Ladyesse
RADIESSE®
Skin Care Using the Hyper-Diluted Method
Injection Treatments That Address a Wide Range of Concerns
- Using the hyper-dilution method to improve skin firmness and elasticity
- Leveraging the unique properties of CaHA to achieve firm, supple, and healthy skin
- From improving skin texture to facial contouring. Customized injections tailored to your goals and specific areas.
My journey into aesthetic medicine stems from a desire to help enrich and beautify lives beyond simply treating illness. My specialties include hyaluronic acid, Botox, and thread lifts. I provide treatments that enhance each individual's unique qualities and bring out an elegant, natural beauty. For concerns around the eyes that are difficult to improve with dermatology alone, I also perform surgical procedures. By integrating dermatology and surgery, I holistically balance the entire face. With three periods of overseas study, I am also able to provide consultations in English.
Using the hyperdilution method
Offering Injection Treatments
At Bianca Clinic, Radiesse treatments are performed using two methods: the “hyper-diluted method” and injection of the undiluted solution. With the hyper-diluted method, the diluted formulation is injected broadly into the appropriate layer based on the treatment area and objective. For contouring and volume restoration using the undiluted solution, the injection layer is selected based on anatomical structure and the specific objective.
Ladyesse is a filler originally developed for volume restoration and contouring, and it was typically injected in its undiluted form. However, in recent years, the “hyper-dilution” method—in which the product is diluted before use—has also been adopted overseas.
At our clinic, we determine the appropriate dilution ratio for each area and condition, and then address a variety of skin concerns through our meticulous injection design and precise injection techniques. Leveraging Radiesse’s ability to support the production of collagen and elastin, we provide customized treatments designed to blend naturally with your skin.
Downtime
DOWNTIMERecommended for people like this
RECOMMENDED.Features
CHARACTERISTICSWhat Is Ladyesse?
It is believed that the mechanism of action of Ladyesse involves CaHA stimulating fibroblasts to support the production of components that make up the extracellular matrix (ECM), such as collagen and elastin. Another key feature is that, following treatment, changes in skin texture can be expected over time due to CaHA’s effect on collagen and elastin production. The extent and duration of these changes vary depending on the injection site, injection method, dosage, and individual differences.
*Biostimulator… A general term for formulations and treatments that support the production of collagen and other substances and help improve skin firmness and elasticity
*ECM…A general term for components—such as collagen and elastin—that support the structure of tissues by surrounding cells.
Achieve Firm, Supple Skin with the Hyper-Dilute Method
The Hyper-Dilute Method is suitable not only for the face but also for body treatments, such as horizontal wrinkles on the neck and décolletage—areas where signs of aging are particularly noticeable—as well as the backs of the hands. It is characterized by its ability to promote the production of collagen and elastin within the skin, helping you achieve a natural, youthful appearance.
Injecting the undiluted solution can also add volume and enhance facial contours
For example,
・Fills deep wrinkles such as nasolabial folds and marionette lines
・Sculpt the jawline to achieve the ideal "E-line"
It is used in cases such as these.
Because Ladyesse has moderate elasticity, it possesses physical properties suitable for contouring and supports the production of collagen and elastin, aiming to improve skin firmness and elasticity. In addition to providing immediate volume correction upon injection, Ladyesse is also expected to stimulate collagen production due to the properties of CaHA.
Benefits
MERITCapable of addressing everything from skin texture improvement to facial contouring
By adjusting the dilution ratio, it can be used for a wide range of purposes, from improving skin texture by supporting the production of collagen and elastin to restoring volume and contouring the face.
An approach focused on the ECM, which forms the foundation of the skin
The main ingredient, CaHA, interacts with fibroblasts to regulate the ECM—the foundation that physically supports the skin’s firmness and elasticity—and nourishes the skin itself.
Injection designs can be tailored to specific body areas
In addition to the face, it can be used on other parts of the body, such as the neck, décolletage, and the backs of the hands, allowing for a customized injection design tailored to each area.
Recommended Features
KEY FEATURESBringing about change through injection into the appropriate layers based on anatomy
At Bianca Clinic, we carefully evaluate the overall balance of the face from an anatomical perspective and propose an injection plan tailored to each individual patient. The key to a successful Ladyesse treatment is the technique of accurately injecting the product into the appropriate layer while taking into account the location of blood vessels and nerves.
With the hyperdilution method, the solution is injected into the superficial layers of the skin, whereas with the standard method using the undiluted solution, it is injected into the deeper layers. A physician with a thorough understanding of anatomy will determine the appropriate layer based on the treatment goal and perform the procedure with care.
CaHA's Approach to Skin Firmness and Elasticity
CaHA, the main ingredient in Ladyesse, acts as a biostimulator to help promote firm, elastic skin. By targeting fibroblasts, CaHA supports the production of collagen and elastin, which is expected to help rebuild the skin from the foundation up.
As a result, it is characterized by its ability to gradually improve skin thickness and texture over time, leading to a healthy and youthful-looking complexion. As a treatment that promotes skin firmness and elasticity, Ladyesse is considered one of the most suitable procedures for long-term anti-aging care.
It can be injected into a wide range of treatment areas, including the face and body
Ladyesse is a highly versatile formulation that can be used on a wide range of areas—from the face to the body—by adjusting the dilution ratio. It can be applied not only to areas of concern on the face but also to body areas where signs of aging are most noticeable, such as the neck, décolletage, and the backs of the hands.
At Bianca Clinic, we offer customized treatments tailored to your specific concerns for each area of the body. If you have any areas you’re curious about—such as, “I wonder if I can get a Ladyesse treatment here, too?”—please feel free to ask during your consultation or examination.
Treatment area
TREATMENT AREAForehead, temples, cheeks, nasolabial folds, marionette lines, chin, jawline, neck, décolletage, backs of the hands, etc.
Treatment Process
TREATMENT FLOWPhysician's examination and counseling
A doctor will listen carefully to your concerns and determine whether you are a suitable candidate for Ladyesse. We will explain the details of the procedure, so please feel free to ask any questions you may have.
Makeup removal at the injection site
If you are having Ladyesse injected into your face, please remove your makeup first.
treatment
Depending on the injection site and purpose, we use either a needle or a microcannula with a rounded tip. The procedure takes about 30 minutes.
Schedule of Charges
PRICE LIST| Treatment Details | Standard rate |
|---|---|
| Ladyesse | 115,500 yen |
*A separate charge of 2,600 yen applies for the cannula.
Lifestyle Beautyis
proposed.
Our goal is to move you beyond satisfaction.
Responding to the desire for greater beauty and health,
What can we do for the well-being of our patients?
Providing total beauty to make your life shine,
That is our policy.
Go to BIANCA and you'll find a smile.
That's the kind of place we're aiming for.
Recommended products for this concern
FOR YOUR CONCERN
Ladyesse FAQs
Q&AIs there any pain or downtime during the procedure?
To minimize discomfort, we use either a needle or a microcannula with a rounded tip, depending on the injection site and the treatment’s purpose. If you’re concerned about pain, we can use anesthetic—please let us know. During the recovery period, you may experience mild swelling or redness, and in rare cases, bruising; however, these can be easily covered with makeup.
What is the hyperdilution method?
This method involves diluting Ladyesse with saline solution or a similar fluid and injecting it. Rather than simply adding volume, the primary goal is to improve skin quality by leveraging CaHA’s ability to stimulate collagen and elastin production. Treatments using diluted or highly diluted CaHA have also been reported overseas for use on the face, neck, and décolletage.
Are injections into areas such as the jaw and bridge of the nose also performed using the hyperdilution method?
When performing contouring procedures—such as shaping the jawline or the bridge of the nose—or filling wrinkles and depressions, such as nasolabial folds and the cheeks, it is standard practice to inject the undiluted solution. If the goal is to improve skin texture, the hyperdilution method is selected.
Can Ladyesse be injected into the lips or under the eyes?
No. Given the risk of lumps or unevenness, our clinic does not perform injections in areas with thin, delicate skin, such as the lips or under the eyes.
Can it be injected into the body as well as the face?
Yes, that is possible. At our clinic, we administer Radiesse to areas such as the neck, décolletage, and the backs of the hands. Please ask your doctor for more details.
What is the difference between hyaluronic acid injections and Radiesse?
Hyaluronic acid injections are fillers with a soft texture used for volume restoration and facial contouring. Radiesse, on the other hand, has a thick, slightly firmer texture and, in addition to volume restoration and facial contouring, is designed to promote firmer skin from within.
Is there a risk of developing a lump after the procedure?
To minimize the risk of lumps forming, it is important to determine the appropriate layer and volume of filler. At our clinic, we carefully assess the injection site, layer, and volume based on anatomical principles, and perform the procedure meticulously while taking into account risks such as lumps.
Is it possible for the injected area to turn into bone?
CaHA, the main ingredient in Ladyesse, is a component found in bone; however, this procedure is not intended to transform the injected product itself into normal bone. At our clinic, the procedure is performed by physicians with a thorough understanding of anatomy, who carry it out carefully and with the utmost attention to detail.
Can it show up on X-ray or CT scans?
Yes. CaHA, the main ingredient in Ladyesse, may appear white on X-ray or CT scans. Please inform your doctor or dentist of this in advance of any imaging tests.
Related Articles
BLOG
[Treatment Details] Radiesse® *This treatment is not covered by insurance.
[Estimated Treatment Duration and Number of Sessions] Per session *May vary depending on individual circumstances. Regular injections may be necessary to maintain the results of the treatment.
[Risks, Side Effects, etc.] Redness, swelling, bruising, pain, tenderness, edema, infection, allergic reactions, induration, nodules, asymmetry, etc. In rare cases, serious complications such as vascular embolism, associated skin damage or necrosis, and visual impairment may occur.
【Important Notes Regarding Unapproved Medicines】
・RADIESSE®, which is used in this procedure, is an unapproved drug in Japan under the Act on Pharmaceutical and Medical Devices.
・Medicines used in treatments are imported through personal import procedures under the supervision of a physician. For details, please refer to the Ministry of Health, Labour and Welfare's "Information on Medicines Requiring Caution for Personal Import."
https://www.yakubutsu.mhlw.go.jp/individualimport/purchase/index.html
・There are no approved pharmaceuticals or other products in Japan that have the same ingredients or performance characteristics as RADIESSE®.
・Information regarding safety and other matters in other countries
"RADIESSE®" has been approved by the U.S. FDA (Food and Drug Administration) for the following purposes:
—Correction of moderate to severe facial wrinkles and furrows (such as nasolabial folds)
—Improving Volume Loss on the Back of the Hand (Hand Augmentation)
- Wrinkle correction on the décolletage (chest area) in patients aged 22 and older (when using a 1:2 dilution protocol with saline solution)
・Serious risks or side effects may not yet be known.
・In the unlikely event of serious side effects, you may not be eligible for the national compensation system (Pharmaceutical Side Effects Victim Relief System).
