Polynucleotides support skin regeneration! For aging skin with noticeable redness and lack of moisture
Pluryal
Point1A skin-growth injection that focuses on slow aging and contains polynucleotides as the main ingredient
Point2Increases moisture and supports collagen production to address self-repair capabilities
Point3Direct injection into the dermis layer to treat dullness, fine lines, pigmentation, redness, and lack of firmness
Pluriel
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BIANCA CLINIC's unique initiatives
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We have a KOL on staff! Skin-growing injections that work on skin tissue and cells to support the skin's self-repairing ability
Plurial is a skin-growing injection treatment that works on skin tissue and cells to support the skin's self-repairing ability, and aims to repair and improve skin quality. It is a "biostimulator" formulation that injects nutrients into the skin, and is characterized by its direct approach to the dermis layer.
At Bianca Clinic, we mainly use "Pluryal® Densify", which combines polynucleotide (PN), non-crosslinked hyaluronic acid, and mannitol, but we have also introduced "Pluryal® SILK" and "Pluryal® Hair Densify" for our treatments.
Bianca has a Plurial KOL (Key Opinion Leader) on staff, and has created an environment where know-how can be shared in a timely manner. Therefore, each doctor strives to acquire a wealth of knowledge and a high level of technique. If you are unsure about Plurial treatment, please feel free to consult us.
Case introduction
Cases
Cases.1
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Treatment name
Plureal
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Our Treatments
Right: After 2 treatments of Plural Densify
Cases.2
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Treatment name
Plurial VISIA01
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Our Treatments
After two treatments, the skin age became 2 years on the right side of the face and 44 years on the left side, making the skin 44 to 13 years younger than before treatment.
Cases.3
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Treatment name
Plurial VISIA02
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Our Treatments
After two treatments, the skin age became 2 years on the right side of the face and 32 years on the left side, making the skin 29 to 6 years younger than before treatment.
Do you need forest bathing?
Recommended for:
I want to improve fine lines around the eyes
I'm worried about dry skin
I want to improve skin redness and uneven skin tone
I want to revitalize my dull skin
I'm worried about dull skin
I want firmness in my skin


Features
Characteristics
What is Plural?
Plural is a polynucleotide-based skin-growth injection treatment developed with a focus on prevention and repair. It not only increases the skin's moisture content, but also stimulates skin tissues and cells to support collagen production and improve the skin's condition by stimulating the skin's own self-repairing ability. The expected effects of Plural include reducing overall dullness, pigmentation, and fine lines, improving skin firmness and elasticity, and easing symptoms of rosacea and redness (redness associated with chronic inflammation). It is suitable for a wide range of skin problems caused by aging.
The Plurial series is a formulation developed by MD Skin Solutions in Luxembourg, and is manufactured in Europe in compliance with EU regulations and has obtained CE certification*.
*CE certification: This mark indicates that the product complies with EU standards for distribution in the EU.

What is Polynucleotide
The polynucleotides that form the basis of Plurial are extracted from the testes of salmon and trout, and have been studied for many years for their potential to contribute to skin regeneration and repair. They work by activating skin cells and supporting collagen production, improving skin elasticity and firmness, while also providing antioxidant and inflammation-reducing effects. It is said that when polynucleotides are injected, cells mistakenly believe they have been damaged, activating the tissue repair mechanism. During this process, an anti-inflammatory effect is exerted, causing the release of cytokines, which simultaneously promotes collagen production, thus approaching tissue regeneration and skin repair.

Choose from three types of formulations to suit your concerns
There are four types of Plurial series, three of which are available at Bianca. Our experienced doctors will suggest the most suitable treatment for your concerns and requests.
・Pluryal® Densify
Indications: Wrinkles, pores, redness, rosacea, overall skin quality improvement
An injectable agent that contains the main ingredient polynucleotide, non-crosslinked hyaluronic acid, and mannitol. Hyaluronic acid is involved in the skin's moisture content and plays a role in retaining moisture, while mannitol calms inflammation and inhibits the breakdown of hyaluronic acid, contributing to the durability of the formulation. For those who are concerned about redness and rosacea.
・Pluryal® SILK
Indications: Fine lines, dark circles under the eyes, improving skin quality
This formulation is CE certified for use around the eyes, and increases the skin's moisture retention, making it supple and firm. It is suitable for use not only around the eyes, but also around the mouth and other delicate areas where the skin is thin.
・Pluryal® Hair Densify
Indications: Thinning hair, adding volume to eyebrows and beard
This is a specialized hair growth formulation developed with a focus on the scalp and hair. The main ingredient, polynucleotide, is expected to promote blood flow, stimulate the production of growth factors, and activate hair follicle cells, making it suitable for both men and women who are concerned about thinning hair, fine hair, and hair loss.







Benefit
Merit
Merit.1
Specializing in regeneration with a formulation focused on prevention and repair
Plurial is a treatment that supports the skin's own self-repairing ability and improves the condition of the skin from the ground up.
Merit.2
Low allergy risk
The main ingredient, polynucleotides, are known to be highly compatible with humans, and Plurial's purity has been increased to completely remove proteins, making it characterised by a relatively low risk of allergies.
Merit.3
Anti-inflammatory and antioxidant effects are expected
Polynucleotides extracted from salmon and trout have high antioxidant properties, and are expected to suppress damage caused by oxidation and slow down skin aging.
Treatment site
Treatment Area
Whole face, scalp (plural hair density)
Price list
Price list
Advice from Doctor BIANCA
Advice
■For redness and lack of moisture in the skin! Can be used in combination with other treatments
Plurial is a treatment that focuses on skin regeneration, taking advantage of the function of its main ingredient, polynucleotide, which supports the skin's self-repairing ability. There are various types of polynucleotide preparations, but Plurial is suitable for those who are concerned about redness and rosacea in addition to skin problems caused by aging, such as lack of moisture and firmness.
At Bianca, we also offer Mesona J and Potenza Melasma (both cheeks) treatments in combination with Plurial Densify and Plurial Silk. Mesona J is a transdermal delivery device that delivers medication to the dermis layer with almost no pain or downtime. Potenza Melasma is a high-frequency treatment that suppresses melanin production. If you are interested or would like to know more, please consult with a doctor or staff member.
■Changes to your skin with 2 treatments every 3 weeks
Some people can feel a change in their skin after just one treatment with Plurial, but repeated treatments make it easier to maintain a better condition. Therefore, Bianca recommends a frequency of Plurial treatments of three times every two weeks. The duration of the effect varies from person to person, but the standard is six months to a year. For counseling, we use the high-performance skin diagnostic machine "VISIA®" to suggest the most appropriate treatment plan for each patient and provide a detailed analysis before and after treatment while looking at the numbers.
At Bianca, in addition to Plurial Densify, we can also suggest formulations tailored to your concerns, such as Plurial Hair Density for the scalp and hair, and Plurial Silk for delicate areas such as around the eyes. If you are unsure which treatment is right for you, please consult with a Bianca doctor.
*For details on VISIA®,CLICK HEREYou can see from the link.
Flow of treatment
Content of treatment
01 Counseling
We will listen to your concerns and worries and propose a Pullial treatment plan. Please feel free to consult us if you are worried about pain.

02 Make-up removal and anesthesia
Before the treatment, please cleanse and wash your face. Apply anesthetic cream to the treatment area and leave it for a while.

03 Treatment
Once the anesthesia has taken effect, the Purial will be injected. The treatment time depends on the area and range of treatment, but it will take about 20 minutes to complete.
04 After treatment
After the injection, you will be given a sufficient cooling period to allow for sedation. Makeup can be applied from the day after the procedure.
You may wash your face from the day of the treatment, but please avoid friction as much as possible. Also, please refrain from strenuous exercise, drinking alcohol, and smoking. Makeup can be applied from the day after the treatment. Avoid massaging the treatment area for about one week, and if you are considering a cosmetic treatment that is highly irritating, please wait about two weeks.
we also focus on minimizing downtime for treatments.
Downtime
Frequently Asked Questions Q&A・Notes
Q&A
[Treatment content] Plurial
[Estimated treatment period and frequency] Approximately 2 times every 3 weeks *Depends on the condition.
【cost】
Plural Densify (Face) ¥77,000
Pullreal Silk (face) ¥66,000
Pullial Hair Density (head) ¥66,000 *This treatment is an elective treatment (not covered by insurance).
[Risks/Side Effects, etc.] Swelling, internal bleeding, redness, etc.
[Caution regarding unapproved drugs]
・This treatment may involve the use of unapproved pharmaceuticals that have not been approved by the Ministry of Health, Labor and Welfare in Japan.
・Medicines used in treatments are imported by individuals under the doctor's discretion. For details, please refer to the Ministry of Health, Labor and Welfare's "Information on medicines and other items that require caution when imported by individuals."
https://www.yakubutsu.mhlw.go.jp/individualimport/purchase/index.html
・Except for products that have received pharmaceutical approval, there may be no other domestically approved drugs containing the same ingredients.
・Information related to safety in other countries
- Pluryal® Densify, Pluryal® SILK and Pluryal® Hair Densify are European CE marked.
-Serious risks or side effects may not be known.
・In the unlikely event that serious side effects occur, you may not be covered by the national Pharmaceutical Adverse Reaction Relief System.
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