column (e.g. in newspaper)
2026.08.29
What Is JOURNAVX™? An Explanation of This Non-Opioid Analgesic Gaining Attention for Postoperative Pain Management in Aesthetic Medicine
He is also a leader outside of the clinic, serving as president of Creation Labo, producer of cutting edge, and board member of the Japanese Society of Cosmetic Internal Medicine. She is also active as a leader outside the clinic, serving as the president of Creation Labo, producer of Cutting Edge, and board member of the Japanese Society of Aesthetic Internal Medicine. She aims to go beyond satisfaction to inspiration. He is a game changer in the world of aesthetic medicine, proposing Lifestyle Beauty that transcends the boundaries of aesthetic medicine.
In cosmetic medicine, it is important to consider not only the final results but also the experience during and after the procedure. The invasiveness and pain associated with surgery can be stressful for the body and may trigger a stress response involving hormones such as cortisol.
こうしたなか、術後疼痛管理の新たな選択肢として注目されているのがJOURNAVX™（ジャーナバックス）です。BIANCA CLINIC（ビアンカクリニック）の医師の視点から、その特徴を簡潔に解説します。
What kind of medication is Journalax?
JOURNAVX™（ジャーナバックス）は、末梢神経のNaV1.8というナトリウムチャネルを標的として痛みの信号伝達を抑える非オピオイド鎮痛薬です。
JOURNAVX™（ジャーナバックス）は一般名をスゼトリギン（suzetrigine）といい、成人の中等度から重度の急性疼痛を対象として、2025年1月に米国FDAの承認を受けました。
Its distinctive feature is that it selectively inhibits the NaV1.8 sodium channel, which is expressed in peripheral sensory neurons. It acts on pain signal transmission through a pathway different from that of opioids.
It is also being studied in the context of postoperative pain management in cosmetic surgery.
Clinical research is also underway on the use of Jarnavax for pain management following cosmetic and plastic surgery.
2026年に公表されたPhase 4試験*では、美容・再建外科手術を受けた99人に、JOURNAVX™（ジャーナバックス）を含む複数の鎮痛方法を組み合わせた疼痛管理が行われました。その結果、90.9％が治療期間終了までレスキューのオピオイドを使用しなかったと報告されています。
However, based on this study alone, it cannot be conclusively stated that “using Jarvax eliminates the need for opioids.” This is because the study did not directly compare Jarvax with other treatments. Further research is needed to confirm its effectiveness and proper usage.
*Phase 4 trials… Trials conducted after the product has been released (after it has gone on the market)
Reference Materials
The Relationship Between Pain, Stress, and Cortisol
Surgical stress can trigger the body's stress response, and depending on the degree of stress, cortisol levels may rise.
手術は身体にとってストレスの一つです。71研究・2,953人を対象としたシステマティックレビュー*では、身体への負担が大きい手術ほど、手術前後のコルチゾール上昇が大きい傾向が報告されています。
While research has examined the links between chronic stress and cortisol and health and aging, it has not been confirmed that pain following cosmetic surgery directly “accelerates aging.” Furthermore, there is no evidence that Jarnavax has anti-aging effects.
Since these treatments are intended to enhance your beauty, it’s important to consider not only the results but also any pain or physical strain they may cause.
*システマティックレビュー…複数の研究結果をまとめて評価する研究手法
ジャーナバックスについて知っておきたい注意点
JOURNAVX™（ジャーナバックス）には薬物相互作用や副作用があり、日本国内では未承認薬として慎重な取り扱いが必要です。
米国FDAの添付文書では、主な副作用としてかゆみ、筋けいれん、CK（クレアチンホスホキナーゼ）上昇、発疹などが挙げられています。重篤な副作用は報告されておらず、吐き気や嘔吐は比較的低い傾向が示されています。
また、一部のCYP3A阻害薬との併用やグレープフルーツの摂取にも注意が必要です。
JOURNAVX™（ジャーナバックス）は米国では承認されていますが、日本国内では未承認とされています。
Frequently Asked Questions
Q. How does BIANCA CLINIC manage pain after cosmetic surgery?
A. At BIANCA CLINIC, we determine the appropriate approach to pain management based on the specific procedure and the patient’s post-operative condition. We offer several options for anesthetics used during surgery. We also prescribe pain medication after surgery; however, the method of administration varies depending on the patient’s condition, so please consult your doctor during your consultation for more details.
Q.ジャーナバックはオピオイド鎮痛薬と何が違いますか？
A. JOURNAVX™（ジャーナバックス）は、末梢神経のNaV1.8 というナトリウムチャネルを選択的に阻害する非オピオイド鎮痛薬です。オピオイド受容体を標的とせず、異なる仕組みで急性疼痛に作用します。
Q. ジャーナバックは美容外科の手術後の痛みにも使われていますか？
A. In the United States, it has been evaluated in clinical trials involving acute postoperative pain, such as that associated with abdominoplasty, and research is progressing regarding its use in postoperative pain management in the field of cosmetic and plastic surgery. However, it is not approved in Japan, so its use in Japan must be considered separately.
Cosmetic Medicine That Takes Post-Surgery Pain Into Account
JOURNAVX™（ジャーナバックス）は、オピオイドとは異なる仕組みで急性疼痛に作用する新しいタイプの鎮痛薬です。美容外科領域でも研究が始まっており、今後の術後疼痛管理を考えるうえで注目される選択肢の一つです。
At the same time, it is essential to understand not only the characteristics of medications but also their safety, potential interactions, and approval status in Japan. At BIANCA CLINIC, we provide information on the latest findings in aesthetic medicine while verifying the underlying medical evidence.
