column (e.g. in newspaper)
2026.08.12
What Is Plural? An Easy-to-Understand Explanation of Its Expected Effects, Types of Formulations, and Benefits
With deep medical insight cultivated as an internal medicine specialist, I bridge aesthetic surgery, dermatology, and internal medicine. Having spent my childhood in China, I communicate fluently in Japanese, Chinese, English, and Korean. Possessing an international perspective—evidenced by invitations to present at overseas conferences—I actively promote techniques as a Key Opinion Leader (KOL) for GOURI and REJURAN®. My specialty procedures include double eyelid surgery, skin-nurturing boosters, and body hyaluronic acid treatments. My approach leverages the holistic understanding of the body cultivated through internal medicine to guide patients toward natural, healthy beauty.
Prurial is a skin-nourishing injection that aims to improve the skin’s condition by infusing ingredients such as polynucleotides into the deeper layers of the skin. Many people probably have questions like, “How is it different from other skin-nourishing injections?” or “Can I get it around my eyes?”
At BIANCA CLINIC, we select from a range of Plural formulations based on the patient’s skin condition and the treatment area. In this article, we explain how Plural works, the different types available, the expected results, and its benefits and precautions from a doctor’s perspective.
What kind of treatment is Plurial?
Plural is a skin rejuvenation treatment that involves injecting ingredients—primarily polynucleotides—into the skin to improve skin texture by enhancing hydration and firmness.
The Role of Purial in Skin-Nurturing Injections
"Skin-nourishing injections," also known as "skin boosters," is a general term for injection treatments designed to deliver ingredients tailored to specific skin concerns deep into the skin, with the goal of improving hydration, firmness, and skin texture.
Unlike hyaluronic acid fillers, which are primarily designed to restore volume, Plural focuses on improving the overall condition of the skin. This treatment is recommended for those who wish to address multiple skin concerns—such as dryness, fine lines, redness, and loss of firmness—all at once.
What Are Polynucleotides, the Main Components?
Polynucleotide (PN) is an ingredient purified from raw materials derived from salmon and trout. When injected into the skin, it is expected to support the skin’s natural repair processes and collagen production, thereby helping to improve skin firmness and elasticity.
However, Plural is not a treatment designed to physically fill deep wrinkles or large depressions. Since it is intended to improve skin texture, other injectable or device-based treatments may be more suitable depending on the desired results.
Three types to choose from based on your body part or concern
At Bianca Clinic, we primarily offer the following three types of treatments.
Pull Real Densify
This is a formulation that combines non-crosslinked hyaluronic acid and mannitol in PN. It is used to address skin concerns such as dryness across the entire face, loss of firmness, enlarged pores, and redness.
Pullreal Silk
This formulation is designed for injection into areas with thin, delicate skin, such as around the eyes and mouth. It is an option to consider if you are concerned about fine lines or dark circles under the eyes.
Pull Real Hair Density
This product is intended for use on the scalp and hair. Its purpose and treatment plan differ from those of products designed for the face.
Bianca Clinic employs a KOL* from Plural, who shares insights on formulations and injection techniques within the clinic.
*KOL…Key Opinion Leader
What kind of results can I expect from Plural?
With Plural, you can expect it to address multiple skin concerns—such as moisture, firmness, fine lines, dullness, and redness—as well as help with thinning hair.
The main changes you can expect are as follows.
- Restore moisture to the skin
- Restores firmness and elasticity
- Makes fine lines caused by dryness less noticeable
- Even out the appearance of dull or uneven skin tone
- Aiming for skin where redness is less noticeable
- Increase Hair Volume
In addition to PN, Plural Densify contains non-crosslinked hyaluronic acid and mannitol. Non-crosslinked hyaluronic acid helps the skin retain moisture, while mannitol is an ingredient expected to help suppress inflammation and the breakdown of hyaluronic acid.
By injecting these ingredients into the dermis, this treatment comprehensively addresses issues such as fine lines and dullness caused by dryness while balancing the skin’s moisture levels and firmness. The defining feature of skin-nourishing injections is that they deliver ingredients deep into the skin, rather than simply moisturizing the skin’s surface.
In addition, Plural is sometimes used to treat skin concerns associated with redness or chronic inflammation. However, redness can have various causes, such as rosacea, dermatitis, or UV-induced irritation. If redness persists, it’s important not to rely solely on the advice of an aesthetic practitioner but to consult a doctor as well.
In addition, Plural Silk is effective for fine lines around the eyes and dark circles, while Plural Hair Densify is effective for concerns such as thinning hair and hair loss.
What are the pros and cons of Plural?
While Plural is effective for treating a variety of skin concerns, it carries risks such as pain, swelling, bruising, and allergic reactions during injection.
Benefits of Plural
- Makes it easy to address multiple skin concerns at the same time
- You can select a formulation based on the treatment site
- Aims to improve skin texture without significantly altering skin volume
One of the benefits of Plural is that it addresses a wide range of skin-related concerns, such as dryness, loss of firmness, fine lines, dullness, and redness. Since it is not a treatment that drastically alters facial contours, it is ideal for those who want to improve the overall condition of their skin.
There are various formulations available—such as Densify, Silk, and Hair Density—each designed for different purposes, so you can choose the one best suited for your needs, whether it’s for the entire face, the eye area, or the scalp. Depending on your doctor’s assessment, these treatments may be combined with other procedures, such as Potenza or Mesona J.
Disadvantages and Precautions of Plural
- You may feel pain when the needle is inserted.
- Swelling, redness, bruising, and bulging at the injection site may occur.
- Depending on the desired results, multiple sessions may be necessary.
- Treatment may not be possible in some cases due to allergies to fish or fish roe, among other reasons.
After the procedure, the injection site may temporarily swell, or redness or bruising may occur. Since the severity of these symptoms and the time it takes for them to subside vary from person to person, it’s best to avoid scheduling the procedure right before an important event.
Please refrain from undergoing this treatment if you have a fish or fish roe allergy, are pregnant or breastfeeding, or have an autoimmune disease. If you have a history of medical conditions or are currently taking any medications, please be sure to inform the doctor during your consultation.
If you have questions about your recovery after the procedure or which product is right for you,Treatments PagePlease review the information or consult with a doctor during your counseling session.
Frequently Asked Questions
Here are answers to some frequently asked questions about Plural.
Q. Please tell me about Pulrial's prices and pricing plans.
A. Prices vary depending on the product used (such as Densify, Silk, or Hair Density) and the number of treatments. Since anesthesia fees may be charged separately, please check the treatment page or price list for the most up-to-date pricing.
Q. Please tell me about the downtime associated with Plural treatment.
A. After the procedure, you may experience swelling, redness, bruising, or other reactions at the injection site. As a general rule, you may apply makeup starting the next day. The severity and duration of these symptoms vary from person to person.
Q. How long do the results of the Plural treatment last?
A. At Bianca Clinic, we generally recommend three facial treatments every two weeks, with results typically lasting between six months and one year. However, this may vary depending on skin condition, the products used, and the number of treatments.
Q. Are there any precautions I should take if this is my first time receiving a skin-nourishing injection?
A. Please inform us of any allergies, medical history, medications you are taking, and whether you are pregnant or breastfeeding before your treatment. Since Plural contains fish-derived ingredients, we cannot perform the treatment on individuals who are allergic to fish or fish roe.
Q. How do I choose a skin booster based on my skin concerns?
A. The first step is to identify the skin concerns you want to address—such as dryness, redness, enlarged pores, and fine lines—and the treatment areas. Even among skin-rejuvenating injections, the active ingredients and the specific concerns they address can vary, so be sure to have a doctor assess your skin condition before making a choice.
For those who want to improve their skin from the ground up: Consider Plural.
Plurial is a skin-rejuvenating injection that delivers ingredients—primarily polynucleotides—into the skin to address skin concerns such as dryness, loss of firmness, fine lines, dullness, and redness. You can also choose a formulation tailored to specific areas, such as the eye area or scalp.
At BIANCA CLINIC, we develop treatment plans while assessing your skin condition and treatment history. If you’re wondering whether Plural is right for you, please consult with a doctor during your consultation.
▶Please see the details of the Purial treatment.
▶Please contact us via the online reservation form.
