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2026.07.26
What Is NanoStem? An Easy-to-Understand Explanation of Its Expected Effects, Benefits, and Drawbacks
With deep medical insight cultivated as an internal medicine specialist, I bridge aesthetic surgery, dermatology, and internal medicine. Having spent my childhood in China, I communicate fluently in Japanese, Chinese, English, and Korean. Possessing an international perspective—evidenced by invitations to present at overseas conferences—I actively promote techniques as a Key Opinion Leader (KOL) for GOURI and REJURAN®. My specialty procedures include double eyelid surgery, skin-nurturing boosters, and body hyaluronic acid treatments. My approach leverages the holistic understanding of the body cultivated through internal medicine to guide patients toward natural, healthy beauty.
NanoStem is an anti-aging treatment that introduces "Silky Fat," derived from your own body fat, into the skin.
Many people probably have questions like, “How is this different from fat grafting?” and “Are treatments using stem cells safe?”
In this article, I’ll explain the mechanism, effects, benefits, and precautions of NanoStem in an easy-to-understand way.
At BIANCA CLINIC, we evaluate each patient’s skin condition, determine whether fat removal is feasible, and assess the physical strain on the body before deciding on a treatment plan.
What kind of treatment is NanoStem?
NanoStem is a treatment designed to improve skin texture by introducing “Silky Fat”—a substance derived from the patient’s own fat—into the skin using the Dermapen 4.
Making Silky Fat from Your Own Fat
The NanoStem treatment offered at Bianca Clinic uses fat harvested from areas such as the abdomen and thighs.
Silky Fat is produced by further refining Condensed Rich Fat (CRF), which is obtained by removing unwanted components from harvested fat.
Silky Fat is a processed fat in a smooth consistency that contains fat-derived cellular components and growth factors. It is used not to add volume from the fat itself, but to improve skin firmness and texture.
Delivered into the superficial layers of the skin using the Dermapen 4
Silky Fat is introduced into the skin using a Dermapen 4, which features 16 ultra-fine needles. The Dermapen 4 creates microscopic holes, and the product is delivered evenly to the skin’s superficial layers through these channels.
This treatment aims to improve skin texture by combining the tissue repair response triggered by microneedling with the effects of the fat-derived ingredients in Silky Fat. In addition to the face, it can also be applied to the neck, décolletage, and the backs of the hands.
It serves a different purpose than fat grafting
The primary purpose of standard fat grafting is to add volume to fill in hollows or create a more three-dimensional appearance.
On the other hand, NanoStem focuses on improving skin texture and firmness. Therefore, it is not a procedure that significantly alters the shape of the face. During the consultation, in addition to assessing the condition of your skin, we will determine the areas from which fat can be harvested, the required amount, and the treatment area and depth.
▶If you'd like to learn more about the approach to treatments that involve fat extraction,Liposuction (LipoLife) PagePlease take a look at this as well.
What kind of results can I expect from NanoStem?
With NanoStem, improvements are expected for a variety of skin concerns, including skin firmness and radiance, fine lines, pores, and acne scars.
The main changes you can expect are as follows:
- Improves skin firmness, elasticity, and radiance
- Makes enlarged pores and fine lines less noticeable
- Smooths out acne scars and uneven skin texture
- Improves the overall texture of the skin, including dryness and dullness
The NanoStem treatment combines the tissue repair response induced by the Dermapen 4 with the effects of the stem cells, exosomes, and growth factors contained in Silky Fat. By supporting the production of components involved in skin structure—such as collagen—this treatment aims to improve skin firmness, elasticity, and smoothness.
Another key feature is its potential to address multiple concerns—such as pores, fine lines, and acne scars—all at once. However, it is not a procedure designed to physically lift deep wrinkles or large indentations.
If a lack of volume is the main cause, other options—such as fat grafting or hyaluronic acid injections—may be appropriate.
What are the pros and cons of NanoStem?
While NanoStem allows the use of autologous components, it is important to be aware of the burden of fat harvesting, post-treatment redness, and individual variations in results.
Benefits of NanoStem
- You can use your own fat
- Aim to improve skin texture without adding volume
- Addresses multiple skin concerns
- It can also be applied to areas other than the face
One advantage of using autologous tissue is that the risk of rejection is relatively lower compared to treatments that use tissue from other people or animals. However, this does not mean that “because it is autologous, there are absolutely no side effects.”
It is also an option for those who do not seek significant changes in volume, as with fat grafting, but rather wish to improve skin firmness and texture while maintaining a natural appearance.
Disadvantages and Precautions of NanoStem
- It is necessary to harvest fat from areas such as the abdomen and thighs.
- Redness, dryness, or a stinging sensation may occur in the treated area.
- Swelling, bruising, and pain may occur at the fat harvesting site.
- The way the effects manifest and how long they last vary from person to person.
NanoStem involves not only microneedling of the skin but also fat extraction. It’s important not to assume that “downtime is short” based solely on redness and dryness of the skin; instead, you should plan your schedule taking into account the recovery process for the fat extraction site as well.
Depending on your skin condition, body type, medical history, and other factors, this procedure may not be suitable for you. If you have any concerns about the post-procedure recovery process or the fat extraction itself, please discuss them with your doctor during your consultation.
Frequently Asked Questions
I’ll answer questions about the differences between NanoFat and other procedures, safety, treatments around the eyes, the recovery process at the fat harvest site, and how to choose a clinic.
Q. Are NanoStem and NanoFat the same thing?
A. They do not mean the same thing. “Nano Fat” is a general term for fat that has been finely processed. “Nano Stem” refers to a treatment that combines Silky Fat with the Dermapen 4.
Q. What is Silky Fat?
A. Silky Fat is a processed fat produced by removing unwanted components from fat harvested from the patient’s own body and then further refining and micro-processing it. It is derived from Condensed Rich Fat (CRF) that has been finely processed, and is characterized by fat particles that are finer than those in conventional nano-fat.
Q. Is the NanoStem procedure safe?
A. Although the risk of rejection is relatively low because autologous fat is used, this procedure is not without risks. Swelling, bruising, pain, redness, and hard lumps may occur as a result of fat harvesting and injection.
Q. Can I get the NanoStem treatment under my eyes as well?
A. Injections can also be administered around the eyes. However, the appropriate treatment for concerns under the eyes varies depending on the cause. Since NanoStem alone may not be able to improve all cases uniformly, we will determine your eligibility during a consultation.
Q. Does the NanoStem treatment cause any pain?
A. While the level of pain experienced during the procedure varies from person to person, we use intravenous anesthesia or sedation as needed, so you can undergo the procedure with minimal pain and anxiety. After the procedure, you may experience redness, a stinging sensation, or pain at the site where the sample was taken.
Instead of just adding volume, focus on your skin's condition. Consider NanoStem.
NanoStem is a treatment that uses Silky Fat—processed from your own fat—which is introduced into the skin using a Dermapen 4 to address skin concerns such as firmness, radiance, fine lines, and enlarged pores.
While this procedure aims to improve skin texture while maintaining a natural appearance, it is important to understand the physical strain involved in fat extraction, potential post-procedure symptoms, and the fact that results may vary from person to person.
At BIANCA CLINIC, we assess your skin condition and determine whether fat extraction is feasible, and we explore treatment options, including other procedures. If you’d like to know whether NanoStem is right for your concerns, please start by consulting with a doctor during a consultation.
▶Please take a look at the details of the NanoStem treatment.
▶Please contact us via the online reservation form.
