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Many of you are probably wondering, “How is this different from applying beauty ingredients topically?” and “What kind of effects does it have?”

Mesona J uses electrical stimulation—without needles—to deliver beauty-enhancing ingredients into the skin. At BIANCA CLINIC, we assess your skin condition and concerns before recommending the appropriate treatment plan and products.

In this article, we’ll explain how Mesona J works, its effects, benefits, and precautions from a doctor’s perspective.

What kind of treatment is Mesona J?

Mesona J is a treatment that uses the mesoporation method—which applies the principle of electroporation—to deliver beauty ingredients into the skin without the use of needles.

Transdermal Delivery Treatment Using Specialized Electrical Pulses

MESONA-J (MESONA-J / Mesoporation) is a transdermal delivery device designed exclusively for medical institutions that utilizes specialized electrical pulses.

The skin has a barrier function that prevents foreign substances from entering from the outside. Therefore, simply applying beauty ingredients to the skin's surface limits how deeply they can penetrate, depending on the type of ingredient and the size of its molecules.

Mesona J is a treatment that utilizes a technology called electroporation to temporarily create pathways for active ingredients to pass through. This allows for the delivery of non-ionized ingredients as well as those with relatively high molecular weights, such as hyaluronic acid.

Uses pen-type and roller-type probes

The treatment consists mainly of two steps.

First, an electrical pulse is applied using a pen-shaped probe to create a pathway for delivering the beauty ingredients. Next, a roller-shaped probe is applied to the skin to deliver the ingredients using electrical force and physical pressure.

Since this procedure does not involve piercing the skin with a needle, there is no bleeding or scarring from a needle. However, you may experience a mild tingling sensation from the electrical stimulation, or—depending on the treatment area—a metallic taste or a sensation of light.

It's important to choose a product that suits your skin type.

At Mesona J, the expected results vary depending on the active ingredients used. We use vitamin C derivatives, tranexamic acid, hyaluronic acid, and vitamins A and B complex, combining them according to each client’s specific skin concerns.

At Bianca Clinic, we assess your skin condition and discuss your goals during a consultation, then recommend the appropriate treatments and a treatment schedule. We do not select treatments based solely on the name of your skin concern; instead, we conduct a thorough evaluation that includes checking for inflammation and allergies.

What kind of results can I expect from Mesona J?

Depending on the active ingredients used, Mesona J addresses multiple skin concerns, such as dryness, dullness, enlarged pores, loss of firmness, and dark spots.

The main changes you can expect are as follows.

• Restores moisture, firmness, and radiance to the skin
• Correct dullness and achieve a brighter complexion
• Treats age spots, melasma, and post-inflammatory hyperpigmentation
• Minimizes the appearance of pores and refines skin texture

Treatments that infuse moisturizing ingredients such as hyaluronic acid are expected to help prevent dryness and restore the skin’s firmness and radiance. While some people notice a difference in moisture levels and how well their makeup applies immediately after the treatment, the degree to which these effects are felt varies from person to person.

Vitamin C derivatives, tranexamic acid, and arbutin are used to address concerns such as dullness, dark spots, melasma, and post-inflammatory hyperpigmentation. Since melasma and redness can be exacerbated by irritation, it is important to assess the condition of the skin before selecting a treatment method.

By combining ingredients such as vitamin A and vitamin B6, you can also address concerns such as visible pores, excess sebum, skin texture, and acne. However, Mesona J alone cannot solve all skin concerns.

The timeframe in which you’ll notice changes and the number of sessions required will vary depending on the type of concern, your skin type, and the treatment used. While you may notice a change in your skin’s texture after just one session, ongoing treatment may be recommended in some cases. During your consultation, we’ll work with you to develop a treatment schedule that fits your lifestyle.

What are the Mesona J treatment plans at Bianca Clinic?

At Bianca Clinic, in addition to the PINK, WHITE, and SA plans, we offer treatment plans tailored to areas with pigmentation, as well as the back and buttocks.

*The following plans are current as of August 2026. For the latest information,Treatments PagePlease check there.

PINK

PINK is a treatment plan that addresses both the face and neck. We often recommend this plan to clients who want to tackle multiple skin concerns at once, such as dark spots, melasma, dullness, dryness, enlarged pores, and loss of firmness. Depending on your preferences and skin condition, we can also add the SA Serum to your treatment.

WHITE

The WHITE plan is designed primarily to address dullness, uneven skin tone, dark spots, and melasma. You can add hyaluronic acid injections for the lips and neck treatments as optional extras.

SA

The SA plan features the SA Serum from “SkinAmure,” a skincare brand developed by Dr. Iwama at our clinic. It is designed to comprehensively address skin concerns such as dryness, dullness, redness, and loss of firmness. It contains high concentrations of glutathione and hyaluronic acid, and there is also an optional treatment for the neck.

In addition, we offer body treatment plans targeting areas prone to pigmentation—such as the knees, elbows, and underarms—as well as the back and buttocks. If you’re unsure which plan to choose, please rest assured. At Bianca Clinic, our doctors will examine your skin condition during a consultation and recommend the most suitable plan for you.

What are the pros and cons of Mesona J?

While Mesona J can deliver a wide range of ingredients without the use of needles, it carries risks such as a stinging sensation, an iron-like taste, and allergic reactions to the medication.

Benefits of Mesona J

• It delivers beauty ingredients without using needles.

• It can handle components with relatively high molecular weights

• You can combine treatments to address your specific skin concerns

• Relatively little downtime

• In many cases, you can apply makeup starting on the day of the treatment.

• Treatments can also be performed on areas other than the face

With Mesona J, it is said that the penetration of active ingredients is approximately 300 times greater than with standard application.

This treatment is a good option for those who are hesitant about procedures that use needles to deliver active ingredients directly into the skin. Additionally, since it does not involve puncturing the skin, it is a viable choice for those who want to undergo treatment with minimal disruption to their work or other plans.

Another key feature is that the active ingredients can be tailored to address not just a single concern—such as dark spots or dryness—but multiple skin concerns.

Disadvantages and Precautions of Mesona J

• I sometimes feel a tingling sensation as if from an electric shock.
• There is a possibility of an allergic reaction to the medication.

• Depending on the area, you may experience a metallic taste or feel a flash of light.

• Depending on the skin concern, multiple treatments may be necessary.

• Treatment may not be possible in some cases due to metal implants or pre-existing medical conditions.

The medications used may cause redness or a stinging sensation. If these symptoms persist or become severe, please consult the medical facility where you received the treatment.

We ask that pregnant women and individuals with implanted electronic devices (such as pacemakers) or metal implants refrain from receiving treatment. If you have severe skin irritation, inflammation, or an open wound that is still healing, a preliminary examination is required.

Frequently Asked Questions

Here are answers to questions we often hear from people considering Mesona J.

▶Mesona J Treatment Page
▶Counseling Appointment Page