prurial
PLURYAL
Polynucleotides support skin regeneration!
Ageing skin with noticeable redness and lack of moisture
- Skin-nurturing injections focused on slow aging, primarily composed of polynucleotides
- Increase moisture content & support collagen production to enhance self-repair capabilities
- For concerns like dullness, fine lines, pigmentation, redness, and loss of firmness, direct injection into the dermis layer
Guided by the philosophy of "Japanese-quality aesthetic medicine recognized worldwide," we oversee specialized doctor teams across plastic surgery, aesthetic dermatology, aesthetic internal medicine, aesthetic gynecology, regenerative medicine, and permanent makeup. Beyond the clinic, we serve as leaders in roles such as Representative Director of Creation Labo, Producer of Cutting Edge, and Director of the Japan Society of Aesthetic Internal Medicine. Our goal is to deliver not just satisfaction, but profound delight. A game changer in the aesthetic medicine field, proposing Lifestyle Beauty that transcends the boundaries of traditional cosmetic treatments.
KOL-endorsed! Skin-nurturing injections that work on skin tissue and cells to support your skin's self-repair capabilities.
Pluryal is a skin-nurturing injection treatment that supports the skin's self-repair capabilities by acting on skin tissue and cells, aiming to restore and improve skin quality. It is a “biostimulator” formulation that injects nutrients deep into the skin, characterized by its ability to directly target the dermal layer.
Bianca Clinic primarily uses Pluryal® Densify, a combination of polynucleotides (PN), non-crosslinked hyaluronic acid, and mannitol. We also offer Pluryal® SILK and Pluryal® Hair Densify for treatments.
Bianca employs Pluriar's Key Opinion Leaders (KOLs), creating an environment where expertise is shared promptly. This enables every physician to strive for acquiring extensive knowledge and high-level technical skills. If you have any questions about Pluriar treatments, feel free to consult us anytime.
Downtime
DOWNTIMERecommended for people like this
RECOMMENDED FOR:Features
CHARACTERISTICSPullreal
Pluryal is a skin-nurturing injection treatment developed with a focus on prevention and repair, featuring polynucleotides as its main ingredient. It not only increases skin hydration but also supports collagen production by stimulating skin tissue and cells, thereby enhancing the skin's own self-repair capabilities to improve overall skin condition. Expected treatment effects of Pluryal include reducing overall skin dullness, pigmentation, and fine lines, enhancing skin firmness and elasticity, and alleviating symptoms like rosacea and redness (redness associated with chronic inflammation). It is broadly applicable for skin concerns related to aging and decline.
The Purreal series is a formulation developed by MD Skin Solutions in Luxembourg. For manufacturing in Europe, it complies with EU regulations and has obtained CE certification*.
*CE certification … A mark indicating compliance with EU standards for distribution within the European Union.
What is a polynucleotide?
The polynucleotide that forms the foundation of Pulliar is a component extracted from salmon and trout testes. It has been studied for many years for its contribution to skin regeneration and repair. Its key points include supporting skin elasticity and firmness through functions such as activating skin cells and supporting collagen production, while also offering benefits like antioxidant effects and reducing inflammation.
When polynucleotides are injected, cells perceive this as tissue damage, activating the body's repair mechanisms. This process triggers anti-inflammatory effects that suppress cytokine release while simultaneously promoting collagen production, thereby facilitating tissue regeneration and skin repair.
Benefits
MERITA formulation focused on prevention and repair, specialized in regeneration
Pullreal is a treatment that supports the skin's own self-repair capabilities, improving skin condition from the foundation up.
Low allergy risk
The main component, polynucleotide, is known for its high compatibility with humans. Plureal is characterized by a relatively low allergy risk because its enhanced purity ensures complete removal of proteins.
Antibacterial and antioxidant effects can be expected
Polynucleotides extracted from salmon and trout possess high antioxidant properties, helping to suppress oxidative damage and delay skin aging.
Recommended Features
RECOMMENDED POINTSFor skin redness and dryness! Can be combined with other treatments.
Purreal is a treatment focused on skin regeneration that leverages the self-repairing capabilities supported by its main ingredient, polynucleotides. While there are various types of polynucleotide formulations, Purreal is suitable for those concerned with aging skin concerns such as lack of moisture and firmness, as well as redness and rosacea.
At Bianca, we also offer Mesona J and Potenza Melasma (both cheeks) treatments in combination with Prurial Densify and Prurial Silk. Mesona J is a transdermal delivery device that delivers medication to the dermal layer with virtually no pain or downtime. Potenza Melasma is a radiofrequency treatment that suppresses melanin production. If you are interested or would like more details, please consult with a physician or staff member.
Three treatments every two weeks for visible skin changes
While some clients notice skin changes after just one Purreal treatment, repeating sessions makes it easier to maintain improved results. Therefore, Bianca recommends a treatment frequency of three sessions every two weeks. Additionally, while the duration of effects varies by individual, they typically last approximately six months to one year. For consultations, we utilize the high-performance skin diagnostic device “VISIA®”. We use the numerical data to propose an appropriate treatment plan for each patient and provide detailed analysis before and after the treatment.
At Bianca, we offer tailored solutions including Purreal Hair Density for scalp and hair, and Purreal Silk for delicate areas like the eye contour. If you're unsure which treatment suits you best, please consult a Bianca Doctor.
※For details on VISIA®,HereYou can view it from here.
Pullreal used in BIANCA
Pluryal
Pluryal® Densify
(Pull Real Densify)
Indications: Wrinkles, enlarged pores, redness, rosacea, overall skin texture improvement
An injectable formulation combining the main component polynucleotide with non-crosslinked hyaluronic acid and mannitol. Hyaluronic acid helps maintain skin moisture levels, while mannitol calms inflammation and inhibits hyaluronic acid breakdown, enhancing the formulation's longevity. For those concerned about skin redness or rosacea.
Pluryal® SILK
(Pullreal Silk)
Indications: Fine lines, dark circles, skin texture improvement
This CE-certified formulation is specifically designed for the eye area, enhancing skin hydration to promote supple, firm skin. Suitable not only for the eye area but also for delicate areas with thin skin, such as around the mouth.
Pluryal® Hair Densify
(Pull-Real Hair Density)
Indications: Hair thinning, eyebrow and beard volume enhancement
This hair growth formula was developed with a focus on the scalp and hair. Its main ingredient, polynucleotide, is expected to promote blood flow, stimulate growth factor production, and activate hair follicle cells. It can be widely used by both men and women experiencing concerns such as thinning hair, fine hair, and hair loss.
Treatment area
TREATMENT AREAFull face, scalp (Pullreal Hair Density)
Treatment Process
CONTENT OF TREATMENTCounseling
We listen to your concerns and anxieties, then propose a Pluriar treatment plan. If you're worried about pain, please feel free to consult with us.
Makeup Removal / Anesthesia
Before the procedure, you will cleanse and wash your face. An anesthetic cream will be applied to the treatment area and left to take effect.
treatment
Once the anesthesia takes effect, we will inject Purreal. The procedure time varies depending on the treatment area and scope, but it typically takes about 20 minutes to complete.
After the treatment
After the injection, allow sufficient cooling time for sedation. Makeup may be applied starting the day after the procedure.
You may wash your face starting the day of your treatment, but please avoid friction as much as possible. Also, please refrain from strenuous exercise, alcohol consumption, and smoking. Makeup may be applied starting the day after your treatment. Avoid massaging the treated area for about one week. If you are considering other cosmetic procedures that involve strong stimulation, please wait approximately two weeks.
Schedule of Charges
PRICE LISTPull Real Densify
| Part | 1 time | 3 times |
|---|---|---|
| 顔 | ¥77,000 | ¥220,000 |
Pullreal Silk
| Part | 1 time | 3 times | 6 times |
|---|---|---|---|
| 顔 | ¥66,000 | ¥178,200 | ¥316,800 |
Pull Real Hair Density
| Part | 1 time | 3 times | 6 times |
|---|---|---|---|
| 頭 | ¥66,000 | ¥178,200 | ¥316,800 |
Options
| Options | Fees |
|---|---|
| Exosome 1V | ¥55,000 |
| Stem Cells 1V | ¥55,000 |
Lifestyle Beautyis
proposed.
Our goal is to move you beyond satisfaction.
Responding to the desire for greater beauty and health,
What can we do for the well-being of our patients?
Providing total beauty to make your life shine,
That is our policy.
Go to BIANCA and you'll find a smile.
That's the kind of place we're aiming for.
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RECOMMENDED PRODUCTS
Frequently Asked Questions About Pluriar
Q&AIs there any downtime?
Pullreal is known as a treatment with minimal downtime and few side effects. Since it is injected using a syringe, the injection site may feel lumpy for a few hours after the procedure, but this subsides within a few hours. If bruising or swelling occurs, it typically resolves within about one to two weeks.
Is there any effect even after just one session?
Results may vary, but Purreal is renowned as a skin-enhancing injection that delivers noticeable changes even after just one session. Repeated treatments help maintain the effects more easily. While this depends on individual skin conditions, Bianca recommends repeating Purreal every two weeks for a total of three sessions.
Does the Purreal injection hurt?
Pullreal involves injecting the formulation directly into the dermis layer of the skin, so there is some pain associated with the needle insertion. However, at Bianca, we administer anesthesia before the procedure. If you have concerns about pain, please feel free to consult with us.
Can Puru Real be injected under the eyes?
Pullreal Silk is a formulation specifically designed for use under the eyes and on delicate areas. Since we tailor treatments to incorporate patients' preferences and needs, please consult your physician if you wish to use another formulation, such as Pullreal Densify, under the eyes.
What's the difference between Purreal and Rejuve?
Both Pulreal and Rejuran are treatments involving the injection of formulations primarily composed of polynucleotides. For example, Pulreal Densify is said to show results faster and have longer-lasting effects than Rejuran, due to its formulation combining non-crosslinked hyaluronic acid with mannitol. Additionally, Pulreal Hair Density can be injected into the scalp. If you are unsure which treatment is right for you, please consult your physician.
What should I be careful about before and after the treatment?
Please avoid rubbing your skin when washing your face on the day of your treatment. Please shower only and refrain from drinking alcohol, smoking, or strenuous exercise. Makeup and bathing are permitted starting the day after your treatment. Please refrain from massaging the treated area for about one week after treatment, and avoid any beauty treatments considered highly stimulating for about two weeks after treatment.
Are there any cases where the Pulliar treatment cannot be performed?
Pullreal cannot be administered to individuals with fish allergies or fish roe allergies. It is also contraindicated for pregnant or breastfeeding individuals, as well as those with autoimmune diseases. If you have a history of hypersensitivity to Pullreal, treatment is not possible; please inform your physician beforehand.
Can Purreal be applied to areas other than the face?
Some individuals receive Prurial injections to address neck laxity and horizontal wrinkles. Additionally, Prurial Hair Density is indicated for nourishing the scalp and hair follicles, as well as for hair loss care.
【Treatment Details】Pluryal
Recommended Treatment Period and Frequency: Approximately 3 sessions every 2 weeks ※May vary depending on individual condition.
【Risks and Side Effects】Swelling, bruising, redness, etc.
【Important Notes Regarding Unapproved Medicines】
・This treatment may involve the use of unapproved pharmaceuticals that have not received regulatory approval in Japan.
・Medicines used in treatments are imported through personal import procedures under the supervision of a physician. For details, please refer to the Ministry of Health, Labour and Welfare's "Information on Medicines Requiring Caution for Personal Import."
https://www.yakubutsu.mhlw.go.jp/individualimport/purchase/index.html
・Except for products that have obtained pharmaceutical approval, there may be no other domestically approved pharmaceuticals containing the same ingredients.
・Information regarding safety and other matters in other countries
Pluryal® Densify, Pluryal® SILK, and Pluryal® Hair Densify have obtained the European CE Mark.
・Serious risks or side effects may not yet be known.
・In the unlikely event of serious side effects, you may not be eligible for the national pharmaceutical adverse reaction victim relief system.
RESERVATION