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2026.07.07
What Is Rejuran (Salmon Injection)? An Easy-to-Understand Explanation of Its Expected Effects, Benefits, and Drawbacks
Engaged in both aspects of cosmetic dermatology and cosmetic surgery, he is an all-rounder doctor who pursues natural and elegant beauty with "the best interest of the patient" as his first priority. He is also a board-certified cosmetic surgeon by the Japanese Society of Aesthetic Plastic Surgery (JSAS). He specializes in hyaluronic acid injections, thread lifts, and facial surgery, and is a competent KOL (Key Opinion Leader) for ARTEMISLIFT and Hydro Rejuran. He is always sensitive to the latest trends and is always exploring knowledge and techniques.
Rejuran (salmon injection) involves injecting salmon-derived PN into the skin to optimize the skin's repair environment.
For those wondering, “What kind of results can I expect?” or “Is there any pain or downtime?”, we’ll explain how it works, the different types available, and the benefits and precautions—including BIANCA CLINIC’s approach.
What is Rejuran (salmon injection)?
Rejuran is a treatment that involves injecting salmon-derived polynucleotides into the dermis to improve skin texture by harnessing the skin’s natural repair mechanisms.
Creating an Optimal Environment for Skin Repair with Polynucleotides
Rejuran is an injectable formulation whose main ingredient is polynucleotide (PN) extracted and purified from salmon-derived DNA.
By delivering PN in fine doses into the skin and optimizing the skin’s repair environment—which involves fibroblasts and other cells—this treatment helps improve skin firmness, elasticity, and texture.
Unlike hyaluronic acid, this product is not primarily designed to physically lift and reshape sunken areas. What sets Rejuran apart is that it works to improve the skin’s overall condition and aims to bring about natural changes over time.
Rejuran, which is carefully hand-mixed by a doctor to suit your skin condition, is injected in small amounts into multiple areas.
The type of product to be injected, as well as the depth and area of injection, are not fixed; it is important to determine these factors after examining the skin’s thickness, the patient’s concerns, and the treatment area.
At Bianca Clinic, our doctors perform the injections by hand, using 34-gauge fine needles and needles of varying lengths depending on the treatment area.
We also offer “Pain-Free Rejuran,” which combines anesthetics. Since pain sensitivity varies from person to person, please feel free to consult with our doctors if you have any concerns.
If you would like to learn more about the treatment method and whether it is suitable for your skin, please visit the Rejuran (Salmon Injection) treatment page.
▶Rejuran (Salmon Injection) Treatment Page
What types of Rejuran are there?
The Rejuran line includes formulations for the entire face, Rejuran i for the eye area, and Rejuran HB, which is designed to provide moisturization and help alleviate discomfort.
Rejuran and Rejuran i
Standard Rejuran is used to improve skin texture over relatively large areas, such as the entire face, forehead, neck, and décolletage.
Rejuran i is a low-viscosity formulation designed to blend easily into areas with thin skin, such as around the eyes and mouth. It is used to address concerns such as fine lines and dark circles around the eyes.
At Bianca Clinic, we don't simply choose treatments based on their brand names; instead, we conduct a thorough examination to assess skin thickness and the underlying causes of your concerns, and select the most appropriate treatment accordingly.
Rejuran HB and Salmon Boost
Rejuran HB is a formulation that combines non-crosslinked hyaluronic acid with an anesthetic agent. It addresses skin dehydration while also minimizing discomfort during injection.
In addition, Bianca Clinic offers “Salmon Boost,” a treatment that combines Rejuran HB with stem cell culture supernatant, exosomes, botulinum toxin, and other ingredients.
"Salmon Boost" is not the name of a product in the Rejuran series, but rather a combination treatment designed to improve the skin's condition using multiple ingredients.
What results can I expect from Rejuran (salmon injections)?
With Rejuran, you can expect improvements in skin firmness, elasticity, and texture, as well as in fine lines, pores, and acne scars.
The main changes you can expect from Rejuran are as follows:
- Improvements in skin firmness, elasticity, and texture
- Makes fine lines caused by dryness less noticeable
- Helps refine enlarged pores and uneven skin texture
- Helps improve acne scars and other scars
- Targets fine lines around the eyes and certain types of dark circles
By optimizing the skin's repair environment, PN can help improve skin firmness, elasticity, and hydration.
Unlike treatments that alter facial features or significantly restore volume, this procedure is considered when the goal is to gradually improve the overall condition of the skin.
However, even for the same concerns, such as “dark circles” or “enlarged pores,” there isn’t just one single cause. If the main causes are skeletal structure, fat, sagging, or pigmentation, Rejuran alone may not be sufficient to produce noticeable results.
During the consultation, we identify the cause of your skin concerns, determine whether Rejuran is appropriate for you, and recommend a treatment plan.
What are the pros and cons of Rejuran (salmon injections)?
While this treatment aims to naturally improve skin texture, it may cause pain, swelling, or bruising, and multiple sessions may be required.
Benefits of Rejuran
- Aims to improve skin texture naturally without significantly altering facial features
- There are formulations designed for use on areas with thin skin, such as around the eyes.
- You can choose a formulation based on your skin condition and the treatment area.
- It addresses multiple skin concerns, such as loss of firmness, fine lines, and enlarged pores.
Rejuran is a treatment that gradually restores the skin's firmness and elasticity, rather than instantly adding volume.
This is a good option for those who want to improve the appearance of their skin without making any drastic changes that would give away the fact they’ve had a treatment.
Disadvantages and Precautions of Rejuran
- Pain during the injection
- A small bump appears on the skin immediately after the procedure
- Redness, swelling, puffiness, and bruising may occur
- This treatment does not produce immediate, dramatic results.
- Depending on your skin condition, multiple treatments may be necessary.
Immediately after the injection, several small bumps resembling mosquito bites will appear. Most of these subside within a few hours to a day, but if bruising occurs, it may last for about a week.
Since recovery times vary from person to person, please avoid scheduling the procedure right before an important event.
While some people notice a change in their skin texture after just one session, at Bianca Clinic, we generally recommend a total of four sessions, spaced about two to three weeks apart.
Since the number of sessions required varies depending on your skin condition and treatment goals, we will develop a treatment plan tailored to your needs during your consultation.
If you have questions about your post-treatment progress or which formulation is right for you, please consult with a doctor during your consultation.
Frequently Asked Questions
Here are answers to frequently asked questions about Rejuran's ingredients, the number of treatments required, pain, downtime, and side effects.
Q. What are the main ingredients in Rejuran?
A. The main ingredient is a polynucleotide (PN) purified from salmon-derived DNA. When injected into the skin, it helps create a reparative environment involving fibroblasts and other cells, with the goal of improving firmness, elasticity, and skin texture.
Q. What is the estimated number of sessions and duration required for the Rejuran treatment?
A. At Bianca Clinic, we generally recommend a total of four sessions, spaced about 2 to 3 weeks apart, followed by maintenance treatments approximately once every six months. The number of sessions required varies depending on your skin condition, treatment goals, and the products used.
Q. Does the Rejuran treatment hurt?
A. You may feel some pain during the injection. At Bianca Clinic, in addition to topical anesthesia, we use “Pain-Free Rejuran,” which contains an anesthetic, and fine needles; however, the level of pain experienced varies from person to person.
Q. What are the side effects and precautions associated with Rejuran (salmon injections)?
A. Common side effects include redness, swelling, bruising, and swelling at the injection site. A slight swelling may last from a few hours to about one day.
Q. How long before an important event should I get the Rejuran treatment?
A. If you have important plans, please consider scheduling the procedure at least 10 days in advance to allow for recovery time. Bruising and swelling may last for 1 to 2 weeks.
Understand the features of Rejuran and choose the treatment that’s right for your skin.
When using Rejuran, it is important to choose the formulation and injection method that best suit your skin condition and goals. Start by consulting a doctor to confirm your eligibility.
Rejuran (salmon injection) is a treatment that involves injecting salmon-derived PN into the skin to improve firmness, elasticity, fine lines, and skin texture.
While the goal is to achieve a natural-looking result, there is a possibility of pain, swelling, or bruising, and multiple treatment sessions may be necessary.
At BIANCA CLINIC, we select from standard products such as Rejuran, Rejuran i, and Rejuran HB based on your skin condition, and we also employ injection techniques designed to minimize discomfort.
If you'd like to know whether Rejuran or Salmon Boost is right for your specific concerns, please feel free to come in for a consultation.
▶Please see the detailed description of the Rejuran (salmon injection) treatment.
▶Please contact us via the online reservation form.
