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2025.11.08

With so many Rejuran options, which one is best? How to Choose Skin Regeneration Therapy Using Polynucleotides (PN/PDRN)

横山 歩依里
Supervising Physician
Ayori Yokoyama

My journey into aesthetic medicine stems from a desire to help enrich and beautify lives beyond simply treating illness. My specialties include hyaluronic acid, Botox, and thread lifts. I provide treatments that enhance each individual's unique qualities and bring out an elegant, natural beauty. For concerns around the eyes that are difficult to improve with dermatology alone, I also perform surgical procedures. By integrating dermatology and surgery, I holistically balance the entire face. With three periods of overseas study, I am also able to provide consultations in English.

Hello!

I am Ayuri Yokoyama, a cosmetic dermatologist and plastic surgeon.

 

 

Originating in Korea, Rejuran has enjoyed enduring popularity,
Lately, there are so many different types available, and I bet many of you are wondering which one is right for you!

1. What is Rejuran?

Rejuran is a product containing salmon-derived polynucleotides (PN/PDRN).Intradermal Skin Booster Treatmentis.

The following are cited as its mechanism of action and effects:

  • Stimulates fibroblasts → Promotes collagen and elastin production. Source:Lienjang Clinic Korea

  • Improves microvascular blood flow and enhances the skin's regenerative environment.

  • Improves skin firmness, elasticity, and texture; reduces fine lines and pores. Source:Theme: Dermatology

In other words, not fillers like hyaluronic acid (volume-restoring treatments),
“Repair and enhance the skin itself”This is treatment aimed at achieving that.

 

2. Detailed Comparison of Four Types of Rejuran

While names may vary slightly by clinic or country, we introduce and compare four representative types.

 

Rejuran Healer (or Classic)
Target areas: Entire face, neck, décolleté, hands, and anywhere else
Features: The original model. When you think of Rejuran, this is it!
Purpose: Skin texture improvement, firmness, elasticity, pores
Duration: Approximately 6 to 12 months

Rejuran i (Eye)
Target areas: Under the eyes, eyelids, around the mouth, and other areas with thin skin
Characteristics: Low viscosity
Purpose: Dark circles, fine lines, and firming of thin skin
Durability: Slightly shorter compared to other lumber

Rejuran HB (Hybrid/Volumizing/HB Plus, etc.)
Target areas: Entire face, neck, décolleté, hands, and anywhere else
Features: An upgraded version of ①. Contains non-crosslinked hyaluronic acid for superior moisture retention. Includes anesthetic ingredients for pain-free application. Comes in a pink syringe (apparently trending on SNS with comments like "So cute!"). 
Purpose: Skin texture improvement, firmness, dryness
Durability: Approximately 6 to 12 months Compared to other lumber, it tends to last slightly longer.

Rejuran S (Scar) or Tone-Up Booster

Target areas: Acne scars, pitted areas like craters, areas with reduced volume, and neck wrinkles
Features: Highest viscosity in the series.
Purpose: Scar, indentation, and tone improvement; slight volume enhancement
Duration: Approximately 6 to 12 months

 

●Incidentally, the concentration of polynucleotides—a key ingredient in Rejuran—is

①②④ 
polynucleotide


polynucleotide

That's how it is!

 

 

3. Benefits and Selection Guide by Type

①Rejuran Healer (Classic)
Benefits: I want to boost my skin's underlying strength cost-effectively.Ideal for those who...Addresses a wide range of skin concerns, including firmness, fine lines, and pores.
Recommended for people like this: For those who want to start some kind of skin treatment! Your first step.

Rejuran i (Eye)

Benefits: Around the eyes and mouth, where the skin is thinSpecialized for delicate areas
Recommended for people like this For those concerned about fine lines around the eyes, dark circles, thinning skin, and fine wrinkles around the mouth.

 

Rejuran HB/Hybrid
Benefits:Skin regeneration and moisturizingThe Luxury Injection That Can Be Achieved
Recommended for people like this: Skin Care ElevatedFor those who wish to receive it. For those who dislike the discomfort of Rejuran.

Rejuran S/Scar

Benefits: A rare injection effective for dents.
Recommended for people like this: ConvenientlyDepressed scars, craters, acne scar treatmentFor those who wish to do so.

4. Treatment Process, Downtime, and Expected Results

  • Topical anesthesia (approx. 30 minutes) is applied before injection. The procedure itself takes about 10 to 15 minutes.

  • Downtime includes redness, unevenness, and minor bruising. Redness and unevenness usually subside by the next day. Bruising may last 1 to 2 weeks.

  • Regardless of the type of lumber, we recommend continuing the process 4 to 5 times every 3 to 4 weeks. ☺ 
    Duration varies depending on the type, individual differences, and concomitant treatments, but 6 to 12 months is a general guideline. Source:Theme: Dermatology

  • It does not take effect immediately; the effects gradually appear over a period of 4 to 8 weeks.

  • Rather than producing dramatic results immediately on its own, it is recommended to combine it with home care and other treatments for continued use.

5. Summary

Rejuran utilizes salmon-derived polynucleotides.“Skin Regeneration Therapy”as,
For those seeking improved firmness, elasticity, and skin texture, this is a highly effective option.

However, for each type (Healer/Eye/HB/Scar, etc.)Target, purpose, and design differTherefore,
Choosing the type that best suits your skin concerns and goals is the key to enhancing satisfaction.
You can achieve maximum results through comprehensive treatment combining clinic-based care and home care.

 

We warmly welcome you for counseling alone! If you're interested, please feel free to come in for a consultation.

 

Salmon Boost Campaign Now On!

🧬What is Salmon Boost?

Formulated with Rejuran,Bianca Original Special Skin-Nurturing Injection

Boost skin's regenerative power, refine texture, and enhance firmness and elasticity✨

 Regular Price: ¥300,080 → 🉐¥210,056

This campaign runs through the end of November!

 

We are currently running an Embrace Campaign.

Details here↓

https://biancaclinic.jp/recommend/45299/

If you're interested, please feel free to come in for a consultation.
We warmly welcome you to visit our clinic for counseling alone.

 

 

Reservations can be made here.

Complete your reservation in 60 seconds ▶︎

 https://reservation.medical-force.com/b/d7bb811e-ebd5-4b93-93f8-588864b24f15

 

【Profile】

Plastic Surgeon/Cosmetic Dermatologist Dr. Ayuri Yokoyama

Japan's Leading Clinic for Beauty and Health Regenerative Medicine|BIANCA CLINIC GINZA/OMOTESANDO 

In my previous role, I was involved in establishing a clinic as a cosmetic dermatologist, from its inception to opening, and served as its director for three years.
Having worked with approximately 20,000 patients' skin and faces, contributing to the clinic's development.

To further expand the scope of treatment, I have now transitioned to BIANCA CLINIC, a leading aesthetic and regenerative medicine clinic in Japan.

We provide the latest aesthetic medical treatments for well-aging, encompassing not only cosmetic dermatology but also cosmetic surgery and internal medicine.

 

【Career】

2020 Graduate of the School of Medicine, Hiroshima University

2020: Worked at JCHO Tokyo Shinjuku Medical Center and affiliated hospitals (National Center for Global Health and Medicine Hospital, Tokyo Yamate Medical Center)

2022: Joined ELM Medical Corporation Served as Director of Azabu Clinic

2025: BIANCA joins the company

【Professional Affiliations/Qualifications】

The Japanese Society of Aesthetic Dermatology

Japanese Society of Anti-Aging Medicine

Occupational Physician Certification

【SNS】

Instagram account 

https://www.instagram.com/dr.airi

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