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2026.06.12
What Is ezGEL? BIANCA CLINIC Explains This Popular Filler Made from Your Own Blood
Driven by the belief of “bringing happiness to more people,” I pursued a career in aesthetic medicine after gaining experience in general internal medicine and emergency surgery, along with overseas training. As an internationally oriented doctor holding a UN English Proficiency Test Special Grade A, I treat a diverse range of patients. My goal is to become a true all-rounder, spanning cosmetic surgery, cosmetic medicine, and cosmetic dermatology. With a deep understanding of global beauty standards, I serve as a Key Opinion Leader (KOL) for TargetCool, NEAUVIA®, and CORETOX®. Known for my gentle manner, I provide accessible consultations in both Japanese and English. I pursue aesthetic medicine that transforms not just appearance, but also enhances overall happiness.
Hello! This is Bianca Clinic.
In the aesthetic medicine industry, anti-aging treatments that incorporate the principles of regenerative medicine are currently gaining attention. Among these, one approach that has been attracting significant attention in Europe and the United States in recent years is"ezGEL"is.
"EasyGel" is an autologous preparation made from the patient's own blood and is viewed as a promising form of "aesthetic medicine that harnesses the body's own healing power."
Although it hasn’t yet become widely popular in Japan, this is one treatment that is likely to gain more attention in the future. In this article, I’ll explain—from a doctor’s perspective—what the “EasyGel” procedure entails, how it works to produce results, and how it differs from hyaluronic acid injections.
What is “ezGEL”?
"ezGEL" refers to an autologous gel-based preparation manufactured using the patient's own blood. Here, we explain the basic information about "ezGEL" and the reasons behind its growing attention.
A New Formulation with the Potential to Realize the Western Trend of “Bioidentical Beauty”
One of the recent trends in cosmetic medicine in Europe and the United States is the concept of “bioidentical” treatments. This approach focuses on bringing out a natural, youthful appearance by concentrating and utilizing “substances found in one’s own body” as much as possible, rather than injecting artificial synthetic ingredients or chemicals into the body.
As a next-generation filler that epitomizes this trend, “EasyGel” is attracting attention from discerning aesthetic medicine users and doctors in Europe and the United States.
What is the blood-derived ingredient that forms the basis of “ezGEL”?
"ezPRF" serves as the foundation for ezGEL. “PRF (Platelet-Rich Fibrin)” is an additive-free blood concentrate obtained by low-speed centrifugation of the patient’s own blood; it is rich in platelets, white blood cells, and growth factors. It is an advanced version of “PRP,” which has long been used in the fields of aesthetic medicine and regenerative medicine.
"ezPRF" is an autologous blood-derived product for "EasyGel" manufactured based on the "PRF" concept. "EasyGel" is a blood-derived product that represents a further evolution of "ezPRF."
The Effects of “ezGEL” as Demonstrated in the Research Paper
A multicenter clinical study published in 2025 reported that, in 25 patients with moderate to severe nasolabial folds who received injections of ezPRF and EasyGel, the depth of the nasolabial folds improved by up to 50% after one month, and the improvement was maintained even after six months*.
Side effects are limited to bruising and mild swelling, and are temporary in all patients. It is believed that these lead to lasting improvements because growth factors are released gradually to restore volume.
*(References) Multi-Center Clinical Study of EZPRF and EZGEL for the Correction of Nasolabial Folds
How "ezGEL" Works and Why It's Gaining Attention
In this section, we’ll explain the process behind the development of “ezGEL,” its standing in Europe and the United States, and why Bianca Clinic is taking notice of it.
How Is “ezGEL” Made?
The manufacturing process for “ezGEL” is carried out on a made-to-order basis using dedicated equipment within the clinic after the patient arrives.
〈The Process of Creating ezGEL〉
- Drawing Blood
First, we draw about 10 to 20 ml of the patient’s own blood. - Perform centrifugation
The blood is centrifuged using specialized equipment to separate it into ezPRF and plasma. - Heat the plasma
Heat the separated plasma to 75°C. - Gelify
When heated, human serum albumin in the blood denatures and forms a gel-like structure. - Mix with PRF
Mix the gelified ingredients with ezPRF to create “ezGEL.”
Heating to 75°C is the key!
In the manufacturing of “ezGEL,” a temperature of 75°C plays a crucial role. Human serum albumin, which is present in blood, undergoes a structural change at this temperature and forms a natural gel.
This makes it possible to create gel-like fillers without using chemical cross-linking agents, as is the case with hyaluronic acid preparations.
The Positioning of "ezGEL" in Europe and the United States
Conventional hyaluronic acid fillers are widely used around the world. However, among some medical professionals in Europe and the United States, there is ongoing debate regarding “cross-linking agents”—substances used to maintain the formulation’s structure—and whether trace amounts of them remain in the body over the long term.
On the other hand, since “ezGEL” is made from components derived from the patient’s own blood, it is viewed in Europe and the United States as “a more natural filler option.”
Furthermore, as a procedure that combines volume restoration with the use of the body’s own tissue—much like “fat grafting”—it is attracting increasing interest in Europe and the United States. It is drawing particular attention as a potential new option, especially for individuals with low natural fat reserves or those seeking treatment with minimal physical strain.
Why BIANCA CLINIC Adopted ezGEL
At Bianca Clinic, we place great importance on listening to each patient’s concerns and wishes and offering a wide range of treatment options. Guided by the philosophy of fostering health and beauty from the inside out—rather than focusing solely on outward appearance—we are actively engaged in various fields of aesthetic medicine and regenerative medicine.
Based on this philosophy, Bianca Clinic is now offering EasyGel treatments. EasyGel is a procedure that uses an autologous preparation derived from the patient’s own blood. We recommend it as one of the treatment options for restoring volume to areas such as nasolabial folds and sunken cheeks.
If you are interested in EasyGel, please feel free to contact us for a consultation. Through an examination and consultation, we will propose a treatment plan tailored to your concerns and preferences.
Frequently Asked Questions
What is the difference between ezGEL injections and PRP injections?
PRP injections are a procedure in which “platelet-rich plasma (PRP)”—a concentrated blood product obtained by centrifuging the patient’s own blood—is injected into areas of concern on the skin, with the aim of improving skin firmness and other benefits. In contrast, ezGEL injections involve injecting a formulation in which the blood concentrate has been heated to gelify it. Because it takes on a gel-like consistency, it is considered better suited for volume restoration than PRP injections.
Is ezGEL made entirely from your own blood?
ezGEL is an autologous preparation made from the patient's own blood. No chemical cross-linking agents or additives are used in the manufacturing process.
Can ezGEL be used as a substitute for hyaluronic acid?
It depends on the purpose. Both hyaluronic acid and ezGEL are sometimes used to restore volume in areas such as nasolabial folds and sunken cheeks. However, because they contain different ingredients and have different characteristics, they are not exactly the same. It is important to choose the appropriate treatment based on your concerns, preferences, and the treatment area.
Does ezGEL (Easy Gel) cause allergic reactions in anyone?
Since it is made exclusively from the patient’s own tissue, the risk of rejection reactions or severe allergic reactions—such as those associated with artificial materials—is, in theory, extremely low. However, since heating the plasma separated from blood causes a slight change in the properties of a protein called “human serum albumin (HSA),” the possibility of an immune reaction occurring in extremely rare cases, depending on the patient’s constitution, cannot be completely ruled out.
When providing injection treatments using ezGEL, our doctors will carefully review your medical history—including any history of allergies—during a preliminary consultation.
What should I do if I'm interested in ezGEL?
If you are interested in ezGEL, please contact Bianca Clinic for a consultation. Since ezGEL is made using the patient’s own blood, a preliminary examination is required to determine suitability and the specifics of the procedure. At Bianca Clinic, we listen to your concerns and wishes and then propose treatment options, including ezGEL.
"ezGEL" is a new option for improving your skin from the foundation up
"ezGEL" is an autologous gel formulation made from a patient's own blood. Against the backdrop of growing interest in "bioidentical beauty" and regenerative medicine in Europe and the United States, it is attracting attention and is expected to become a popular option among those seeking premium aesthetic medical treatments.
At Bianca Clinic, we constantly keep in mind the question, “What will best enhance our patients’ beauty?” and stay up to date on the latest information from both Japan and abroad. We strive to acquire knowledge and techniques in the latest cosmetic medical treatments to support our patients’ healthy beauty and youthful appearance. If you’d like to learn more about “Easy Gel” or find out which anti-aging treatments are right for you, please feel free to schedule a consultation.
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