column (e.g. in newspaper)
2026.02.26
What is Re2O? Next-generation collagen formulation that “nurtures” the skin!
Engaged in both aspects of cosmetic dermatology and cosmetic surgery, he is an all-rounder doctor who pursues natural and elegant beauty with "the best interest of the patient" as his first priority. He is also a member of the Japanese Society of Aesthetic Surgery (JSAS). He specializes in hyaluronic acid injections, thread lifts, and facelift surgery, and is a competent KOL (Key Opinion Leader) for ARTEMISLIFT and Hydro Rejuvenation System. He is always sensitive to the latest trends and is always exploring knowledge and techniques.

What is Re2O? What is the difference between Re2O and conventional hyaluronic acid? --Recently, we have been receiving an increasing number of such inquiries.
Rituo (Bunaju) is a new formulation that does not “add volume,” but rather “conditions and nurtures the skin itself. It is attracting attention mainly from those who seek a natural change, and Bianca Clinic has newly introduced it. In this article, the characteristics of Lituo (Bunaju), the expected effects, downtime, and costs are explained in an easy-to-understand manner from a physician's point of view. If you are interested in finding out which treatment is right for you, please refer to this article.
Are Re2O and BNAJU different? What are their characteristics and effects?
I was wondering, "What's the difference between Re2O and BNAJU? Different treatments?" You may be wondering, "What is the difference between Re2O and BNAJU? It is a little confusing when there are several names. First of all, we will simply organize the differences.
Are Re2O and BNAJU different? |Actually, they are the same formulation.
In conclusion, we can tell you that Re2O (Re2O) and BNAJU (BNAJU) areSame product, just different nameis.
Re2O is the name used in Korea and BNAJU is the name distributed in Japan. Although the product names and package designs are different, the formulations themselves are identical. Therefore, there is no need to compare Re2O and BNAJU as “different treatments. The internet is confusing because of the multiple references to Re2O, Retuo, BNAJU, and BNAJU, but they all refer to the same formulation.
What kind of treatment is Rituo (Bunaju)? |A new approach to “skin nurturing
The greatest feature of LITUO (Bunaju) is that it is not a procedure to “add volume,” but rather a procedure to “improve and nurture the skin itself. The concept of LITUO (Bunaju) is not to physically increase the height and thickness of the skin like hyaluronic acid injections, but to approach the internal environment of the skin and increase its firmness and elasticity.
By approaching the dermal layer and supporting collagen production and moisture retention, the result is very natural. The goal is to create a change in the skin so that the customer feels “my skin has been feeling good lately,” rather than "I put something in it. It is also suitable for early aging care and prevention of future sagging, and is the treatment of choice for those who value "improvement of skin quality itself" rather than showiness.
Effectiveness and duration of Rituo (Bunaju)|Treatment that accumulates natural changes
The effects of Lituo (Bunaju) are not of the "big change the moment you put it in" type, but rather are felt gradually over time. It works inside the skin to improve firmness and elasticity, improve fine lines and wrinkles, and tighten pores, aiming to raise the overall quality of the skin.
It is also suitable for early signs of aging, such as “looking somewhat tired” or “foundation doesn't go on well,” and since the skin itself is toned rather than contoured, a natural change can be expected. The effects often appear gradually over several weeks, and the duration varies from person to person. In some cases, more stable effects can be expected by performing multiple treatments according to the skin condition. LITUO (Bunaju) is not an "immediate change" but an "investment in future skin. It is a treatment that leads to a natural and steady youthful impression.
Is there any downtime? |Why is it difficult to be noticed?
When considering Lituo (Bunaju), many people are concerned about downtime. Although Lituo (Bunaju) is a relatively low downtime procedure, mild redness and swelling may occur due to the injection treatment. Most will settle down within a few hours to a few days. In rare cases, internal bleeding may also occur due to the use of needles, which will be gradually absorbed over a period of 1-2 weeks. Makeup can often be applied on the same day, and there is little major disruption to daily life.
However, we recommend that you refrain from strong massage, prolonged bathing, and strenuous exercise on the day of treatment. Will people around me notice? However, since LITUO (Bunaju) is not a procedure that causes a sudden change in volume, it is relatively unlikely that people will notice any significant changes. The fact that the procedure aims for a natural change is also a point that reduces concerns about downtime.
Who is suitable? |For those who want to “adjust” rather than “change”.”
Rituo (Bunaju) is a procedure that can address multiple concerns such as open pores, fine lines and wrinkles, and poor skin texture all at once. It is also suitable for those who are afraid of looking unnatural and do not want their appearance to be noticed by others.
It is also an option for those who are experiencing early signs of aging, such as "I look somewhat older these days" or "My skin is losing its elasticity. By adjusting the skin's foundation, it is expected that future changes will be milder. You do not want to make too big a change, but want to look a little more beautiful than you do now. This treatment is an option for such people.
FAQ for Re2O (Re2O/Bunaju)|Frequently asked questions
The following is a list of frequently asked questions we receive from people considering Rituo (Bunaju).
Q1. does rituo (bunaju) hurt?
Since Rituo (Bunaju) is an injection treatment, you may feel a stinging or mild pressure sensation. However, anesthesia cream is used to minimize pain. If you are concerned about pain, please consult us in advance.
Q2. When can I start feeling the effects of Lituo (Bunaju)?
Rituo (Bunaju) is not the type of hyaluronic acid injections that cause significant changes immediately after the procedure. Some patients may feel an immediate firmness immediately after the procedure, but most patients will notice a gradual change in skin texture over several weeks. Because LITUO (Bunaju) is a “nurturing” treatment, natural changes will appear over time.
Q3. How long is the downtime for Rituo (Bunaju)?
Downtime for Rituo (Bunaju) is often relatively mild. In most cases, redness and mild swelling will settle down within a few hours to a few days. However, if internal bleeding occurs, it will take one to two weeks to be absorbed.
Q4. How many times do I need to take Lituo (Bunaju)?
Although changes may be felt even after one session of Rituo (Bunaju), in some cases, multiple sessions may be recommended for more consistent results. The appropriate number of sessions depends on the condition of the skin and the desired result, and will be suggested during the consultation.
Q5. How much does a rituo (bunaju) cost?
The cost of Rituo (Bunaju) varies depending on the amount used, the area to be treated, and the number of times. Therefore, it is difficult to give you a general idea of the cost, but we will carefully explain the necessary details to you and proceed with the procedure only after you have agreed to the terms of the treatment. It is best to think of Rituo (Bunaju) from the perspective of an investment in your future skin.
Re2O (Re2O / Bunaju / BNAJU) “Naturally Aligning” The Re2O (BNAJU) Option
Re2O (Re2O/BNAJU) is a treatment based on a new concept of “toning the skin itself” rather than “rejuvenation by adding volume. Re2O is a new concept of treatment that aims to improve the skin itself, rather than ”adding volume and rejuvenation." It approaches the inside of the skin to improve its firmness and elasticity, while aiming for a natural and effortless change.
This is a suitable option for those who want to accumulate changes that will make them feel that their skin has recently become more beautiful, rather than making a major impression. If you are not sure if this is the right treatment for you, please contact us for a consultation. We will propose a treatment that is easy and comfortable for you according to your concerns and skin condition.
The menu page for ▷Lituo (Bunaju) isHere
▷Counseling appointments are available atHere