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2026.08.20
What Are the Effects of Lituo? A Doctor Explains When You’ll Start to Feel the Effects, How Often to Take It, and How Long They Last
Engaged in both aspects of cosmetic dermatology and cosmetic surgery, he is an all-rounder doctor who pursues natural and elegant beauty with "the best interest of the patient" as his first priority. He is also a board-certified cosmetic surgeon by the Japanese Society of Aesthetic Plastic Surgery (JSAS). He specializes in hyaluronic acid injections, thread lifts, and facial surgery, and is a competent KOL (Key Opinion Leader) for ARTEMISLIFT and Hydro Rejuran. He is always sensitive to the latest trends and is always exploring knowledge and techniques.
Rituo is a collagen skin booster that directly replenishes the skin with human-derived ECM components. It is expected to be effective against a variety of skin concerns, including firmness, elasticity, hydration, fine lines, and pores.
Some of you may be wondering, “What does Lituo do?” “When will I start to notice a difference?” and “How is it different from other collagen products?”
Rituo (Re2O·Bunaju) is an injectable treatment composed primarily of human acellular dermal matrix (hADM) that directly replenishes the components that form the skin’s foundation.
At BIANCA CLINIC, we offer not only Rituo but also several other collagen products. Therefore, rather than focusing on a specific product, we prioritize planning treatment after assessing your skin concerns, the treatment area, and the specific results you hope to achieve.
In this article, we’ll explain the benefits you can expect from Rituo, its features, when you’ll start to notice results, and the frequency and duration of use.
What kind of effects can be expected from Rituo?
Rituo is an injectable treatment that restores skin firmness, elasticity, and hydration, addressing a variety of skin concerns such as fine lines, pores, and skin texture.
Restores skin that shows signs of loss of firmness and elasticity
"My skin feels thinner than it used to" and "It's losing its firmness" are among the concerns I often hear from patients during consultations.
Rituo aims to improve skin firmness and elasticity from the foundation up by directly replenishing the components of the ECM (extracellular matrix) that support the skin.
Its defining feature is that it is not intended to add significant volume, but rather to naturally refine the skin’s natural texture.
Targets fine lines around the eyes, as well as pores and skin texture
In addition to being used on fine lines around the eyes, on the forehead, between the eyebrows, and on nasolabial folds, Rituo is also used on skin with visible pores and uneven texture.
Rather than focusing on just one concern, we tailor your treatment plan by assessing the overall condition of your skin, including firmness, texture, and hydration.
Aiming for Hydrated Skin
By replenishing ECM components, Lituo is expected to help restore the skin from the foundation up and enhance its moisture levels.
However, even when using the same Rituo treatment, how you perceive the results may vary depending on the changes you’re seeking and your current skin condition. When choosing a treatment, it’s important not only to have a general desire to “make your skin look better,” but also to identify which specific concerns you want to address first.
See the Effects of Rituo in Case Photos
The following are case studies showing the use of Rituo for various skin types and under-eye wrinkles.
Treatment Duration and Number of Sessions: Top: Before Treatment; Bottom: 8 Weeks After Treatment
This case is a reference case provided by the supplier of the formulation.
Side Effects and Risks: Swelling, redness, puffiness, small nodules, etc.
Cost: Lituo Re2O (Bunaju): 110,000 yen; topical anesthetic fee: 3,630 yen
Treatment Period and Number of Sessions: Left: Before Surgery; Right: 1.5 Months After Surgery
*This graph shows the skin condition ranking (percentile) compared to peers of the same age. Yellow represents the pre-treatment assessment, and purple represents the assessment 1.5 months after treatment. An increase in the score is evident after treatment, confirming that the condition of wrinkles has improved to a better level compared to peers of the same age.
Side Effects and Risks: Swelling, redness, puffiness, small nodules, etc.
Cost: 115,500 yen per session; topical anesthesia fee: 3,630 yen
*The photos shown are for illustrative purposes only. Results and progress may vary from person to person.
What Kind of Collagen Supplement Is Rituo? An Explanation of Its Key Features That Lead to Results
Rituo is a skin booster that uses hADM derived from human dermis. It is characterized by its ability to directly replenish the skin with ECM components, including collagen.
Directly replenishes the ECM components that form the foundation of the skin
ECM is a foundation-like structure that surrounds skin cells and supports the structure of the tissue.
Some conventional skin boosters are formulated to stimulate the skin and encourage the body's own collagen production. In contrast, Lituo is a treatment based on the concept of directly replenishing the ECM components—such as collagen and elastin—that make up the skin.
In addition, Lituo contains Type I and Type III collagen, which help support the skin's structural integrity.
BIANCA At the CLINIC, we evaluate several collagen products
Rituo isn't the only treatment that uses collagen injections.
At Bianca Clinic, in addition to Rituo,Baby Dermbaby collagen-based products such as, andCerdiem (Skin Plus)We carry these items.
Babyderm is a formulation whose main ingredients are human placenta-derived Type I, III, and V collagen. It is used as a skin rejuvenation treatment aimed at achieving a natural appearance, targeting fine lines around the eyes, dark circles, and nasolabial folds, among other concerns.
On the other hand, Seldiem (Skin Plus) is a skin booster based on human-derived ECM. It is designed to address a variety of skin concerns, including firmness, elasticity, fine lines, dryness, and enlarged pores.
Don't ask, "Which product is best?"—choose based on your skin concerns.
Although we use the general term “collagen preparations,” the tissues from which they are derived, the ingredients they contain, and their intended purposes are not all the same.
During the consultation, we’ll discuss your specific preferences, such as “I’d like to focus on smoothing out fine lines around the eyes,” “I’m concerned about my overall skin condition, including pores and firmness,” or “I’d like to achieve a natural-looking result.”
At Bianca Clinic, rather than applying a single formulation to everyone, our doctors assess each patient’s skin condition and the treatment area, and determine the most appropriate injection treatment based on the desired results.
For information on the basic features, advantages, and disadvantages of Lituo, see “What Is Lituo Re2O (Bunaju)? An Easy-to-Understand Explanation of Its Expected Effects, Benefits, and Drawbacks"Please also see..."
When will I start to feel the effects of Rituo?
Rituo is not a treatment designed to produce immediate, dramatic results; rather, it is a procedure that allows you to gradually notice changes in your skin's texture over the course of several weeks.
Estimated Timeframe for Noticing Results
Rituo is not a treatment primarily designed to produce significant changes in volume immediately after injection, as is the case with hyaluronic acid injections.
While some people feel their skin become firmer immediately after the treatment, most notice a gradual improvement in their skin texture over the course of several weeks.
The timing and extent of changes vary depending on your skin condition and the treatment area. Since there’s no guarantee that results will appear by a certain number of days, it’s important to monitor your skin’s condition over time.
When assessing the results, check your “entire face.”
When observing changes in Rituo, we examine the skin as a whole—including firmness, texture, and pores—rather than focusing on just a single wrinkle.
If you wish, we can also use VISIA to objectively assess your skin condition while discussing your treatment plan.
How many times should I get Rituo? How long do the effects last?
Rituo recommends starting with about three treatments, once a month. The effects typically last about six months to a year, though this varies from person to person.
Guidelines for the Number of Treatments and Intervals
You may notice a change in your skin texture after just one Rituo treatment, but we recommend starting with about three treatments, spaced one month apart.
After that, depending on the condition of your skin, you may want to have maintenance treatments about once every six months.
Since the number of sessions required varies depending on your skin condition and the desired results, it is important to develop a treatment plan based on how your skin responds over time, rather than simply deciding on a fixed number of sessions and continuing with the treatments.
Duration of Effect
The effects of Rituo vary from person to person, but generally last about six months to one year.
Since your skin changes over time due to aging and environmental factors, a single treatment won’t guarantee that your skin will remain in the same condition indefinitely. Be sure to check your skin’s condition regularly and consider follow-up treatments as needed.
Frequently Asked Questions About the Effects of Lituo
We’ll answer common questions you might have when choosing a treatment, such as the differences between Lituo and other collagen products, as well as treatments for the eye area and pores.
Q. Are Rituo and Babyderm the same collagen products?
A. Although both are injectable treatments that use human-derived collagen, they differ in their source and composition. Rituo is derived from human dermis (hADM), while Babyderm is primarily composed of types I, III, and V collagen derived from the human placenta.
Q. How do I choose between Lituo and Skin Plus?
A. While both are skin boosters that focus on ECM, their formulations and characteristics differ. After assessing your skin concerns, the treatment area, and your desired results during a consultation, we will determine the most suitable formulation for you.
Q. Can I use Rituo on fine lines under my eyes?
A. Fine lines around the eyes are one of the treatment areas for Lituo. However, since concerns around the eyes can stem from multiple causes—such as dark circles and hollows, in addition to wrinkles—we will assess your condition during a consultation to determine the appropriate treatment method.
Q. Can Rituo be expected to be effective on pores?
A. Lituo is sometimes used to improve skin texture, including the appearance of pores. However, since the causes of visible pores vary depending on skin condition, other treatments may be more appropriate in some cases.
Q. Are all collagen supplements the same?
A. They are not the same. Collagen products differ in terms of their source, ingredients, and intended therapeutic purposes. It is important not to choose a product simply because you “want collagen,” but rather to discuss with your doctor the specific concerns you wish to address and the treatment area before making a decision.
If you want to know about the effects of Rituo, consult your doctor when choosing a formulation.
Rituo is an injectable treatment designed to replenish the skin with human-derived ECM components, aiming to address a range of skin concerns, including firmness, elasticity, fine lines, pores, skin texture, and hydration.
On the other hand, there are several collagen products to choose from, such as Babyderm and Celdium (Skin Plus), each with different purposes and characteristics.
The key is not to make “getting a Lituo treatment” the goal in itself, but to clearly identify which skin concerns you want to address.
At BIANCA CLINIC, our doctors will discuss treatment options with you while assessing your skin condition, the treatment area, and your desired results. If you’re unsure whether Lituo is right for you or if another collagen product might be a better fit, please feel free to discuss your concerns during your consultation.
▶Detailed Information on Rituo Re2O (Bunaju)
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