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2026.08.18
How Many Days Is the Downtime for Re2O? A Doctor Explains Symptoms, Recovery Process, and Post-Treatment Precautions
Engaged in both aspects of cosmetic dermatology and cosmetic surgery, he is an all-rounder doctor who pursues natural and elegant beauty with "the best interest of the patient" as his first priority. He is also a board-certified cosmetic surgeon by the Japanese Society of Aesthetic Plastic Surgery (JSAS). He specializes in hyaluronic acid injections, thread lifts, and facial surgery, and is a competent KOL (Key Opinion Leader) for ARTEMISLIFT and Hydro Rejuran. He is always sensitive to the latest trends and is always exploring knowledge and techniques.
After a Lituo treatment, you may experience temporary redness, swelling, or puffiness. If bruising occurs, it may take about 1 to 2 weeks to subside.
When considering Lituo (Re2O/Bunaju), many people are likely concerned about downtime—asking questions like, “How many days will the swelling last?” “Can I go to work the next day?” and “Will the bruising be noticeable?”
Since Lituo is a treatment that involves injecting a formulation into the skin, redness, swelling, puffiness, and bruising may occur after the procedure.
At BIANCA CLINIC, we believe it is important for patients to fully understand the post-treatment recovery process before deciding on treatment. Here, we explain the estimated downtime, the recovery process, and how to care for yourself after your procedure.
How long is the downtime for Lituo?
With Lituo, redness and mild swelling may last from a few hours to a few days. If bruising occurs, it may remain visible for about 1 to 2 weeks.
Estimated Downtime for Lituo
Rituo is a treatment in which a formulation consisting primarily of human acellular dermal matrix (hADM) is injected directly into the skin.
After the procedure, you may experience redness, swelling, or puffiness. Mild redness and swelling usually subside within a few hours to a few days, but if bruising occurs, it will gradually fade over the course of about 1 to 2 weeks.
It’s important to note that the length of downtime can vary depending on the treatment area, the extent of the procedure, your skin condition, and your individual constitution. If you have important plans coming up, it’s a good idea to schedule your treatment date with the possibility of bruising in mind.
Symptoms and Course of Recovery Common During the Downtime Following Lituo Treatment
After a Lituo treatment, you may experience redness, swelling, puffiness, or bruising. The severity and progression of these symptoms vary from person to person.
Common Symptoms Observed After a Rituo Treatment
After the procedure, common symptoms may occur, primarily as a result of the following injection treatments.
- redness
- Swelling and Edema
- bruising
- Pain or discomfort at the injection site
- Sensation of heat
- Itching
Immediately after the procedure, redness and swelling may be noticeable due to stimulation from the needles or cannulas. Additionally, if a blood vessel is affected during the injection, bruising may occur.
You cannot determine the effectiveness of treatment or whether an abnormality is present based solely on the nature of your symptoms. If you continue to experience any concerning symptoms, please consult the clinic where you received treatment.
Progress of Lituo's Downtime
Immediately after the procedure, you may notice redness, swelling, or puffiness at the injection site, but these symptoms will gradually become less noticeable over time.
If bruising occurs, it may last longer than the redness or swelling. Since it can take about 1 to 2 weeks to fade, we recommend allowing plenty of time in your schedule if you have a photo shoot or event coming up.
At Bianca Clinic, our doctors perform treatments while carefully assessing your skin condition to adjust the injection volume, depth, and target areas. Please feel free to consult with us about scheduling your treatment around your important plans.
The extent of downtime varies depending on the treatment area, the amount injected, and the condition of the skin.
At Bianca Clinic, our doctors administer injections by hand while carefully assessing each patient’s skin condition, adjusting the volume, depth, and injection site accordingly. We also use microcannulas to minimize the risk of pain and bruising during the procedure.
A Photo Series Showing the Progress of Lituo's Downtime
Here are some actual photos showing the progress after a Lituo treatment.
[Preoperative]
[Immediately After the Procedure]
[The Next Day]
[Day 3 After Surgery]
[Day 7 Post-Surgery]
*The before-and-after photos are for illustrative purposes only. The severity of redness, swelling, and puffiness, as well as the time it takes for these symptoms to subside, varies from person to person.
For photos showing the progress of downtime on the other days up to Day 7,Rituo (Bunaju) Treatment Pageis posted on [...].
How to Take Care of Yourself After a Rituo Treatment and Precautions to Keep in Mind
After a Lituo treatment, it is important to avoid strong stimulation of the injection site and to exercise caution regarding activities such as applying makeup, bathing, exercising, and drinking alcohol.
About Facial Cleansing and Makeup
You may apply makeup on the same day, as long as you avoid the treated area. Be careful not to rub the injection site too hard or touch it more than necessary.
Since precautions regarding facial cleansing may vary depending on the treatment area and your skin condition, please follow the post-treatment instructions.
About Showers and Baths
There are no restrictions on showering on the day of your treatment. You may take a bath starting the next day.
On the day of your treatment, we recommend that you avoid activities that cause your body to get very warm, such as taking long baths.
Daily Life, Including Exercise and Alcohol Consumption
On the day of your treatment, please avoid strenuous exercise, alcohol consumption, long baths, and vigorous massage of the treated area.
Side Effects and Risks of Rituo
With Lituo, there is a possibility of infection, allergic reactions, or inflammatory responses. Additionally, you cannot donate blood after the procedure.
Injection treatments involving Rituo may, in rare cases, cause infections, allergic reactions, or inflammatory responses.
In addition, because Lituo uses a preparation derived from human skin tissue, you will not be able to donate blood after the procedure. This is one of the important points you should be sure to understand before undergoing the procedure.
A doctor will determine whether you are eligible for treatment based not only on your skin concerns but also on your medical history, physical constitution, and current skin condition. If you have any concerns, such as a history of prior treatments or allergies, please let us know during your consultation.
If you'd like to learn more about Rituo's ingredients, how it works, and the benefits you can expect, please see “What Is Lituo Re2O (Bunaju)? An Easy-to-Understand Explanation of Its Expected Effects, Benefits, and Drawbacks"Please also see..."
Frequently Asked Questions About Lituo's Downtime
We’ll address common concerns you may have before your treatment—such as pain, bruising, the “hand-tapping” technique, and when you can expect to feel the effects of the Rituo treatment.
Q. Does the Rituo treatment hurt?
A. Since this is an injection treatment, you may feel some discomfort or pressure when the needle is inserted. The level of pain varies from person to person. At our clinic, we use topical anesthesia and very fine microcannulas with rounded tips to minimize any discomfort.
Q. When will I start to feel the effects of Rituo?
A. Lituo is not a treatment designed to produce immediate, dramatic changes in volume. Many people notice gradual changes in their skin texture over the course of several weeks, though the timing and extent of these changes vary from person to person.
Q. Can Lituo cause bruising?
A. Because this is an injection treatment that uses needles or cannulas, there is a possibility of bruising. If bruising occurs, it will gradually fade over the course of about 1 to 2 weeks.
Q. Is it okay to take Rituo right before an important event?
A. Since downtime varies from person to person, it’s best to avoid scheduling the procedure right before a planned event and to allow plenty of time when setting the appointment date. If you have an event or photo shoot coming up, please consult your doctor in advance.
Q. Is Rituo injected by hand?
A. At Bianca Clinic, our doctors administer injections by hand while carefully assessing each patient’s skin condition, adjusting the volume, depth, and injection site accordingly. If you have any questions about the procedure, please feel free to discuss them during your consultation.
Understand the downtime associated with Litou and create a treatment plan that’s right for you.
Re2O is an injection treatment designed to replenish the ECM components that form the foundation of the skin. After the procedure, redness, swelling, or puffiness may occur, and if bruising develops, it may take some time to subside.
It's important to develop a treatment plan that takes into account not only downtime but also your skin condition, the treatment area, and any important upcoming plans.
At BIANCA CLINIC, our doctors assess your skin condition before determining the appropriate treatment plan. If you have any concerns about the downtime associated with the Litwo treatment or your plans after the procedure, please feel free to discuss them with us during your consultation.
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