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2026.02.26

What is SERDIM (SkinPlus)? Introduction of a hot new formulation! The difference from Rituo is also introduced in an easy-to-understand manner.

南 寿美
Supervising Physician
Japanese Society of Aesthetic Surgery (JSAS) Sumi Minami

Engaged in both aspects of cosmetic dermatology and cosmetic surgery, he is an all-rounder doctor who pursues natural and elegant beauty with "the best interest of the patient" as his first priority. He is also a member of the Japanese Society of Aesthetic Surgery (JSAS). He specializes in hyaluronic acid injections, thread lifts, and facelift surgery, and is a competent KOL (Key Opinion Leader) for ARTEMISLIFT and Hydro Rejuvenation System. He is always sensitive to the latest trends and is always exploring knowledge and techniques.

セルディエム(スキンプラス) 銀座・表参道にあるBIANCA CLINIC ビアンカクリニック|美容外科・美容皮膚科・再生医療・美容婦人科・美容内科

 

What kind of procedure is "Cerdiem?"
What is the difference between this and "Lituo (Bunaju)?"
We have been receiving an increasing number of such inquiries recently.

 

SELDIM (Skin Plus) is a procedure that is attracting attention as a “next-generation skin booster” that improves the texture of the skin itself. It is not intended to increase the volume of the skin like hyaluronic acid injections, but to improve the firmness and elasticity of the skin to achieve a natural, youthful appearance. In this article, we will explain what SERDIM is, its effects and duration, and the differences between SERDIM and Rituo from a doctor's point of view.

sendiem(Skin Plus)What is it?

CELLERDM is a skin booster treatment based on human-derived ECM (extracellular matrix) components. It is distributed in Korea under the name "cellerdm" and in Japan under the name "SkinPlus," etc. The different names may make them appear to be different treatments, but in fact they are formulations based on the same concept.

 

While conventional hyaluronic acid injections are “volume supplementation,” CELDIM is positioned as “a treatment to improve skin texture itself. By approaching the dermal layer and supporting collagen production, it raises the skin's moisture retention and elasticity. The result is a natural change in the skin that is more like a ”feeling of good skin tone" than an "addition of something".

sendiem(Skin Plus)Characteristics|Approaches to “firmness, not volume

The unique feature of CELDIM is that it does not add volume to the skin, but rather addresses the skin's firmness and elasticity. Unlike procedures that raise the cheeks or change the contour of the skin, CELDYM works to address “the appearance of aging” such as open pores, fine lines and wrinkles, and lack of firmness.

 

...You look somewhat tired.
Foundation does not go on well.
Skin is losing its elasticity.

 

This is an easy treatment to adopt for those who are beginning to experience these age-related changes. The foundation of the skin is being prepared, rather than a showy change - that is the characteristic of SERDYM.

sendiem(Skin Plus)Effects and duration of the change|Changes appear slowly

CELDIM (SkinPlus) is not the type of treatment that gives a significant impression immediately after the procedure, but a change that is felt over time. The overall condition of the skin will be raised by improving firmness and elasticity, reducing the appearance of fine lines and wrinkles and pores, and so on. The effects of the treatment vary from person to person, but it is easier to maintain a more stable condition after multiple treatments. The duration of the treatment also varies depending on skin type and lifestyle, but continued treatment makes it easier to maintain the changes.

sendiem(Skin Plus)Downtime|How will it affect my daily life?

Because SERDIM (SkinPlus) is an injectable skin booster procedure, mild redness and swelling may occur at the injection site immediately after the procedure, but most will settle within a few hours to a few days. In rare cases, internal bleeding may occur due to the use of needles, which will be absorbed naturally over a period of one to two weeks.

 

In most cases, makeup can be applied on the same day, and there is almost no major disruption to daily life. However, we recommend that you refrain from strong massages, prolonged bathing, and strenuous exercise on the day of treatment. At Bianca Clinic, we try to make the procedure as comfortable as possible, and we will explain the downtime to you in advance.

sendiem(Skin Plus)and Lituo (Bunaju)

One of the most common questions we receive from our clients about improving their skin texture is, "What is the difference between Cerdiem and Rituo?" This is one of the most common questions we receive from our customers. Like CellDiem, Lituo is a skin booster based on human-derived ECM (extracellular matrix) ingredients. It is distributed under the name "Re2O" in Korea and "BNAJU" in Japan.

 

Both treatments approach the skin's foundation, but there are differences in the direction they aim and the changes they specialize in.

How to choose between Cerdiem and Rituo? |Hari or Moisture?

SERDIM (SkinPlus) is a treatment that focuses on bringing out the firmness and elasticity of the skin. On the other hand, Lituo (Bunaju) has strength in improving the moisture balance and texture of the skin. Neither is superior to the other, and the choice depends on your skin condition and concerns. For example,

 

Concerned about loss of elasticity → Cerudiem (Skin Plus)

Dryness and texture disorder → Rituo (Bunaju)

 

It is important to make a choice according to the purpose of the procedure. In some cases, we may consider combining the two, but the content and order of the procedures will be decided in consultation with the physician.

 

For more information about ▷Cerdiem (Skin Plus)Here

For more information about ▷Lituo (Bunaju)Here

Who is SERDIM (Skinplus) suitable for? |For those who want to have a natural look

SERDIM (Skin Plus) is suitable for

 

... I'm looking for a natural change.
I prefer a treatment that is not easily noticed by others.
I'm thinking about preventing sagging in the future.
I want to improve the elasticity and firmness of my skin.

 

This treatment is suitable for those who want to improve the condition of their skin rather than make a major impression.

Frequently asked questions (FAQs) about SERDIM (SkinPlus)

To help you consider the procedure with confidence, we have answered the following frequently asked questions about SERDIM (SkinPlus).

Is there any downtime?

Mild redness and swelling may occur, but most likely will settle within a few days.

Is there pain?

A stinging sensation may be felt at the time of injection, but anesthetic cream is generally used.

How many times do I have to take the course to see results?

While some people may notice a change even after just one treatment, in some cases, multiple treatments may be appropriate for more consistent improvement of skin texture. We will suggest the interval and number of treatments according to the skin condition.

How often is the SERDIM procedure performed?

Generally, this is done at intervals of about one month, but it depends on the condition and purpose of the skin. Continuing the process makes it easier to maintain a more stable condition.

Which should I choose, Cerdiem or Lituo?

It depends on your skin condition and concerns. We recommend that you discuss this thoroughly during your consultation. At Bianca Clinic, we carefully examine your skin condition and suggest the best combination for each individual.

The concept of “adjusting the skin from its foundation” with SERDIM

CELLERDM is not a treatment that “changes” the skin, but rather a treatment that “adjusts” it. The goal is to work on the inside of the skin to achieve a natural and effortless transformation.

For those who "don't want to make a big change, but want to look a little more beautiful than before," this is one of the options.

Since SERDIM and Rituo have similar but different characteristics, it is important to choose the right one for your skin condition and purpose. If you are in doubt, consult with us for a consultation to find the best method for you.

 

▷Counseling appointments are available atHere

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