is characterized by its 4% calcium hydroxyapatite (CaHA) content. In addition to its volume-boosting effect, it is also expected to activate collagen, leading to firmer skin while shaping it. Calcium particles are smaller than red blood cells and are metabolized in the body.
[NEAUVIA STIMULATE]
Hyaluronic acid concentration: 26mg/ml
This formulation is expected to have volume-boosting and collagen-activating effects.
Areas of use: forehead, temples, mid-face, chin, etc.
Features of HYDRO DELUXE
HYDRO DELUXE is a formulation that combines calcium hydroxyapatite (CaHA) with non-crosslinked hyaluronic acid and amino acids (glycine and L-proline). Unlike regular hyaluronic acid, it does not contain additives that slow its breakdown and absorption in the body, allowing it to spread evenly throughout the injection area for a natural finish. It also increases the skin's moisture retention and is expected to improve skin quality. It can also be used on areas prone to age spots, such as the neck and hands, making it an ideal formulation for anti-aging care.
[NEAUVIA HYDRO DELUXE]
Non-crosslinked hyaluronic acid concentration 18mg/ml
This formulation gives the skin firmness and elasticity while increasing its moisture retention, and can also be expected to provide anti-aging care.
Areas of use: Face, neck, hands, etc.
What is the cross-linking used in hyaluronic acid preparations?
The cross-linking agent used in hyaluronic acid preparations is an additive used to delay the decomposition and absorption of hyaluronic acid in the body. Cross-linking also affects the texture of hyaluronic acid; fewer cross-links make it softer, and more cross-links make it harder. Cross-linking is important for sustaining the effects of hyaluronic acid, but the traditional cross-linking agent BDDE is said to be one of the causes of problems after hyaluronic acid injection.
NEAUVIA is a new type of hyaluronic acid formulation that uses PEG instead of BDDE as a crosslinking agent. PEG is an ingredient used in the medical field and in the cosmetics and food industries, and has a history of over 160 years. The high elasticity, viscosity, and cohesiveness that are characteristic of NEAUVIA are due to PEG crosslinking.
Benefit
Merit
Merit.1
A more natural finish can be expected
Hyaluronic acid has high elasticity, viscosity, and cohesiveness, so you can expect a natural finish.
Merit.2
Even those who are not compatible with the cross-linking agent BDDE can receive treatment.
"INTENSE LINE" and "STIMULATE" are hyaluronic acid fillers that do not use the cross-linking agent BDDE, so even those who have not been able to use BDDE in the past can receive the treatment.
Merit.3
Addressing facial concerns using four different types of medication
Four different types of hyaluronic acid preparations can be used on different parts of the face, allowing you to address your concerns in a way that suits you.
Treatment site
Treatment Area
Forehead, temples, under-eye bags, tear troughs (hollow areas under the eyes), nose, base of the nose, mid-face, nasolabial folds, chin, jawline, fine lines, etc.
Price list
Price list
Advice from Doctor BIANCA
Advice
■Benefits of PEG
Research has revealed that PEG-crosslinked hyaluronic acid does not change in quality even when exposed to temperatures between -20 and 75°C. On the other hand, literature has shown that BDDE-crosslinked hyaluronic acid lost more than 40% of its hyaluronic acid when exposed to heat at 70°C and 30°C for 60 to 30 seconds. From this, it can be said that NEAUVIA's hyaluronic acid is heat resistant.
Therefore, on the same day that Newbia's hyaluronic acid is injected, RF high frequency, infrared, HYF, and other treatments can be performed. Because it is resistant to temperature changes, hyaluronic acid is not easily broken down even after injection, and the effects can be expected to last for a long time. Another advantage is that it is less susceptible to temperature changes during transportation and storage, making it easier to maintain its quality.
■[Less likely to cause delayed-type allergies] The benefits of low molecular weight PEG cross-linking and two types of amino acids
The low molecular weight PEG crosslinking used in Newbia is designed to be less likely to cause allergic reactions thanks to patented manufacturing technology. In addition, the inclusion of two types of amino acids (glycine and L-proline) is expected to reduce swelling after injection and the absorption of hyaluronic acid. It has also been reported to have anti-inflammatory and active oxygen inhibitory effects, and papers have shown that it is extremely unlikely to cause inflammation after treatment.
More than 2014 million bottles of New Beer have been sold since its release in 700, but there have been no reports of delayed inflammatory reactions or granuloma formation (as of December 2024).
■Hyaluronic acid filler that meets the strict standards of the EU market
Newvia is the world's first hyaluronic acid preparation approved under the European Medical Device Regulation (MDR), and is currently sold in over 80 countries worldwide. IBSA, the manufacturer of Newvia, is a multinational corporation with production bases and subsidiaries in Europe and the United States, and has recently been exhibiting at academic conferences in Japan.
The brand name, Newbia, means "new path." The company is gaining attention in Japan as a contributor to global cosmetic medicine with its hyaluronic acid that uses a different PEG cross-linking method.
Flow of treatment
Content of treatment
01 Doctor's examination/counseling
The area to inject the hyaluronic acid preparation and the amount to inject will be decided. Since NEAUVIA uses different drugs depending on the area to be conditioned, the amount of each drug to be injected will be decided during the consultation.
02 Injection site make-off
You may come to the clinic with makeup on on the day of your treatment, but please remove any makeup from the injection area before the treatment.
03 Treatment
Hyaluronic acid is injected into the desired area. If you are sensitive to pain, we can use anesthesia or a less painful needle.
we also focus on minimizing downtime for treatments.
Downtime
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Frequently Asked Questions Q&A・Notes
Q&A
Treatment details: Injection of hyaluronic acid preparation
Cost: 165,000 yen
Estimated treatment period and frequency: Approximately 9 to 12 months *This may vary depending on the product and area used.
Side effects/risks: redness, swelling, edema, pain, etc.
Regarding treatment using unapproved medical devices and drugs
・This treatment includes medicines that are not approved in Japan or treatments that have a different purpose than that approved by the Ministry of Health, Labor and Welfare.
・Medicines and medical devices used in treatment are imported by individuals at the discretion of our clinic's doctors. Please refer to the following for information on medicines and other items that should be taken into consideration when importing them for personal use.
https://www.yakubutsu.mhlw.go.jp/individualimport/purchase/index.html
- Except for products that have received pharmaceutical approval, there are no other domestically approved drugs or medical devices with the same ingredients or performance.
・Information related to safety in other countries
- CE mark acquired under MDR (European Medical Device Regulation)
・In the unlikely event that serious side effects occur, you will not be covered by the national pharmaceutical adverse reaction relief system.
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