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“How much does Re2O cost?” “Why do clinic prices vary?” “Is it cheaper in South Korea?”—These are the kinds of questions many people have when considering Re2O (BNAJU), which is currently gaining attention as the next-generation ECM skin booster.

 

To put it simply, the price of Re2O is not determined solely by the cost of the product itself. In the field of cosmetic surgery, the final cost and results are determined by a comprehensive assessment of factors including the amount used, the injection technique, the surgeon’s skill, the consultation and treatment plan, and even aftercare.

 

In this article, from the perspective of a cosmetic surgeon, we will systematically explain market rates in Japan, price differences compared to South Korea, factors that influence cost-effectiveness, and how to make a wise choice.

 

• The domestic market price for Re2O (Rituo) is generally between 80,000 and 110,000 yen per full-face treatment.

• The main factors behind the price differences are “amount used,” “injection method,” and “the doctor’s fee.”

• In South Korea, the price per vial is generally around 500,000 to 650,000 won, but overall, Japan has the advantage.

• When choosing a cosmetic surgery clinic, base your decision on suitability assessment, the surgeon’s skill, and post-operative care rather than price.

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In addition, this article uses “Before & After” photos to highlight key points for evaluating the final results. Let’s move beyond focusing solely on price and work toward making the quality of care provided by cosmetic surgery clinics more transparent.

Re2O (Rituo) Average Rates and Price Estimates

In Japan, the typical cost for a single full-face treatment with Re2O (Rituo / hADM formulation) is generally around 80,000 to 110,000 yen.

 

While the apparent price may vary depending on the treatment plan, whether multiple treatments are combined on the same day, and the availability of promotions, as a cosmetic surgery clinic, we must make our assessment by taking into account the “appropriate dosage,” “injection plan tailored to the patient’s goals,” and “comprehensive aftercare.”

• 1 session (full face): Approximately 80,000–110,000 yen

• 3-Session Course: Approximately 180,000–300,000 yen

• Items that often incur additional charges: topical anesthetic, needles and cannulas, follow-up visit fees, and skincare

For example, some cosmetic surgery clinics display transparent pricing, such as “110,000 yen per session, 297,000 yen for three sessions (tax included); topical anesthesia is charged separately.”

 

It is important to note that even if the treatment is described as a single “session,” the actual dose can vary depending on factors such as “density of treatment across the entire face,” “whether additional treatment is applied to the neck or around the eyes,” and “the number of vials used.” Ask the provider to clearly specify the “dose (mL),” “treatment areas,” and “anesthesia and supplies” on the estimate to ensure transparency in the breakdown of Re2O’s pricing.

When checking promotional prices at cosmetic surgery clinics, be sure to review the “terms and conditions”

While these promotions may seem like a good deal, they often come with restrictions—such as limited treatment areas—or conditions like “small trial amounts” or “same-day add-on required.” If before-and-after photos are provided, it’s reassuring to be able to verify when they were taken (which session and how many days later), whether the lighting and angles are consistent, and whether any skincare products or additional treatments were used.

 

When choosing a cosmetic surgery clinic, compare them based not only on photos but also on the quality of their treatment process.

Why Do Prices Vary Between Clinics? An Analysis from a Cosmetic Surgery Perspective

① The amount used varies—the right amount offers the best value for your money

With Re2O, the key is “how thinly and widely it is applied, to which layers, and at what density.” The required amount varies depending on the treatment—such as spot treatment, full face, full face plus neck, or additional treatment around the eyes—and as the number of vials used increases, so does the cost.

 

In cosmetic surgery, we evaluate skin thickness, the degree of atrophy, and the distribution of pores and fine lines through visual and tactile examination, and then determine the optimal dosage for each layer. It is a sign of integrity if the estimate lists not only the total volume in mL but also the breakdown by area (e.g., cheeks 2 mL, forehead 1 mL, around the eyes 0.5 mL, etc.).

② Different delivery methods—manual injection / hydrafacial / Potenza treatment / MiraJet

Hand-injection excels at intricate designs and allows for meticulous layer planning that takes into account skin texture, wrinkle direction, and the course of ligaments; however, it requires time and skill, which tends to drive up the cost of the procedure. On the other hand, hydrafacial treatments can treat large areas uniformly and are often chosen for their minimal downtime and shorter procedure time.

 

The use of Potenza or MiraJet is often considered as an option to minimize the sensation of needle insertion. In cosmetic surgery, it is not uncommon to combine different methods after carefully evaluating the patient’s concerns, skin condition, and the characteristics of the device.

③ Physicians“ Technical Fees and Organizational Structure—Reflecting the ”Quality of Care” in Cosmetic Surgery

Re2O is not a product that can simply be injected. Anatomical considerations—such as skin thickness, the condition of the dermis, the direction of wrinkles, the arrangement of ligaments and fat, and the course of blood vessels—are essential.

 

Furthermore, the cost reflects explanations and treatment for bruising, swelling, and rare allergic reactions, as well as our aftercare system (contact information, follow-up visits, and guidance on topical treatments). As a cosmetic surgery clinic, our commitment to making sound judgments—such as refraining from performing procedures outside our scope of practice—and our integrity in avoiding excessive dilution are also factors that go “behind the price.”

Price Comparison Between South Korea and Japan—Total Cost of Cosmetic Surgery

In South Korea, the approximate cost is 500,000 to 650,000 won per vial of Re2O, though some facilities charge VAT separately. When comparing prices, don’t just look at the listed price—be sure to factor in the total cost, including the items listed below.

• Travel Expenses, Lodging Expenses, and Interpretation Fees

• Initial Visit, Follow-up Visit, and Retouch Fees; VAT

• The Burden of Relocation and the Cost of Business Interruption During Downtime

• Availability of Support for Corrections or Troubleshooting in Case of Emergencies

When considering ongoing treatment (3 initial sessions, followed by maintenance every six months to a year), the advantage of being able to visit the same cosmetic surgery clinic in your neighborhood is significant, and it is not uncommon for Japan to offer a better deal in terms of total cost and peace of mind.

 

The cost of Re2O should be evaluated based on its “actual cost”—which includes not only a comparison of unit prices but also post-operative care and follow-up.

How Many Times? At What Intervals? Treatment Plans Recommended by Cosmetic Surgeons

The general recommendation is “three initial sessions at one-month intervals,” followed by “maintenance every 6 to 12 months.” While some patients notice improved radiance and hydration after just one session, multiple sessions are recommended if the goal is to optimize the ECM environment and promote collagen remodeling using hADM (human-derived acellular dermal matrix). In cosmetic surgery, the treatment depth and density are customized based on factors such as whether the focus is on pores and fine lines or on redness and loss of firmness, as well as the underlying inflammatory conditions in the epidermis and superficial dermis. At home, continue using topical treatments such as retinol and niacinamide, practice sun protection, and maintain adequate hydration to lay the foundation for the treatment’s effectiveness.

Is Lituo Expensive? — A Cosmetic Surgery Approach to Maximizing Cost-Effectiveness

6 Factors That Determine Cost-Effectiveness

• Determining the Right Treatment (Volume restoration with hyaluronic acid, etc.; skin texture and underlying structure improvement with Re2O)

• Selecting an Injection Method (Optimizing the Combination of Manual and Device-Assisted Injection): Is the solution dissolved in saline or in a skin-nourishing agent such as Hydro?

• Ensuring the Required Quantity (“Appropriate Quantity × Design” Rather Than “Small Quantities at Low Cost × Frequent Purchases”)

• Designing Combination Treatments (e.g., laser for redness, microneedle RF for skin texture, etc.)

• Aftercare (Moisturizing, Soothing, Lifestyle Guidance)

• Continuity (Financial plan based on an initial 3 sessions plus ongoing maintenance)

A carefully tailored program based on the above principles yields higher satisfaction than a one-time, low-cost plan and leads to long-term youthful appearance. The “design expertise” of our cosmetic surgery clinic delivers value that exceeds the price of Re2O.

Price Comparison with Other Skin Boosters

As a general guide, the prices are approximately 50,000 to 80,000 yen for Rejuran, 60,000 to 90,000 yen for Jubelook, 90,000 to 130,000 yen for Profhilo, and 80,000 to 110,000 yen for Rituo. While the prices aren’t exceptionally high, the indications and mechanisms of action vary by product.

 

At our cosmetic surgery clinic, we take into account your “priorities regarding your concerns” as well as “seasons and life events” to create a realistic annual treatment plan.

A Checklist for Choosing a Cosmetic Surgery Clinic and How to Interpret "Before & After" Photos

• Is there clear information regarding standard formulations, lot control, and storage procedures?

• Does the estimate clearly specify the dosage (mL), distribution by body part, anesthesia, and supplies?

• Is information disclosed regarding the practitioner (who performs the injection), their years of experience, and their areas of expertise?

• Selection of Needles and Cannulas, Measures to Prevent Pain and Bruising, and Standards for Aseptic Technique

• Is an aftercare system (contact information, follow-up visits, guidance on topical treatments, and emergency response) in place?

• Check for excessive dilution or unnatural “discount” terms

• Do the "Before & After" images include information on the shooting conditions, timing, number of sessions, and any additional treatments used?

"Before & After" images can give a different impression depending on the light source, camera angle, facial expression, and whether or not makeup is worn. In cosmetic surgery, we place great importance on standardizing medical photography (using the same conditions and the same distance) to ensure evaluations are free from subjective bias.

Frequently Asked Questions (Answered by a Cosmetic Surgeon)

Q. Is Re2O covered by insurance?

This is a cosmetic procedure paid for out-of-pocket. It is not covered by public health insurance. Prices at cosmetic surgery clinics are set within the scope of private medical care and may vary depending on the amount used, the method, and the facility’s policies.

Q. Is the cost of anesthesia included in the fee?

This varies by facility. Surface anesthesia, nerve block anesthesia, cooling, and the cost of needles and cannulas may be billed separately. Be sure to check the breakdown on the estimate and compare the total costs among cosmetic surgery clinics.

Q. Is there any effect even after just one session?

You may notice improved radiance and hydration after just one session. However, structural changes—such as firmness, elasticity, and pore appearance—typically require multiple sessions to achieve visible results. At our cosmetic surgery clinic, we generally recommend a plan consisting of three initial sessions.

Q. What about downtime and risks?

Redness, swelling, pinpoint bleeding, and mild pain usually subside within a few days. In rare cases, reactive swelling or acne-like changes may occur; if necessary, anti-inflammatory and soothing treatments will be provided. If you notice any abnormalities, contact the cosmetic surgery clinic as soon as possible and follow the post-operative instructions (face washing, bathing, sun protection, and topical treatments).

Q. Is it cheaper in South Korea?

At first glance, the per-procedure cost may seem low. However, when you factor in travel expenses, interpretation fees, VAT, follow-up visits, and the time and effort required to resolve any issues, it is often more beneficial overall to continue receiving treatment at a cosmetic surgery clinic in Japan.

Don't Be Misled by Re2O's Price—Choose Based on the "Quality of the Cosmetic Surgery Clinic"

The average price for a full-face Re2O (Rituo) treatment in Japan is approximately 80,000 to 110,000 yen per session. While this may seem expensive at first glance, considering its approach to optimizing the “foundation of the skin” through hADM-derived ECM, it is a treatment that is highly effective in addressing a wide range of skin concerns (firmness, fine lines, pores, redness, and skin texture).

 

There are clear reasons behind the price differences, including “volume used,” “injection method,” “physician’s fee,” and “aftercare.” The more you understand these factors, the more you’ll realize that even when the price of Re2O is the same, the results can vary significantly. At our clinic, we dissolve Lituo (BNAJU) in HYDRO to enhance its effectiveness, so the price includes the cost of this formulation.

 

When choosing a cosmetic surgery clinic, prioritize the use of approved medical products, transparent cost breakdowns, the surgeon’s expertise, standardized “Before & After” photos, and thorough follow-up care. Investing in the “big picture”—focusing on design and long-term results—rather than just the “short-term” appeal of low prices will lead to satisfaction in the shortest possible time.

 

If you're unsure, start by visiting a cosmetic surgery clinic for a skin assessment and suitability evaluation, and have them create a plan tailored to your skin condition—including the optimal number of sessions, dosage, and treatment method.

Summary

The cost of Re2O (Rituo) varies significantly depending not only on the formulation itself but also on the dosage, dilution method, injection technique, and aftercare.

 

While there may be differences in treatment costs between South Korea and Japan, it is important to consider the overall cost-effectiveness, including ongoing treatment and support in the event of any complications.

 

Rather than choosing a clinic based solely on price, it’s important to visit a cosmetic surgery clinic that uses approved medical products, offers appropriate treatment plans, ensures safety, and provides thorough post-operative follow-up—and to have them propose a plan tailored to your skin condition. This approach will lead to long-term satisfaction.

 

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