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When you hear the term “before and after” in relation to NMN IV therapy, you might imagine changes such as dramatic improvements in skin firmness and radiance, increased stamina, and a more youthful appearance.

 

However, NMN IV therapy, unlike hyaluronic acid injections or laser treatments,This is not a cosmetic procedure where it is easy to clearly compare results based solely on before-and-after photos.

 

NMN (nicotinamide mononucleotide) is a precursor used by the body to synthesize NAD⁺ (nicotinamide adenine dinucleotide). NAD⁺ is involved in various biological reactions, including cellular energy metabolism.

 

NAD⁺ precursors, including NMN, are being studied in the field of anti-aging, but even in reviews from 2025 to 2026,The anti-aging effects in humans have not yet been established.

 

In addition, many of the current human clinical studies focus on oral NMN, andClinical data on NMN infusions themselves is very limited.

 

In the 2026 systematic review as well, only one study on intravenous NMN met the inclusion criteria, and it primarily evaluated short-term safety and biomarkers.

 

Therefore, based on current medical evidence, it is not possible to make claims such as “A single NMN IV drip will rejuvenate your skin” or “How many treatments are needed to look 10 years younger?”

 

As a cosmetic medicine physician, what I value most is,Choose your anti-aging routine based not only on the impression given by before-and-after photos, but also on an understanding of what is currently known—and what is not yet known—about NMN.is.

 

In this article, under the theme “NMN IV Therapy: Before and After,” I will provide a detailed explanation from the perspective of a cosmetic internal medicine physician, covering what changes can be expected from NMN IV therapy, when you might start to notice results, its effects on the skin, how long those effects last, and important considerations when evaluating this treatment.

What Is an NMN IV Drip? — A Simple Guide to the Basics

NMN (nicotinamide mononucleotide) is a substance used in the body as a building block for the coenzyme NAD⁺.

 

NAD⁺ plays a role in energy metabolism, DNA repair, and cellular signaling. An IV drip is a method of administering NMN intravenously; unlike oral supplements, it bypasses the digestive tract.

 

However, it cannot be conclusively stated at this time that “intravenous administration is more effective.” Most studies have been conducted using oral administration, and clinical data on intravenous administration are limited.

How to Interpret NMN IV Drip Before-and-After Results: Evaluation Criteria That Go Beyond Just Photos

NMN IV therapy differs in nature from procedures such as hyaluronic acid injections and Botox, which directly target the shape of the face and the movement of facial muscles.

 

For this reason, it is not appropriate to determine whether a treatment “worked” or “didn’t work” based solely on “before and after” photos. When evaluating results, we should combine the following indicators, taking into account both external and internal aspects.

• Skin: Moisture levels, elasticity, texture (objective measurements from a cosmetic dermatology clinic can serve as a reference)

• Physical Condition: Fatigue, Sleep Quality, Energy Levels During the Day

• Metabolism: Body weight, body fat percentage, and test results for blood glucose, lipids, etc.

These factors are also influenced by daily sleep, diet, UV exposure, stress, and other cosmetic procedures. Therefore, one cannot conclusively determine the effectiveness of NMN based solely on the “Before & After” results.

Changes and Limitations of the Skin—From the Perspective of Cosmetic Dermatology

While basic research has reported findings regarding ultraviolet rays and collagen, there is still limited clinical data in humans to substantiate claims such as “a X% improvement in wrinkles.”

 

In cosmetic dermatology, we specialize in direct treatments such as lasers, radiofrequency (RF), and Botox for age spots, wrinkles, and sagging skin.

 

It’s best to view NMN IV therapy as a treatment that “may indirectly affect the skin’s foundation.”

Fatigue, Energy, and Sleep: Do You Notice Any Effects?

While some people report subjective changes, such as “I feel lighter the next morning,” we have not yet reached the stage where objective data can demonstrate a consistent effect.

 

Energy levels and sleep are significantly influenced by bedtime, caffeine, alcohol consumption, exercise levels, and mental state, so these factors cannot always be explained by NMN infusions alone.

 

When recording "before and after" data, it is easier to make assessments if you also use a sleep diary, activity tracking, and a simple quality of life (QOL) score.

Metabolism and Weight: This Is Different from "Before & After" Photos of Liposuction

The question, “Can I lose weight with NMN IV drips?” requires a careful explanation.

 

At this point, its role as a weight-loss treatment has not been established. Liposuction performed in cosmetic surgery is a surgical procedure that directly alters body contours and volume, making it an area where “before and after” results are easily visible.

 

NMN IV therapy is a complementary approach that comprehensively assesses metabolic markers and overall health; it is not a substitute for liposuction.

 

Since the purposes differ, let’s choose based on “what you want to change” rather than comparing which is better or worse.

Is Rejuvenation Really Possible?—The Current State of Clinical Evidence

While there have been promising reports in preclinical studies, reviews continue to indicate that the effects in humans are inconsistent. At this stage, we should avoid making definitive claims such as “one treatment makes you look 10 years younger.”

 

Compared to cosmetic surgery procedures—such as breast augmentation, liposuction, and Botox—that produce clearly defined results, the “before and after” effects of NMN IV therapy must be evaluated by taking into account a combination of biological markers and subjective changes.

How Many Times? When Will You Start to Feel the Effects? — How to Think About Frequency and Timing

There is no established standard number of times or guideline stating that "changes will definitely occur after X days."

 

The frequency and duration of treatment will be determined on an individual basis, taking into account age, physical condition, treatment goals, and any concurrent therapies (e.g., skin treatments at a cosmetic dermatology clinic, Botox for expression lines, and post-surgical care following cosmetic surgery).

 

Individual experiences vary, and even with the same dosage, the intensity of the effects differs from person to person.

Things to Keep in Mind When Looking at "Before & After" Photos

The overall impression can vary depending on lighting, angle, facial expressions, makeup, camera settings, skin hydration, and image editing. Furthermore, if you undergo treatments such as Botox, laser therapy, or chemical peels around the same time, it becomes difficult to determine exactly which treatment contributed to the results and to what extent.

 

Standardizing photography conditions at cosmetic dermatology and cosmetic internal medicine clinics—and, if possible, setting aside a period dedicated solely to NMN IV therapy—will improve the accuracy of “before and after” assessments.

Positioning NMN IV Therapy in Combination with Other Treatments

Overall Design for Aesthetic Internal Medicine

In our aesthetic medicine department, we focus on establishing a solid foundation—including sleep, nutrition, exercise, body composition, blood sugar and lipid levels, UV protection, and stress management—while incorporating NMN IV therapy as needed.

 

The strength of cosmetic internal medicine lies in “bridging the gap between physical health and beauty.” For example, we adjust treatment plans by evaluating daytime energy levels, sleep quality, skin analysis, and blood test results all on the same plane.

Differences in Roles Compared to Cosmetic Surgery Procedures (Liposuction and Breast Augmentation)

Cosmetic surgery procedures such as liposuction and breast augmentation are surgical solutions that directly alter body contours and are known for producing visible "before and after" results.

 

On the other hand, NMN IV therapy is not a procedure that alters facial contours.

 

Some people consider cosmetic internal medicine or NMN IV therapy as a way to lay the groundwork for managing their health and recovery before and after cosmetic surgery; however, NMN cannot replace or enhance the results of procedures such as liposuction or breast augmentation. It’s important to clearly define your goals and expectations.

Considerations for Combining with Aesthetic Dermatology Treatments (such as Botox)

Treatments offered at cosmetic dermatology clinics—such as Botox, hyaluronic acid, light and laser therapies, RF, HIFU, and chemical peels—vary in terms of their immediate effects and duration depending on their intended purpose.

 

Botox directly targets expression lines, while lasers directly target skin tone and texture.

 

While NMN IV therapy is positioned as a form of “whole-body care” that can be administered alongside these other treatments, using them simultaneously makes it difficult to distinguish between “before” and “after” results.

 

It is helpful to organize your treatment plan so that the evaluation period for Botox (ranging from several weeks to several months) does not overlap too much with the evaluation period for NMN infusions.

Checklist for Consultations in Ginza, Tokyo

• Choose whether to consult a cosmetic medicine, cosmetic surgery, or cosmetic dermatology clinic based on your goals (there are plenty of clinics specializing in each of these fields in Ginza, Tokyo).

• Does the clinic offer consultations with a doctor, and do they thoroughly review your medical history and current medications? (A thorough initial evaluation is essential in aesthetic medicine.)

• Does it avoid making definitive claims about the effects and also explain the limitations and risks of NMN IV therapy?

• Does it provide an unbiased explanation of how Botox, liposuction, breast augmentation, and other procedures differ in their roles?

• Does the clinic in the Ginza area of Tokyo offer convenient access, emergency care, and a hygienic environment?

In addition to geographical convenience, prioritize the sincerity of the explanation and safety precautions. Precisely because there are so many options in Tokyo and Ginza, it’s important to compare and evaluate them carefully.

Safety and Risks: Key Points to Know

There is not yet sufficient long-term, large-scale human safety data on NMN infusions.

 

As with any intravenous treatment, there is a possibility of pain, redness, bruising, vascular pain, malaise, allergic reactions, and infection at the injection site.

 

If you are pregnant or breastfeeding, have severe liver or kidney dysfunction, are currently undergoing or have a history of cancer treatment, have a history of severe allergies, or are taking multiple medications, please consult individually with a cosmetic medicine specialist or your primary care physician.

 

We are not yet at the stage where we can definitively say whether or not there is a cancer risk.

Frequently Asked Questions (FAQ)

Q1. Can you see a "before and after" difference after just one NMN infusion?

Results vary greatly from person to person, and there are no standard data points that allow us to definitively determine whether a clear change has occurred after just one session. Don’t base your judgment solely on photos; instead, track your progress using metrics that align with your goals.

Q2. Does it help rejuvenate the skin?

While there is basic research on the skin, evidence quantitatively demonstrating cosmetic benefits in humans is limited. Its role differs from that of cosmetic dermatology procedures (e.g., Botox and laser treatments).

Q3. Should I get this treatment for weight loss?

There is no established scientific basis for this as a weight-loss treatment. If your goal is to change your body contour, you should consider options such as liposuction at a cosmetic surgery clinic, depending on your specific goals.

Q4. Can this treatment be combined with other treatments?

Depending on your physical condition and the specifics of the treatment, these procedures may be performed together; however, if they are done at the same time as Botox or laser treatments, it becomes difficult to determine the “before and after” results. It’s safest to schedule them separately.

Q5. Where can I go for a consultation in Ginza, Tokyo?

Please compare and evaluate these options based on which—cosmetic internal medicine, cosmetic surgery, or cosmetic dermatology—best suits your needs, while prioritizing the honesty of the explanations provided and the safety measures in place.

How to Conduct a Consultation (General Guidelines)

• Clarifying Your Goals: Identify what you want to improve—such as your skin, overall health, or metabolism

• Initial Assessment: Medical History, Prescription Medications, Sleep, Nutrition, and Exercise; Tests as Needed

• Planning: Adjusting the Role of Lifestyle Factors and NMN Infusions in Aesthetic Internal Medicine

• Coordination with Other Procedures: Coordinate the timing with Botox, cosmetic dermatology treatments, and cosmetic surgery (liposuction, breast augmentation)

• Follow-up: Record "Before & After" results by combining photos, skin measurements, and health metrics

Summary

The "before and after" results of NMN IV therapy aren't the kind of thing that can be definitively judged based on a single photo.

 

These procedures differ in function from cosmetic surgery procedures—such as liposuction and breast augmentation, which directly create visible changes—and Botox, which precisely targets facial muscles, as well as cosmetic dermatology treatments that focus on the skin.

 

That is precisely why, when considering treatments in areas such as Ginza, Tokyo, it is important to articulate your goals and expectations and to adopt an approach that involves a comprehensive evaluation of your physical condition, medical data, and subjective feelings at a cosmetic internal medicine clinic.

 

Results, personal experiences, downtime, and risks vary from person to person. As a first step toward determining whether NMN IV therapy is right for you, let’s take the time to sort through your questions in a pressure-free environment and work together to create a plan that you feel comfortable with.

 

If you'd like to find out if this is right for you, please feel free to contact us.

 

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